Biohealth


Book Description

The development of modern medicine is on a very steep trajectory upward--a rise that began only about a hundred years ago. This rise is certainly quantitative, but it is accompanied by qualitative changes in the way we understand and deliver healthcare. This book begins with a look at three recognized periods of medical development--from 1900 until World War II, from the war until about 1980, and the period since 1980. While the common response is to celebrate these developments, this book suggests that perhaps we should also be wary, especially of the qualitative changes. Since World War II, these medical developments have entered more and more areas of our lives. It is precisely this process of medicalization that should be critically examined. Since 1980 we have medicalized life itself. Drawing from medical sociology, the book examines four characteristics of contemporary Western health care: health as a system, risk as a means of understanding health, health as a commodity, and individual responsibility for health. Critical examination of these four tendencies in contemporary health care forms the core of the argument of this important book about the essence of biohealth and medical practice.




Biohealth


Book Description

The development of modern medicine is on a very steep trajectory upward--a rise that began only about a hundred years ago. This rise is certainly quantitative, but it is accompanied by qualitative changes in the way we understand and deliver healthcare. This book begins with a look at three recognized periods of medical development--from 1900 until World War II, from the war until about 1980, and the period since 1980. While the common response is to celebrate these developments, this book suggests that perhaps we should also be wary, especially of the qualitative changes. Since World War II, these medical developments have entered more and more areas of our lives. It is precisely this process of medicalization that should be critically examined. Since 1980 we have medicalized life itself. Drawing from medical sociology, the book examines four characteristics of contemporary Western health care: health as a system, risk as a means of understanding health, health as a commodity, and individual responsibility for health. Critical examination of these four tendencies in contemporary health care forms the core of the argument of this important book about the essence of biohealth and medical practice.




Optimization of Behavioral, Biobehavioral, and Biomedical Interventions


Book Description

This book presents a framework for development, optimization, and evaluation of behavioral, biobehavioral, and biomedical interventions. Behavioral, biobehavioral, and biomedical interventions are programs with the objective of improving and maintaining human health and well-being, broadly defined, in individuals, families, schools, organizations, or communities. These interventions may be aimed at, for example, preventing or treating disease, promoting physical and mental health, preventing violence, or improving academic achievement. This volume introduces the multiphase optimization strategy (MOST), pioneered at The Methodology Center at the Pennsylvania State University, as an alternative to the classical approach of relying solely on the randomized controlled trial (RCT). MOST borrows heavily from perspectives taken and approaches used in engineering, and also integrates concepts from statistics and behavioral science, including the RCT. As described in detail in this book, MOST consists of three phases: preparation, in which the conceptual model underlying the intervention is articulated; optimization, in which experimentation is used to gather the information necessary to identify the optimized intervention; and evaluation, in which the optimized intervention is evaluated in a standard RCT. Through numerous examples, the book demonstrates that MOST can be used to develop interventions that are more effective, efficient, economical, and scalable. Optimization of Behavioral, Biobehavioral, and Biomedical Interventions: The Multiphase Optimization Strategy is the first book to present a comprehensive introduction to MOST. It will be an essential resource for behavioral, biobehavioral, and biomedical scientists; statisticians, biostatisticians, and analysts working in epidemiology and public health; and graduate-level courses in development and evaluation of interventions.




Beyond Technonationalism


Book Description

The biomedical industry, which includes biopharmaceuticals, genomics and stem cell therapies, and medical devices, is among the fastest growing worldwide. While it has been an economic development target of many national governments, Asia is currently on track to reach the epicenter of this growth. What accounts for the rapid and sustained economic growth of biomedicals in Asia? To answer this question, Kathryn Ibata-Arens integrates global and national data with original fieldwork to present a conceptual framework that considers how national governments have managed key factors, like innovative capacity, government policy, and firm-level strategies. Taking China, India, Japan, and Singapore in turn, she compares each country's underlying competitive advantages. What emerges is an argument that countries pursuing networked technonationalism (NTN) effectively upgrade their capacity for innovation and encourage entrepreneurial activity in targeted industries. In contrast to countries that engage in classic technonationalism—like Japan's developmental state approach—networked technonationalists are global minded to outside markets, while remaining nationalistic within the domestic economy. By bringing together aggregate data at the global and national level with original fieldwork and drawing on rich cases, Ibata-Arens telegraphs implications for innovation policy and entrepreneurship strategy in Asia—and beyond.




Biomedical Computing


Book Description

Winner of the Computer History Museum Prize of the Special Interest Group: Computers, Information, and Society Imagine biology and medicine today without computers. What would laboratory work be like if electronic databases and statistical software did not exist? Would disciplines like genomics even be feasible if we lacked the means to manage and manipulate huge volumes of digital data? How would patients fare in a world absent CT scans, programmable pacemakers, and computerized medical records? Today, computers are a critical component of almost all research in biology and medicine. Yet, just fifty years ago, the study of life was by far the least digitized field of science, its living subject matter thought too complex and dynamic to be meaningfully analyzed by logic-driven computers. In this long-overdue study, historian Joseph November explores the early attempts, in the 1950s and 1960s, to computerize biomedical research in the United States. Computers and biomedical research are now so intimately connected that it is difficult to imagine when such critical work was offline. Biomedical Computing transports readers back to such a time and investigates how computers first appeared in the research lab and doctor's office. November examines the conditions that made possible the computerization of biology—including strong technological, institutional, and political support from the National Institutes of Health—and shows not only how digital technology transformed the life sciences but also how the intersection of the two led to important developments in computer architecture and software design. The history of this phenomenon has been only vaguely understood. November's thoroughly researched and lively study makes clear for readers the motives behind computerizing the study of life and how that technology profoundly affects biomedical research today.




The Common Marmoset in Captivity and Biomedical Research


Book Description

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the AmericanCollege of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset(Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such asmacaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. Themarmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primatemodel to study a number of poorly understood disorders, like autism. - Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications - Includes contributions from renowned and international authors and editors - Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series




Biostatistics for Medical and Biomedical Practitioners


Book Description

Biostatistics for Practitioners: An Interpretative Guide for Medicine and Biology deals with several aspects of statistics that are indispensable for researchers and students across the biomedical sciences. The book features a step-by-step approach, focusing on standard statistical tests, as well as discussions of the most common errors. The book is based on the author's 40+ years of teaching statistics to medical fellows and biomedical researchers across a wide range of fields. - Discusses how to use the standard statistical tests in the biomedical field, as well as how to make statistical inferences (t test, ANOVA, regression etc.) - Includes non-standards tests, including equivalence or non-inferiority testing, extreme value statistics, cross-over tests, and simple time series procedures such as the runs test and Cusums - Introduces procedures such as multiple regression, Poisson regression, meta-analysis and resampling statistics, and provides references for further studies




Nonhuman Primates in Biomedical Research


Book Description

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Diseases volume provides thorough reviews of naturally occurring diseases of nonhuman primates, with a section on biomedical models reviewing contemporary nonhuman primate models of human diseases. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. - Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in bioledical research - Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information - Includes four color images throughout




Implantable Biomedical Microsystems


Book Description

Research and innovation in areas such as circuits, microsystems, packaging, biocompatibility, miniaturization, power supplies, remote control, reliability, and lifespan are leading to a rapid increase in the range of devices and corresponding applications in the field of wearable and implantable biomedical microsystems, which are used for monitoring, diagnosing, and controlling the health conditions of the human body. This book provides comprehensive coverage of the fundamental design principles and validation for implantable microsystems, as well as several major application areas. Each component in an implantable device is described in details, and major case studies demonstrate how these systems can be optimized for specific design objectives. The case studies include applications of implantable neural signal processors, brain-machine interface (BMI) systems intended for both data recording and treatment, neural prosthesis, bladder pressure monitoring for treating urinary incontinence, implantable imaging devices for early detection and diagnosis of diseases as well as electrical conduction block of peripheral nerve for chronic pain management. Implantable Biomedical Microsystems is the first comprehensive coverage of bioimplantable system design providing an invaluable information source for researchers in Biomedical, Electrical, Computer, Systems, and Mechanical Engineering as well as engineers involved in design and development of wearable and implantable bioelectronic devices and, more generally, teams working on low-power microsystems and their corresponding wireless energy and data links. - First time comprehensive coverage of system-level and component-level design and engineering aspects for implantable microsystems. - Provides insight into a wide range of proven applications and application specific design trade-offs of bioimplantable systems, including several major case studies - Enables Engineers involved in development of implantable electronic systems to optimize applications for specific design objectives.




Introduction to Biomedical Engineering


Book Description

Under the direction of John Enderle, Susan Blanchard and Joe Bronzino, leaders in the field have contributed chapters on the most relevant subjects for biomedical engineering students. These chapters coincide with courses offered in all biomedical engineering programs so that it can be used at different levels for a variety of courses of this evolving field. Introduction to Biomedical Engineering, Second Edition provides a historical perspective of the major developments in the biomedical field. Also contained within are the fundamental principles underlying biomedical engineering design, analysis, and modeling procedures. The numerous examples, drill problems and exercises are used to reinforce concepts and develop problem-solving skills making this book an invaluable tool for all biomedical students and engineers. New to this edition: Computational Biology, Medical Imaging, Genomics and Bioinformatics.* 60% update from first edition to reflect the developing field of biomedical engineering* New chapters on Computational Biology, Medical Imaging, Genomics, and Bioinformatics* Companion site: http://intro-bme-book.bme.uconn.edu/* MATLAB and SIMULINK software used throughout to model and simulate dynamic systems* Numerous self-study homework problems and thorough cross-referencing for easy use