Fitting Models to Biological Data Using Linear and Nonlinear Regression


Book Description

Most biologists use nonlinear regression more than any other statistical technique, but there are very few places to learn about curve-fitting. This book, by the author of the very successful Intuitive Biostatistics, addresses this relatively focused need of an extraordinarily broad range of scientists.




Linear and Nonlinear Models


Book Description

This monograph contains a thorough treatment of methods for solving over- and underdetermined systems of equations, e.g. the minimum norm solution method with respect to weighted norms. The considered equations can be nonlinear or linear, and deterministic models as well as probabilistic ones are considered. An extensive appendix provides all necessary prerequisites like matrix algebra, matrix analysis and Lagrange multipliers, and a long list of references is also included.




Applied Statistics in Agricultural, Biological, and Environmental Sciences


Book Description

Better experimental design and statistical analysis make for more robust science. A thorough understanding of modern statistical methods can mean the difference between discovering and missing crucial results and conclusions in your research, and can shape the course of your entire research career. With Applied Statistics, Barry Glaz and Kathleen M. Yeater have worked with a team of expert authors to create a comprehensive text for graduate students and practicing scientists in the agricultural, biological, and environmental sciences. The contributors cover fundamental concepts and methodologies of experimental design and analysis, and also delve into advanced statistical topics, all explored by analyzing real agronomic data with practical and creative approaches using available software tools. IN PRESS! This book is being published according to the “Just Published” model, with more chapters to be published online as they are completed.




Applications of Linear and Nonlinear Models


Book Description

Here we present a nearly complete treatment of the Grand Universe of linear and weakly nonlinear regression models within the first 8 chapters. Our point of view is both an algebraic view as well as a stochastic one. For example, there is an equivalent lemma between a best, linear uniformly unbiased estimation (BLUUE) in a Gauss-Markov model and a least squares solution (LESS) in a system of linear equations. While BLUUE is a stochastic regression model, LESS is an algebraic solution. In the first six chapters we concentrate on underdetermined and overdeterimined linear systems as well as systems with a datum defect. We review estimators/algebraic solutions of type MINOLESS, BLIMBE, BLUMBE, BLUUE, BIQUE, BLE, BIQUE and Total Least Squares. The highlight is the simultaneous determination of the first moment and the second central moment of a probability distribution in an inhomogeneous multilinear estimation by the so called E-D correspondence as well as its Bayes design. In addition, we discuss continuous networks versus discrete networks, use of Grassmann-Pluecker coordinates, criterion matrices of type Taylor-Karman as well as FUZZY sets. Chapter seven is a speciality in the treatment of an overdetermined system of nonlinear equations on curved manifolds. The von Mises-Fisher distribution is characteristic for circular or (hyper) spherical data. Our last chapter eight is devoted to probabilistic regression, the special Gauss-Markov model with random effects leading to estimators of type BLIP and VIP including Bayesian estimation. A great part of the work is presented in four Appendices. Appendix A is a treatment, of tensor algebra, namely linear algebra, matrix algebra and multilinear algebra. Appendix B is devoted to sampling distributions and their use in terms of confidence intervals and confidence regions. Appendix C reviews the elementary notions of statistics, namely random events and stochastic processes. Appendix D introduces the basics of Groebner basis algebra, its careful definition, the Buchberger Algorithm, especially the C. F. Gauss combinatorial algorithm.




Nonlinear Regression Analysis and Its Applications


Book Description

Provides a presentation of the theoretical, practical, and computational aspects of nonlinear regression. There is background material on linear regression, including a geometrical development for linear and nonlinear least squares.




Sampled-Data Models for Linear and Nonlinear Systems


Book Description

Sampled-data Models for Linear and Nonlinear Systems provides a fresh new look at a subject with which many researchers may think themselves familiar. Rather than emphasising the differences between sampled-data and continuous-time systems, the authors proceed from the premise that, with modern sampling rates being as high as they are, it is becoming more appropriate to emphasise connections and similarities. The text is driven by three motives: · the ubiquity of computers in modern control and signal-processing equipment means that sampling of systems that really evolve continuously is unavoidable; · although superficially straightforward, sampling can easily produce erroneous results when not treated properly; and · the need for a thorough understanding of many aspects of sampling among researchers and engineers dealing with applications to which they are central. The authors tackle many misconceptions which, although appearing reasonable at first sight, are in fact either partially or completely erroneous. They also deal with linear and nonlinear, deterministic and stochastic cases. The impact of the ideas presented on several standard problems in signals and systems is illustrated using a number of applications. Academic researchers and graduate students in systems, control and signal processing will find the ideas presented in Sampled-data Models for Linear and Nonlinear Systems to be a useful manual for dealing with sampled-data systems, clearing away mistaken ideas and bringing the subject thoroughly up to date. Researchers in statistics and economics will also derive benefit from the reworking of ideas relating a model derived from data sampling to an original continuous system.




Nonlinear Regression with R


Book Description

- Coherent and unified treatment of nonlinear regression with R. - Example-based approach. - Wide area of application.




Nonlinear Models for Repeated Measurement Data


Book Description

Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.




Generalized Linear Models


Book Description

Praise for the First Edition "The obvious enthusiasm of Myers, Montgomery, and Vining and their reliance on their many examples as a major focus of their pedagogy make Generalized Linear Models a joy to read. Every statistician working in any area of applied science should buy it and experience the excitement of these new approaches to familiar activities." —Technometrics Generalized Linear Models: With Applications in Engineering and the Sciences, Second Edition continues to provide a clear introduction to the theoretical foundations and key applications of generalized linear models (GLMs). Maintaining the same nontechnical approach as its predecessor, this update has been thoroughly extended to include the latest developments, relevant computational approaches, and modern examples from the fields of engineering and physical sciences. This new edition maintains its accessible approach to the topic by reviewing the various types of problems that support the use of GLMs and providing an overview of the basic, related concepts such as multiple linear regression, nonlinear regression, least squares, and the maximum likelihood estimation procedure. Incorporating the latest developments, new features of this Second Edition include: A new chapter on random effects and designs for GLMs A thoroughly revised chapter on logistic and Poisson regression, now with additional results on goodness of fit testing, nominal and ordinal responses, and overdispersion A new emphasis on GLM design, with added sections on designs for regression models and optimal designs for nonlinear regression models Expanded discussion of weighted least squares, including examples that illustrate how to estimate the weights Illustrations of R code to perform GLM analysis The authors demonstrate the diverse applications of GLMs through numerous examples, from classical applications in the fields of biology and biopharmaceuticals to more modern examples related to engineering and quality assurance. The Second Edition has been designed to demonstrate the growing computational nature of GLMs, as SAS®, Minitab®, JMP®, and R software packages are used throughout the book to demonstrate fitting and analysis of generalized linear models, perform inference, and conduct diagnostic checking. Numerous figures and screen shots illustrating computer output are provided, and a related FTP site houses supplementary material, including computer commands and additional data sets. Generalized Linear Models, Second Edition is an excellent book for courses on regression analysis and regression modeling at the upper-undergraduate and graduate level. It also serves as a valuable reference for engineers, scientists, and statisticians who must understand and apply GLMs in their work.




Partially Linear Models


Book Description

In the last ten years, there has been increasing interest and activity in the general area of partially linear regression smoothing in statistics. Many methods and techniques have been proposed and studied. This monograph hopes to bring an up-to-date presentation of the state of the art of partially linear regression techniques. The emphasis is on methodologies rather than on the theory, with a particular focus on applications of partially linear regression techniques to various statistical problems. These problems include least squares regression, asymptotically efficient estimation, bootstrap resampling, censored data analysis, linear measurement error models, nonlinear measurement models, nonlinear and nonparametric time series models.