Discovering the Brain


Book Description

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."




Essence of Memory


Book Description

This selection of reviews gives an up-to-date picture of memory research. Great progress has been made in identifying the memory trace at the molecular and cellular level and individual reviews address the major mechanisms by which changes in synaptic strength can persist. Exciting research at the systems level is also reviewed including the growing importance of changes in inhibitory interneurons and how they play a role in memory formation. Finally, reviews present cognitive and neurobiological models of human memory that explain, characterize and organize the act of memory within a coherent framework. - Provides an unique overview that covers all perspectives and methodological approaches to memory - Broad coverage of memory research from molecular to human studies in one source - Up-to-date reviews give the latest important ideas on memory formation




Improving the Utility and Translation of Animal Models for Nervous System Disorders


Book Description

Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.




The Hippocampus Book


Book Description

The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.




The Science of Reading


Book Description

The Science of Reading: A Handbook brings together state-of-the-art reviews of reading research from leading names in the field, to create a highly authoritative, multidisciplinary overview of contemporary knowledge about reading and related skills. Provides comprehensive coverage of the subject, including theoretical approaches, reading processes, stage models of reading, cross-linguistic studies of reading, reading difficulties, the biology of reading, and reading instruction Divided into seven sections:Word Recognition Processes in Reading; Learning to Read and Spell; Reading Comprehension; Reading in Different Languages; Disorders of Reading and Spelling; Biological Bases of Reading; Teaching Reading Edited by well-respected senior figures in the field




Learning and Memory


Book Description

With its modular organization, consistent chapter structure, and contemporary perspective, this groundbreaking survey is ideal for courses on learning and memory, and is easily adaptable to courses that focus on either learning or memory. Instructors can assign the chapters they want from four distinctive modules (introduction, learning, memory, and integrative topics), with each chapter addressing behavioral processes, then the underlying neuroscience, then relevant clinical perspectives. The book is further distinguished by its full-color presentation and coverage that includes comparisons between studies of human and nonhuman brains. The new edition offers enhanced pedagogy and more coverage of animal learning.




Memory, Language, and Bilingualism


Book Description

A comprehensive and interdisciplinary approach to the study of memory, language and cognitive processing across various populations of bilingual speakers.




Basic Concepts and Models for Interpreter and Translator Training


Book Description

Basic Concepts and Models for Interpreter and Translator Training is a systematically corrected, enhanced and updated avatar of a book (1995) which is widely used in T&I training programmes worldwide and widely quoted in the international Translation Studies community. It provides readers with the conceptual bases required to understand both the principles and recurrent issues and difficulties in professional translation and interpreting, guiding them along from an introduction to fundamental communication issues in translation to a discussion of the usefulness of research about Translation, through discussions of loyalty and fidelity issues, translation and interpreting strategies and tactics and underlying norms, ad hoc knowledge acquisition, sources of errors in translation, T&I cognition and language availability. It takes on board recent developments as reflected in the literature and spells out and discusses links between practices and concepts in T&I and concepts and theories from cognitive psychology and psycholinguistics.




Corpora in Translation and Contrastive Research in the Digital Age


Book Description

Corpus-based contrastive and translation research are areas that keep evolving in the digital age, as the range of new corpus resources and tools expands, opening up to different approaches and application contexts. The current book contains a selection of papers which focus on corpora and translation research in the digital age, outlining some recent advances and explorations. After an introductory chapter which outlines language technologies applied to translation and interpreting with a view to identifying challenges and research opportunities, the first part of the book is devoted to current advances in the creation of new parallel corpora for under-researched areas, the development of tools to manage parallel corpora or as an alternative to parallel corpora, and new methodologies to improve existing translation memory systems. The contributions in the second part of the book address a number of cutting-edge linguistic issues in the area of contrastive discourse studies and translation analysis on the basis of comparable and parallel corpora in several languages such as English, German, Swedish, French, Italian, Spanish, Portuguese and Turkish, thus showcasing the richness of the linguistic diversity carried out in these recent investigations. Given the multiplicity of topics, methodologies and languages studied in the different chapters, the book will be of interest to a wide audience working in the fields of translation studies, contrastive linguistics and the automatic processing of language.