Blood Junction


Book Description

A Mystery Guild Featured Alternate In a stunning debut novel that won her the prestigious Crime Writers' Association New Writer's Award, Caroline Carver presents a gutwrenching, provocative adventure thriller set against the eerie, exotic backdrop of the Australian Outback--where a woman's search for the truth about horrific crimes will bring her to the crossroads of her life.




The Tight Junction and Its Proteins: More Than Just a Barrier


Book Description

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.




A Laboratory Guide to the Tight Junction


Book Description

A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases. - Provides consistent and detailed research methods - Covers various cell, tissue and animal models - Includes step-by-step guidance from beginner to sophisticated levels







Collected Papers


Book Description




The Esophagogastric Junction


Book Description

This book is the 5th in an exceptional series which, in a most uncommon way, constitutes an original encyclopaedia of esophagology. It is devoted to a single subject: the esophagogastric junction. These few centimetres are dissected into 420 questions which call on all the disciplines involved by its physiology, its diverse diseases and their various treatments. 450 answers, provided by the most renowned experts, each one shedding light on one small, but essential, fragment of the subject. The book offers: A succesion of syntheses; A profusion of targeted bibliographical references; An access, now made easy, to highly elaborated knowledge; A precious volume for researchers, specialists, departments heads, general practitioners and students.




Mims' Pathogenesis of Infectious Disease


Book Description

The newly revised edition of this work provides an up-to-date description of the mechanisms of infection and disease production in a clear and logical manner. Dealing in an integrated manner with all microorganisms, the factors common to all infectious diseases are set out. Molecular biology, pathology, and immunology are brought together to explain how an infectious agent causes disease, and how the body reacts to it. - Attachment to and entry of microorganisms - Events occurring immediately after entry - The encounter of the microbe with the phagocytic cell - The spread of microbes through the body - The immune response to infection - Microbial strategies in relation to the immune response - Mechanisms of cell and tissue damage - Recovery from infection - Failure to eliminate the microbe - Host and microbial factors influencing susceptibility - Vaccines




Dry Needling for Manual Therapists


Book Description

Designed to be a go-to reference for assessment and treatment planning in the clinic, this is a clear and concise handbook for students and practitioners of dry needling, or medical acupuncture. It includes: · Comprehensive medical illustrations demonstrating trigger point locations and associated pain referral patterns · Easy-to-follow instructions and photographs demonstrating musculoskeletal dry needling points and electroacupuncture techniques · Dedicated section on the acupuncture treatment of tendinopathy · Vital information on palpation and correct needling techniques · Practical guidance on best practice, safety and treatment planning · Overviews of the history and key principles of Traditional Chinese medicine and acupuncture · Up-to-date research on the effect of acupuncture in the treatment of MSK conditions, myofascial pain, trigger points (MTrPS), fascia and pain. The book will be an essential aid for osteopaths, physiotherapists, sports rehabilitators, chiropractors, massage therapists, as well as traditional acupuncturists wishing to understand a Western approach on acupuncture. Other health professionals incorporating, or looking to incorporate dry needling into their treatment programme, will also find this book an invaluable resource.




Homeostatic Control of Brain Function


Book Description

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health. Key Features include · A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks. · Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise. · Incorporation of homeostatic therapies into existing basic and clinical research paradigms. · Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis. · Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.