10 Years of Neuropharmacology


Book Description

I am delighted to write a preface for this Celebratory eBook published in the Specialty Section Neuropharmacology, within the journal Frontiers in Pharmacology. The eBook delivers a compendium of high impact papers published previously in the journal over the last ten years; at the time of writing this collection of 20 papers has been viewed 700k times with over 75k downloads. Clearly this Section is delivering a useful resource to the scientific and medical research community! The scope of the Specialty Section Neuropharmacology is deliberately broad. We encourage submission of high quality and impactful papers in the field of neuropharmacology along the full length of the translational escalator; from cellular and molecular investigations to clinical trials. I believe this is a real strength of the Section and helps attract a diverse readership that builds the stakeholder network to promote further engagement of the Section with the research community. I have no doubt that this has contributed to the growth of the Section with submissions and accepted papers displaying 10-year (2009-2019) compound annual growth rates (CAGRs) of 58% and 78%, respectively. Vitaly, high quality, scientific rigour and impact are fundamental to a paper being accepted and this inevitably leads to a relatively high level of rejection, but the transparency of the review process means a fair decision is reached. Essential for the handling and considered review of submitted papers, the Specialty Section Neuropharmacology has a dynamic cohort of Associate Editors that have been selected carefully (81 at the time of writing) that represent the full spectrum of neuropharmacology as well as being widespread geographically around the globe. The Associate Editors are supported by nearly 500 Review Editors that ensures informed review – indeed the relatively open and interactive review process often adds considerably to the accepted version of the paper. As we celebrate the success of Frontiers in Pharmacology and the Specialty Section Neuropharmacology with this eBook, we must also recognise and be thankful for the hard work and dedication of those in the Editorial Office; their enthusiasm and willingness to help is outstanding and they form an integral component of the overall team that delivers the success. I look forward to further success for the Specialty Section Neuropharmacology. Happy reading! Professor Nicholas M. Barnes, FBPhS Specialty Chief Editor, Neuropharmacology




Caffeine for the Sustainment of Mental Task Performance


Book Description

This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.




Concepts and Principles of Pharmacology


Book Description

Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.




Essential Neuropharmacology


Book Description

Essential Neuropharmacology: The Prescriber's Guide reviews the full range of medications used by neurologists in clinical practice. Expert knowledge is given about the best use of medications in patient care. Each drug listing contains the full range of indications, their advantages and disadvantages, and tips for dosing and avoiding adverse effects. Evidence is taken from recent clinical trials, which helps the reader relate the drug descriptions to everyday clinical practice. Where appropriate, off-label uses are also described. The detailed descriptions of each medication enable the user to make quick and informed decisions with the confidence they need to serve the clinical needs of their patients effectively. The new edition is fully updated throughout. Major new additions include neuro-oncology drugs, new multiple sclerosis agents, sleep medications and new formulations. This book is an essential, user-friendly reference suitable for neurologists at all stages of their careers.







Neuroscience for Psychologists


Book Description

This textbook is intended to give an introduction to neuroscience for students and researchers with no biomedical background. Primarily written for psychologists, this volume is a digest giving a rapid but solid overview for people who want to inform themselves about the core fields and core concepts in neuroscience but don’t need so many anatomical or biochemical details given in “classical” textbooks for future doctors or biologists. It does not require any previous knowledge in basic science, such as physics or chemistry. On the other hand, it contains chapters that do go beyond the issues dealt with in most neuroscience textbooks: One chapter about mathematical modelling in neuroscience and another about “tools of neuroscience” explaining important methods. The book is divided in two parts. The first part presents core concepts in neuroscience: Electrical Signals in the Nervous System Basics of Neuropharmacology Neurotransmitters The second part presents an overview of the neuroscience fields of special interest for psychology: Clinical Neuropharmacology Inputs, Outputs and Multisensory Processing Neural Plasticity in Humans Mathematical Modeling in Neuroscience Subjective Experience and its Neural Basis The last chapter, “Tools of Neuroscience” presents important methodogical approaches in neuroscience with a special focus on brain imaging. Neuroscience for Psychologists aims to fill a gap in the teaching literature by providing an introductory text for psychology students that can also be used in other social sciences courses, as well as a complement in courses of neurophysiology, neuropharmacology or similar in careers outside as well as inside biological or medical fields. Students of data sciences, chemistry and physics as well as engineering interested in neuroscience will also profit from the text.




Neuropsychopharmacology


Book Description

Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of all neuropsychiatric disorders. Nine sections focus on specific groups of disorders, covering clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC




Local-spinal Therapy of Spasticity


Book Description

Historical photograph of spinal anaesthesia In 1884 the American neurologist J. L. eases. His discovery, however, marks the Corning, by blocking the neural con onset of the era of regional anaesthesia. It took almost one hundred years until his duction to the hind extremities of a dog by injecting cocaine-solution into the lumbar original idea of "local medication of the vertebral interspace, was the first to per cord" was again reconsidered due to two form spinal (or epidural?) anaesthesia [1]. reasons: At that time, he was unaware of the local I. The discovery of different drug receptors anaesthetic properties of cocaine (dis in the spinal cord made it possible, by in covered in the same year by C. Koller, who trathecal injection (or epidural appli cation, if the drug penetrates the dura), applied cocaine to the eye of one of his pa tients [3]) and did not intend to introduce to alter nociceptive or motor transmis an anaesthetic procedure. Corning's pri sion within the spinal cord. mary aim was the application of drugs in 2. Implantable devices for long-term appli proximity of the central nervous system, i. e. cation of drugs to specific sites of the spinal cord, in order to treat or even heal body, including the spinal spaces, were developed during the 1970's.




Neuroscience at a Glance


Book Description

Neuroscience at a Glance is designed to provide medical students and other allied health students who require a concise guide to neuroscience, with a quick review of a traditionally complex field. The authors successfully integrate anatomy, biochemistry, physiology and pharmacology to provide a review of the structure and function of the nervous system. Although not a clinical neurology text, the second edition includes four new chapters on Examination of the Nervous System, Investigation of the Nervous System, Clinical Disorders of the Sensory Pathways and Clinical Disorders of the Motor Pathways. The introduction of these new chapters provides excellent clinical relevence for readers while the book continues to provide accessible up-to-date explanations of neuroscience. All in all, the second edition of Neuroscience at a Glance provides students with an invaluable review of this complex subject. "Neuroscience at a Glance gives you just the right amount of information presented in a student-friendly format...There is also a free online companion to the book at www.medicalneuroscience.com containing glossaries and relevant further reading signposts which I found useful. In my opinion, it gives the student everything needed to learn about and understand the working of the brain and spinal cord without bogging you down by over-complicating things." "Neuroscience. would have been much easier to understand if I had had this book" Barts and the London Chronicle




The Pharmacology of Synapses


Book Description

The Pharmacology of Synapses details the advancements in the understanding of synaptic pharmacology. The book examines the development in various areas of synaptic pharmacology research. The text first covers the basic concepts of synaptic pharmacology, and then proceeds to tackling the metabolism of acetylcholine. Next, the selection deals with monoamine in the central nervous system, and neuromuscular transmission in vertebrates. The text also discusses the pharmacology of autonomic ganglia. Chapters 7 and 8 detail the pharmacological studies on neurons in the brain and spinal cord. The ninth chapter deals with the neuromuscular transmission in invertebrates, while the 10th chapter deals with drugs, transmission, and molluskan neurons. The book will be of great use to researchers and practitioners of pharmacology, neurology, biological psychology, and psychiatry.