Approach Based on Phenotype and EndotypeAsthma Diagnosis and Management


Book Description

Asthma is a severe and growing threat affecting both children and adults in both developing and developed world, currently affecting approximately 8% of US population. It is becoming increasingly recognized as a syndrome constituted by airway obstruction, airway hyperresponsiveness, and airway inflammation with different causes, associated risk factors, and underlying pathophysiology. The advances in basic and clinical research of asthma have accelerated over the past 20 years with increasing diagnostic tools, especially biomarkers, that led to specific characterization of individual patient's asthma pathophysiology, or disease "phenotype" and "endotype," which allowed precision medicine therapies, including new asthma biologics. This book aims to update the paradigm shifts in precision medicine of asthma diagnosis and management, driven by underlying phenotypes or endotypes.




Asthma Diagnosis and Management - Approach Based on Phenotype and Endotype


Book Description

Asthma is a severe and growing threat affecting both children and adults in both developing and developed world, currently affecting approximately 8% of US population. It is becoming increasingly recognized as a syndrome constituted by airway obstruction, airway hyperresponsiveness, and airway inflammation with different causes, associated risk factors, and underlying pathophysiology. The advances in basic and clinical research of asthma have accelerated over the past 20 years with increasing diagnostic tools, especially biomarkers, that led to specific characterization of individual patient's asthma pathophysiology, or disease ""phenotype"" and ""endotype,"" which allowed precision medicine therapies, including new asthma biologics. This book aims to update the paradigm shifts in precision medicine of asthma diagnosis and management, driven by underlying phenotypes or endotypes.




The Asthmas


Book Description

The field of asthma has expanded in the last decade with specific drugs targeting the disease mechanisms. This book is an updated treatise covering diagnoses, phenotypes and endotypes of asthma along with its management. It includes diagnostic work-up which is required prior to medical assistance and basic immunology assessment, illustrating the types, severity, number of exacerbations due to disease activity, allergy or infections. As the treatment selection has changed from one size fits all to precision-based medicine, it aims to refine asthma management with right medication usage, neither overuse nor underuse, and initiation of the new hospital administered biologic drugs. Key Features • Covers both respiratory physiology and airway inflammation • Highlights the use of biologic drugs • Discusses precision-based medicine • Explores the comorbidities through clinical cases




Advances in Asthma


Book Description

This book provides discussions on bronchial asthma from a clinical perspective, focusing on the recent studies on its pathophysiology, diagnosis and treatment. It also explores the lastest findings regarding the phenotypes and endotypes of asthmatic patients, making it of particular interest to those involved with non-eosinophilic asthma and eosinophilic asthma. Further, it discusses the importance of ILC 2 in eosinophilic asthma, and the accumulated results from the forced oscilliation technique and periostin that are actively practiced in Japan. As some aspects of diagnosis and treatment are different in Western and Asian countries, it is important that the data is disseminated around the globe. The clinical questions addressed by the authors are critical and thought provoking, while the questions raised by the editors are instructive, informative and provide new perspectives on unresolved issues. This book appeals to wide readership from beginning learners to physicians in clinical practice and scholars engaging in basic research.




Heterogeneity in Asthma


Book Description

Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. ​




Severe Asthma


Book Description

This book presents state of the art knowledge on severe asthma with the aim of providing readers with a clear understanding of, first, the heterogeneity of the condition and of patients’ symptom profiles and responses to therapy and, second, the future implications of this heterogeneity for individualized patient care. After an opening section that offers an overview of severe asthma, including its clinical significance, the pathogenesis, available diagnostic approaches, and treatment options are described in detail. The sections on diagnosis and treatment cover the role of biomarkers, the use of radiologic diagnostic modalities, and both pharmacologic and non-pharmacologic therapies, including emerging options that will address hitherto unmet needs of patients. The outcomes of cutting-edge preclinical and clinical research are carefully documented and numerous useful tips provided on patient management. The inclusion of many informative schematic figures will assist readers in grasping the contents easily. The book will be of high value for medical students, researchers, general physicians, specialists, and paramedical staff.




Asthma: A Multidisciplinary Approach, 2C (Clinics Collections)


Book Description

Clinics Collections: Asthma draws from Elsevier’s robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, pulmonologists, otolaryngologists, allergists, pediatricians, and other healthcare professionals, with practical clinical advice and insights on this highly prevalent disease and its comorbidities. Clinics Collections: Asthma guides readers on how to apply current primary research findings on asthma to everyday practice to help overcome challenges and complications, keep up with new and improved treatment methods, and improve patient outcomes. Areas of focus include pathogenesis, treatment and management of adult asthma, management of pediatric asthma, and special considerations. Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format. Elsevier Clinics Collections provide concise reviews of today’s most prevalent conditions and significant medical developments.




Severe Asthma


Book Description

Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.




Severe Asthma: Updated Therapy Approach Based on Phenotype and Biomarker


Book Description

Asthma is responsible for considerable global morbidity and health-care costs affecting over 300 million people worldwide. This illness is a heterogeneous condition characterized by chronic airway inflammation and pulmonary tissue remodeling resulting in a variety of clinical manifestations and treatment responses. Recent studies have shown an increasing appreciation of heterogeneity in asthma based on molecular phenotyping, biomarkers, and differential responses to therapies. In terms of asthma classification, perhaps the most important distinction to make is whether the patient has evidence of an eosinophilic inflammatory process characterized by type 2 immune response (Th2) or not. Therefore, personalized therapies to asthmatic patients just will be a reality by identifying and characterizing biomarkers. This review approaches the advances in diagnoses and management of asthma and severe asthma and highlights those with difficult-to-treat asthma based on each phenotype and biomarkers, to assist in the optimization of conventional therapy and to guide the use of targeted therapies.




Guidelines for the Diagnosis and Management of Asthma


Book Description

The National Institutes of Health Publication 07-4051, Guidelines for the Diagnosis and Management of Asthma, The EPR--3 Summary Report 2007, provides key information from the full report on the diagnosis and management of asthma. Summary information is provided on measures of assessment and monitoring, education for a partnership in asthma care, control of environmental factors and comorbid conditions that affect asthma, and medications. Key tables and figures from the full report are included for easy reference. Asthma is a chronic inflammatory disease of the airways. In the United States, asthma affects more than 22 million persons. It is one of the most common chronic diseases of childhood, affecting more than 6 million children (current asthma prevalence, National Health Interview Survey (NHIS), National Center for Health Statistics, Centers for Disease Control and Prevention, 2005) (NHIS 2005). There have been important gains since the release of the first National Asthma Education and Prevention Program (NAEPP) clinical practice guidelines in 1991. For example, the number of deaths due to asthma has declined, even in the face of an increasing prevalence of the disease (NHIS 2005); fewer patients who have asthma report limitations to activities; and an increasing proportion of people who have asthma receive formal patient education (Department of Health and Human Services, Healthy People 2010 midcourse review). Hospitalization rates have remained relatively stable over the last decade, with lower rates in some age groups but higher rates among young children 0–4 years of age. There is some indication that improved recognition of asthma among young children contributes to these rates. However, the burden of avoidable hospitalizations remains. Collectively, people who have asthma have more than 497,000 hospitalizations annually (NHIS 2005). Furthermore, ethnic and racial disparities in asthma burden persist, with significant impact on African American and Puerto Rican populations. The challenge remains to help all people who have asthma, particularly those at high risk, receive quality asthma care. Advances in science have led to an increased understanding of asthma and its mechanisms as well as improved treatment approaches. To help health care professionals bridge the gap between current knowledge and practice, the NAEPP of the National Heart, Lung, and Blood Institute (NHLBI) has previously convened three Expert Panels to prepare guidelines for the diagnosis and management of asthma. The NAEPP Coordinating Committee (CC), under the leadership of Claude Lenfant, M.D., Director of the NHLBI, convened the first Expert Panel in 1989. The charge to that Panel was to develop a report that would provide a general approach to diagnosing and managing asthma based on current science. Published in 1991, the “Expert Panel Report: Guidelines for the Diagnosis and Management of Asthma” (EPR 1991) organized the recommendations for the treatment of asthma around four components of effective asthma management: Use of objective measures of lung function to assess the severity of asthma and to monitor the course of therapy; Environmental control measures to avoid or eliminate factors that precipitate asthma symptoms or exacerbations; Patient education that fosters a partnership among the patient, his or her family, and clinicians; Comprehensive pharmacologic therapy for long-term management designed to reverse and prevent the airway inflammation characteristic of asthma as well as pharmacologic therapy to manage asthma exacerbations. The NAEPP recognizes that the value of clinical practice guidelines lies in their presentation of the best and most current evidence available. This report presents recommendations for the diagnosis and management of asthma that will help clinicians and patients make appropriate decisions about asthma care. ~