Author : Byron J.T. Morgan
Publisher : CRC Press
Page : 542 pages
File Size : 13,73 MB
Release : 1992-09-01
Category : Mathematics
ISBN : 9780412317507
This book takes the standard methods as the starting point, and then describes a wide range of relatively new approaches and procedures designed to deal with more complicated data and experiments - including much recent research in the area. Throughout mention is given to the computing requirements - facilities available in large computing packages like BMDP, SAS and SPSS are also described.
Author : John W. Green
Publisher : John Wiley & Sons
Page : 416 pages
File Size : 41,78 MB
Release : 2018-08-14
Category : Science
ISBN : 1119088348
A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book's topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending OECD and USEPA ecotoxicity guidelines. This important guide: Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicals Contains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicity Includes an introduction to toxicity experiments and statistical analysis basics Includes programs in R and excel Covers the analysis of continuous and Quantal data, analysis of data as well as Regulatory Issues Presents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.
Author : Wayne B. Nelson
Publisher : John Wiley & Sons
Page : 656 pages
File Size : 43,60 MB
Release : 2005-02-25
Category : Technology & Engineering
ISBN : 0471725226
WILEY-INTERSCIENCE PAPERBACK SERIES The Wiley-Interscience Paperback Series consists of selected books that have been made more accessible to consumers in an effort to increase global appeal and general circulation. With these new unabridged softcover volumes, Wiley hopes to extend the lives of these works by making them available to future generations of statisticians, mathematicians, and scientists. "Many examples drawn from the author’s experience of engineering applications are used to illustrate the theoretical results, which are presented in a cookbook fashion...it provides an excellent practical guide to the analysis of product-life data." –T.M.M. Farley Special Programme of Research in Human Reproduction World Health Organization Geneva, Switzerland Review in Biometrics, September 1983 Now a classic, Applied Life Data Analysis has been widely used by thousands of engineers and industrial statisticians to obtain information from life data on consumer, industrial, and military products. Organized to serve practitioners, this book starts with basic models and simple informative probability plots of life data. Then it progresses through advanced analytical methods, including maximum likelihood fitting of advanced models to life data. All data analysis methods are illustrated with numerous clients' applications from the author's consulting experience.
Author : Jacqueline L. Robertson
Publisher :
Page : 20 pages
File Size : 36,22 MB
Release : 1980
Category : Computer programs
ISBN :
Describes the computer program POLO from experimental design, through data input, to program output.
Author : Ronald J. Tallarida
Publisher : CRC Press
Page : 268 pages
File Size : 25,13 MB
Release : 2000-07-21
Category : Mathematics
ISBN : 1420036106
Not since this author's bestselling Manual of Pharmacologic Calculation has there been an available reference for drug data analysis. Incorporating the most relevant parts of that work, Drug Synergism and Dose-Effect Data Analysis focuses on drug combinations and all the quantitative analyses needed to analyze drug combination dose-effect data and to design experiments with two or more compounds. The book contains the statistical methods, the theory, and the computation algorithms needed to analyze single and combination drug data. Numerous examples accompany a presentation that illustrates the calculations and experimental design considerations for modern drug analysis.
Author : Byron J. T. Morgan
Publisher : Springer
Page : 511 pages
File Size : 43,49 MB
Release : 1990
Category : Science
ISBN : 9781489945402
Author : Wayne B. Nelson
Publisher : SIAM
Page : 157 pages
File Size : 23,69 MB
Release : 2003-01-01
Category : Technology & Engineering
ISBN : 0898715229
Survival data consist of a single event for each population unit, namely, end of life, which is modeled with a life distribution. However, many applications involve repeated-events data, where a unit may accumulate numerous events over time. This applied book provides practitioners with basic nonparametric methods for such data.
Author : Christian Ritz
Publisher : CRC Press
Page : 310 pages
File Size : 42,70 MB
Release : 2019-07-19
Category : Mathematics
ISBN : 135198103X
Nowadays the term dose-response is used in many different contexts and many different scientific disciplines including agriculture, biochemistry, chemistry, environmental sciences, genetics, pharmacology, plant sciences, toxicology, and zoology. In the 1940 and 1950s, dose-response analysis was intimately linked to evaluation of toxicity in terms of binary responses, such as immobility and mortality, with a limited number of doses of a toxic compound being compared to a control group (dose 0). Later, dose-response analysis has been extended to other types of data and to more complex experimental designs. Moreover, estimation of model parameters has undergone a dramatic change, from struggling with cumbersome manual operations and transformations with pen and paper to rapid calculations on any laptop. Advances in statistical software have fueled this development. Key Features: Provides a practical and comprehensive overview of dose-response analysis. Includes numerous real data examples to illustrate the methodology. R code is integrated into the text to give guidance on applying the methods. Written with minimal mathematics to be suitable for practitioners. Includes code and datasets on the book’s GitHub: https://github.com/DoseResponse. This book focuses on estimation and interpretation of entirely parametric nonlinear dose-response models using the powerful statistical environment R. Specifically, this book introduces dose-response analysis of continuous, binomial, count, multinomial, and event-time dose-response data. The statistical models used are partly special cases, partly extensions of nonlinear regression models, generalized linear and nonlinear regression models, and nonlinear mixed-effects models (for hierarchical dose-response data). Both simple and complex dose-response experiments will be analyzed.
Author : Maura E. Stokes
Publisher : SAS Institute
Page : 589 pages
File Size : 25,35 MB
Release : 2012-07-31
Category : Computers
ISBN : 1612900909
Statisticians and researchers will find Categorical Data Analysis Using SAS, Third Edition, by Maura Stokes, Charles Davis, and Gary Koch, to be a useful discussion of categorical data analysis techniques as well as an invaluable aid in applying these methods with SAS. Practical examples from a broad range of applications illustrate the use of the FREQ, LOGISTIC, GENMOD, NPAR1WAY, and CATMOD procedures in a variety of analyses. Topics discussed include assessing association in contingency tables and sets of tables, logistic regression and conditional logistic regression, weighted least squares modeling, repeated measurements analyses, loglinear models, generalized estimating equations, and bioassay analysis. The third edition updates the use of SAS/STAT software to SAS/STAT 12.1 and incorporates ODS Graphics. Many additional SAS statements and options are employed, and graphs such as effect plots, odds ratio plots, regression diagnostic plots, and agreement plots are discussed. The material has also been revised and reorganized to reflect the evolution of categorical data analysis strategies. Additional techniques include such topics as exact Poisson regression, partial proportional odds models, Newcombe confidence intervals, incidence density ratios, and so on. This book is part of the SAS Press program.
Author :
Publisher : John Wiley & Sons
Page : 2163 pages
File Size : 43,27 MB
Release : 2008-09-02
Category : Mathematics
ISBN : 0470035498
Leading the way in this field, the Encyclopedia of Quantitative Risk Analysis and Assessment is the first publication to offer a modern, comprehensive and in-depth resource to the huge variety of disciplines involved. A truly international work, its coverage ranges across risk issues pertinent to life scientists, engineers, policy makers, healthcare professionals, the finance industry, the military and practising statisticians. Drawing on the expertise of world-renowned authors and editors in this field this title provides up-to-date material on drug safety, investment theory, public policy applications, transportation safety, public perception of risk, epidemiological risk, national defence and security, critical infrastructure, and program management. This major publication is easily accessible for all those involved in the field of risk assessment and analysis. For ease-of-use it is available in print and online.
