AUTOIMMUNE LIVER DISEASES: AUTOIMMUNE HEPATITIS, PBC, AND PSC, An Issue of Clinics in Liver Disease, E-Book


Book Description

In this issue of Clinics in Liver Disease, guest editor Dr. David E. Bernstein brings his considerable expertise to the topic of Autoimmune Hepatitis Including PBC and PSC. The three main immune disorders that involve the liver are AIH, primary biliary cholangitis, and primary sclerosing cholangitis. As these autoimmune diseases can share symptoms, it is important for the hepatologist to have clinical knowledge of each and understand their differences and similarities. This issue addresses these variants and provides the reader with important information relating to pathology, diagnosis, and treatment. - Contains 15 relevant, practice-oriented topics including autoimmune hepatitis: epidemiology, subtypes, and presentation; diagnosis of autoimmune hepatitis; treatment of autoimmune hepatitis including transplant; diagnostic tests in primary sclerosing cholangitis: serology, elastography, imaging; post-transplant management and complications of AIH, PBC, and PSC, including disease recurrence; and more. - Provides in-depth clinical reviews on autoimmune hepatitis, including PBC and PSC, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.




Autoimmune Liver Diseases


Book Description

The second edition, which appears seven years after the first, is a more comprehensive text and addresses the many recent advances in basic and clinical science applicable to autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune aspects of viral-, drug- and alcohol-induced liver disease and hepatocellular cancer. Pathogenesis, diagnosis and treatment are discussed in depth in light of current understanding of the molecular mechanisms of autoimmunity as it applies to liver disease.




Complications of Cirrhosis


Book Description

This volume presents a concise yet comprehensive overview on all facets concerning the complications of cirrhosis. Structured in three sections, the book reviews the natural history of cirrhosis, the diagnostic and predictive tools available to assess the disease, complications, and treatment options such as liver assist devices and transplantation. Topical concerns in the management of patients with cirrhosis are also addressed, including issues pertaining to the delivery of quality care in this patient population. Written by experts in their fields, Complications of Cirrhosis: Evaluation and Management serves as a valuable resource for practitioners and physicians-in-training on the subject of cirrhosis.




Hepatic Encephalopathy, An Issue of Clinics in Liver Disease, E-Book


Book Description

In this issue of Clinics in Liver Disease, guest editor Dr. Sammy Saab brings his considerable expertise to the topic of Hepatic Encephalopathy. Hepatic encephalopathy (HE) is a reversible syndrome in patients with advanced liver dysfunction, and is characterized by a wide spectrum of neuropsychiatric abnormalities resulting from the accumulation of neurotoxic substances in the brain. In this issue, top experts provide detailed clinical reviews devoted to the epidemiology, manifestations, and management of HE in the hopes of improving patient outcomes. - Contains 13 relevant, practice-oriented topics including clinical manifestations of HE; laboratory abnormalities of HE; pharmacologic management of HE; nontraditional treatment of HE; social impact of HE; future therapies of HE; and more. - Provides in-depth clinical reviews on hepatic encephalopathy, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.




Primary Biliary Cholangitis , An Issue of Clinics in Liver Disease, E-Book


Book Description

In this issue of Clinics in Liver Disease, guest editor Dr. John V. Binu brings his considerable expertise to the topic of Primary Biliary Cholangitis. PBC leads to inflammation and scarring of the small bile ducts, and, if untreated, can lead to cirrhosis and liver failure. In this issue, top experts provide a state-of-the-art review of diagnosis and treatment for this chronic, progressive liver disorder. - Contains 13 practice-oriented topics including genetics of primary biliary cholangitis; prognostic scoring systems in PBC; overlap syndromes and PBC; non-invasive evaluation of fibrosis and portal hypertension in PBC; treatment of PBC: first- and second-line therapies; novel therapies for PBC; and more. - Provides in-depth clinical reviews on primary biliary cholangitis, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.




Autoimmune Liver Diseases: Autoimmune Hepatitis, Pbc, and Psc, an Issue of Clinics in Liver Disease: Volume 28-1


Book Description

In this issue of Clinics in Liver Disease, guest editor Dr. David E. Bernstein brings his considerable expertise to the topic of Autoimmune Hepatitis Including PBC and PSC. The three main immune disorders that involve the liver are AIH, primary biliary cholangitis, and primary sclerosing cholangitis. As these autoimmune diseases can share symptoms, it is important for the hepatologist to have clinical knowledge of each and understand their differences and similarities. This issue addresses these variants and provides the reader with important information relating to pathology, diagnosis, and treatment. Contains 15 relevant, practice-oriented topics including autoimmune hepatitis: epidemiology, subtypes, and presentation; diagnosis of autoimmune hepatitis; treatment of autoimmune hepatitis including transplant; diagnostic tests in primary sclerosing cholangitis: serology, elastography, imaging; post-transplant management and complications of AIH, PBC, and PSC, including disease recurrence; and more. Provides in-depth clinical reviews on autoimmune hepatitis, including PBC and PSC, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.




Drug Hepatotoxicity,An Issue of Clinics in Liver Disease, E-Book


Book Description

In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Pierre Gholam has put together topics that provide a current clinical update on the treatment and management of patients with drug-induced liver injury (DILI). Expert authors have contributed clinical review articles on the following topics: Epidemiology, Predisposing Factors and Outcomes; Genetic Predisposition to DILI; Causality Assessment Frequent Offenders and Patterns of Injury; Quantitative Systems Toxicology Approaches to Understand and Predict DILI; Liver Histology: Diagnostic and Prognostic Features; Acute Liver Failure Secondary to DILI; DILI in Persons with Pre-existing Chronic Liver Disease; DILI in the Setting of Statin Use; DILI in the Setting of Analgesic Use; DILI Secondary to Herbals and Dietary Supplements; and DILI Reporting and Resources for the Clinician. Readers will come away with the information they need to improve outcomes in patients with DILI.




Pbc


Book Description

This is the Second Edition of this highly acclaimed book for people with the liver disease primary biliary cholangitis (PBC), fully updated and expanded in 2023 to take account of the substantial progress in the field over the three years since the publication of the first edition. This is the definitive guide to help patients with PBC beat the condition. Treatments for PBC have advanced rapidly in recent years and we are in a better position than ever to completely control it. With the information in this book you can make sure you are getting the best possible treatment, and find out what you can do to help yourself. Written by one of the world's leading experts on PBC, this book explains all aspects of the condition, from why people get it, to how it is diagnosed in the clinic, how it is treated and how you can beat the symptoms. It can be read as a thorough explanation; a textbook for patients. Alternatively, with "two-minute versions" for each of the chapters, you get can all the key facts quickly. The book also has a dictionary of PBC which will help you understand the technical terms and medical jargon that you may encounter. The book is also ideal for the relatives and partners of PBC patients to help them better understand their loved one's medical problems. It will also be really useful for students, doctors, nurses and other professionals who are encountering PBC for the first time and want to find out more. New for the second edition A chapter summarising what has changed in PBC in the three years since the first edition was published Extensive details of all the new and emerging drugs being used in trials in PBC More information on what the best management in clinic looks like and how to get it Expanded section on why people get fatigue and the new approaches to treating it in practice A frequently asked questions section directly answering the questions I get asked most frequently in clinic A revised look at the future of PBC taking on board all the recent advances A "know your numbers" section to help you understand how well your disease is controlled and to give you confidence in your discussions with doctors and nurses What people said about the first edition " An excellent book.....thank you for writing this" S "If you have PBC this is a must have book" C "This book is a bible for PBC" SS " This book is an absolute godsend......this amazing book is a must have for all PBC patients and their families" JP "An essential purchase" C "Professor Jones is amazing, thank you so much for writing this invaluable book" LE "Every piece of information you need to know and more is contained within this bible" PL




Portal Hypertension And Its Complications, An Issue of Clinics in Liver Disease, E-Book


Book Description

In this issue of Clinics in Liver Disease, guest editor Dr. Pierre M. Gholam brings his considerable expertise to the topic of Portal Hypertension and Its Complications. Portal hypertension is often one of the major complications seen in advanced liver disease. Patients can be asymptomatic for years and considered compensated. How to manage patients prior to the point of hepatic decompensation is of utmost importance, due to the impact on life expectancy and quality. The timely clinical reviews in this issue will help hepatologists manage these patients and improve outcomes. - Contains 12 relevant, practice-oriented topics including non-invasive assessment of portal hypertension; radiological and surgical treatments of portal hypertension; bleeding complications of portal hypertension; cognitive issues and portal hypertension; surgical considerations in portal hypertension; and more. - Provides in-depth clinical reviews on portal hypertension and its complications, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.




Drug-Induced Liver Injury


Book Description

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series