Author : Thomas H. Shepard
Publisher : JHU Press
Page : 564 pages
File Size : 12,22 MB
Release : 2004
Category : Medical
ISBN : 9780801879531
Links information on experimental teratogenic agents with the congenital defects in human beings.
Author : Jan Marshall Friedman
Publisher :
Page : 816 pages
File Size : 27,66 MB
Release : 2000
Category : Medical
ISBN :
"This new edition will continue to serve as a reference for use by clinical and research geneticists, teratologists, obstetricians, and pediatricians."--BOOK JACKET.
Author : T.V.N. Persaud
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 23,32 MB
Release : 2012-12-06
Category : Science
ISBN : 9401159106
The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. This book brings together some of the more recent and important research findings related to the mechanisms and pathogenesis of abnormal develop ment. It is not only a documentation of the latest experimental work, but it also points out future directions that seem productive and challenging.
Author : Hung N. Winn
Publisher : CRC Press
Page : 980 pages
File Size : 37,17 MB
Release : 2000-06-15
Category : Medical
ISBN : 9781850707981
Maternal-fetal medicine has evolved over the last three decades to become a well-established discipline. The current understanding of maternal physiology and pathophysiology has allowed us to obtain more accurate diagnoses and to provide more effective treatments of medical, surgical, and obstetrical maternal complications. More importantly, the fetus has become a distinct individual whose in utero environment has become much more accessible to study, diagnose, and treatment. Clinical Maternal-Fetal Medicine addresses the pathophysiology, diagnosis, and treatment of common medical and obstetrical maternal complications and fetal complications. It provides a concise and timely review of clinically relevant topics in this discipline. The textbook is a comprehensive reference covering the wide range of disciplines that make up maternal-fetal medicine.
Author : James Graves Wilson
Publisher :
Page : 328 pages
File Size : 24,94 MB
Release : 1973
Category : Medical
ISBN :
Author : Jack Botting
Publisher : Open Book Publishers
Page : 246 pages
File Size : 16,68 MB
Release : 2015-05-04
Category : Medical
ISBN : 1783741171
Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.
Author : V. Kolb Meyers
Publisher : Elsevier
Page : 485 pages
File Size : 24,81 MB
Release : 1988-01-01
Category : Medical
ISBN : 0080874908
This multi-author work deals with the practical aspects of teratogens - chemicals which cause birth defects. It is designed for use as a unique guide to these chemicals in which one can find all relevant information. The issues covered include: how to obtain information about the teratogenic potential of chemicals; teratogenic chemicals in undergraduate chemistry laboratories; safe handling of teratogenic chemicals; teratogenicity of pesticides and other pollutants in the environment; occupational exposure and pregnancy outcome; identification and prevention of reproductive hazards in industry; and the long-term effects of chemicals on the developing brain. A list of approximately 5,000 chemicals known to cause reproductive effects is given. A comprehensive bibliography is included with each chapter providing up-to-date references for more in-depth coverage. The monograph will be of interest to academic and industrial chemists, health professionals, as well as both undergraduate and graduate students in health and related sciences.
Author : Alison Fiander
Publisher : Cambridge University Press
Page : 557 pages
File Size : 29,77 MB
Release : 2016-10-13
Category : Education
ISBN : 1107667135
A fully updated and illustrated handbook providing comprehensive coverage of all curriculum areas covered by the MRCOG Part 1 examination.
Author : Jan Marshall Friedman
Publisher : Baltimore : Johns Hopkins University Press
Page : 676 pages
File Size : 11,48 MB
Release : 1996
Category : Abnormalities, Drug-Induced
ISBN :
"A pregnant woman should not take any drug unless it is necessary for her own health or that of her fetus," note J. M. Friedman and Janine Polifka. "Counseling a pregnant woman about possible effects of an environmental or drug exposure on her developing embryo or fetus is an important component of her medical care." Here, from the authors of the comprehensive catalog of the TERIS database--Teratogenic Effects of Drugs: A Resource for Clinicians--is a concise guide for physicians and other health care practitioners to the potential teratogenic risks of the 250 most commonly used prescription, over-the-counter, and recreational drugs. The Effects of Drugs on the Fetus and Nursing Infant presents agent summaries adapted from the TERIS database, including data on teratogenicity, transplacental carcinogenosis, embyronic or fetal death, and fetal and perinatal pharmacologic effects of drugs. The authors also discuss the effects that maternal use of such drugs during lactation may have on the nursing infant. "These careful and meticulous authors have created a top-notch teratogen reference book. It is inexpensive and convenient to transport and use and will be popular with physicians, clinical geneticists, and genetics counselors. I highly recommend this book." -- David D. Weaver, M.D., Indiana University Medical Center
Author : E.M. Johnson
Publisher : Springer Science & Business Media
Page : 379 pages
File Size : 17,64 MB
Release : 2012-12-06
Category : Medical
ISBN : 3642819192
The resolution of links between exposure to components of our complex environmental and causation of reproductive effects in the population constitutes an important problem in the field of toxicology. The focus of this volume is developmental toxicology, which represents one aspect of reproductive toxicology dealing with the study of adverse effects on the developing conceptus. Developmental toxicology, which includes teratogenesis as one of its manifesta tions, provides a fertile field for research in several basic and clinical disciplines; this field also receives input from several disoiplines such as developmental and molecu lar biology, pathology, pharmacology and toxicology, pediatrics and neonatology, and epidemiology. More recently we h~ve seen an emergence of interest in other fields such as perinatal physiology and postnatal behavior which have now become incorporated into the mainstream of research in this discipline. The present volume is an effort to provide a sampling of concepts currently under active investigation in several of the above fields. The authors have endeavored to provide up-to-date in formation on the following topics: detection and analysis of potential hazards to the conceptus in the workplace, pharmacokinetic aspects of the maternal/placental! fetal complex and its relationship to human birth defects, and probable mechanisms of teratogenesis as uncovered in certain well-defined situations. Also included are summaries of newer investigations on the emerging field of postnatal functional evaluations, i. e. , adverse effects on adult activities resultant from in utero exposure to toxic substances.
