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An Introduction to Tissue-Biomaterial Interactions

Author : Kay C. Dee

Publisher : John Wiley & Sons

Page : 250 pages

File Size : 24,56 MB

Release : 2003-04-14

Category : Science

ISBN : 0471461121

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Book Description

An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures. Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body’s wound-healing response is emphasized throughout. Specific topics covered include:Structure and properties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix. Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today’s and tomorrow’s implantable biomedical devices.





Anatomy and Physiology

Author : J. Gordon Betts

Publisher :

Page : 0 pages

File Size : 46,60 MB

Release : 2013-04-25

Category :

ISBN : 9781947172807

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Book Description



Capillary Fluid Exchange

Author : Joshua Scallan

Publisher : Morgan & Claypool Publishers

Page : 86 pages

File Size : 29,26 MB

Release : 2010

Category : Science

ISBN : 1615040668

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Book Description

The partition of fluid between the vascular and interstitial compartments is regulated by forces (hydrostatic and oncotic) operating across the microvascular walls and the surface areas of permeable structures comprising the endothelial barrier to fluid and solute exchange, as well as within the extracellular matrix and lymphatics. In addition to its role in the regulation of vascular volume, transcapillary fluid filtration also allows for continuous turnover of water bathing tissue cells, providing the medium for diffusional flux of oxygen and nutrients required for cellular metabolism and removal of metabolic byproducts. Transendothelial volume flow has also been shown to influence vascular smooth muscle tone in arterioles, hydraulic conductivity in capillaries, and neutrophil transmigration across postcapillary venules, while the flow of this filtrate through the interstitial spaces functions to modify the activities of parenchymal, resident tissue, and metastasizing tumor cells. Likewise, the flow of lymph, which is driven by capillary filtration, is important for the transport of immune and tumor cells, antigen delivery to lymph nodes, and for return of filtered fluid and extravasated proteins to the blood. Given this background, the aims of this treatise are to summarize our current understanding of the factors involved in the regulation of transcapillary fluid movement, how fluid movements across the endothelial barrier and through the interstitium and lymphatic vessels influence cell function and behavior, and the pathophysiology of edema formation. Table of Contents: Fluid Movement Across the Endothelial Barrier / The Interstitium / The Lymphatic Vasculature / Pathophysiology of Edema Formation



Biological Interactions on Materials Surfaces

Author : David A. Puleo

Publisher : Springer Science & Business Media

Page : 438 pages

File Size : 46,88 MB

Release : 2009-06-26

Category : Technology & Engineering

ISBN : 0387981616

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Book Description

Success or failure of biomaterials, whether tissue engineered constructs, joint and dental implants, vascular grafts, or heart valves, depends on molecular-level events that determine subsequent responses of cells and tissues. This book presents the latest developments and state-of-the-art knowledge regarding protein, cell, and tissue interactions with both conventional and nanophase materials. Insight into these biomaterial surface interactions will play a critical role in further developments in fields such as tissue engineering, regenerative medicine, and biocompatibility of implanted materials and devices. With chapters written by leaders in their respective fields, this compendium will be the authoritative source of information for scientists, engineers, and medical researchers seeking not only to understand but also to control tissue-biomaterial interactions.



Cell and Tissue Engineering

Author : Bojana Obradović

Publisher : Springer Science & Business Media

Page : 287 pages

File Size : 50,77 MB

Release : 2012-01-25

Category : Technology & Engineering

ISBN : 3642219136

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Book Description

“Cell and Tissue Engineering” introduces the principles and new approaches in cell and tissue engineering. It includes both the fundamentals and the current trends in cell and tissue engineering, in a way useful both to a novice and an expert in the field. The book is composed of 13 chapters all of which are written by the leading experts. It is organized to gradually assemble an insight in cell and tissue function starting form a molecular nano-level, extending to a cellular micro-level and finishing at the tissue macro-level. In specific, biological, physiological, biophysical, biochemical, medical, and engineering aspects are covered from the standpoint of the development of functional substitutes of biological tissues for potential clinical use. Topics in the area of cell engineering include cell membrane biophysics, structure and function of the cytoskeleton, cell-extracellular matrix interactions, and mechanotransduction. In the area of tissue engineering the focus is on the in vitro cultivation of functional tissue equivalents based on the integrated use of isolated cells, biomaterials, and bioreactors. The book also reviews novel techniques for cell and tissue imaging and characterization, some of which are described in detail such as atomic force microscopy. Finally, mathematical modeling methods are presented as valuable and indispensable tools in cell and tissue engineering. Numerous illustrations enhance the quality and ease of use of the presented material.



Cell and Tissue Reaction Engineering

Author : Regine Eibl

Publisher : Springer Science & Business Media

Page : 367 pages

File Size : 47,37 MB

Release : 2008-09-30

Category : Science

ISBN : 3540681825

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Book Description

The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.



Advanced Wound Repair Therapies

Author : David Farrar

Publisher : Elsevier

Page : 672 pages

File Size : 30,27 MB

Release : 2011-06-21

Category : Medical

ISBN : 0857093304

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Book Description

Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject. - Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds - Chapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healing - Covers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair



Principles and Practice of Laser Dentistry - E-Book

Author : Robert A. Convissar

Publisher : Elsevier Health Sciences

Page : 351 pages

File Size : 15,88 MB

Release : 2010-07-15

Category : Medical

ISBN : 032307989X

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Book Description

Expand your skills in the rapidly growing field of laser dentistry! Principles and Practice of Laser Dentistry uses a concise, evidence-based approach in describing protocols and procedures. Dr. Robert A. Convissar, a renowned lecturer on this subject, has assembled a diverse panel of international contributors; he’s also one of the first general dentists to use lasers in his practice. The book covers the history of lasers in dentistry and laser research, plus the use of lasers in periodontics, periodontal surgery, oral pathology, implantology, fixed and removable prosthetics, cosmetic procedures, endodontics, operative dentistry, pediatrics, orthodontics, and oral and maxillofacial surgery. Full-color images show the latest laser technology, surgical techniques, and key steps in patient treatment. Full-color photos and illustrations demonstrate surgical techniques and key teaching points. A Laser Fundamentals chapter describes the physics of lasers and the wavelengths that can produce better outcomes. Introducing Lasers into the Dental Practice chapter provides guidelines on investing in laser technology and in marketing this new procedure. Clinical Tip and Caution boxes include advice and alerts that can only be offered by a seasoned practitioner of 27 years.



Laser-Tissue Interactions

Author : Markolf H. Niemz

Publisher : Springer Science & Business Media

Page : 310 pages

File Size : 38,5 MB

Release : 2013-03-14

Category : Science

ISBN : 3662047179

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Book Description

Basic concepts such as the optical and thermal properties of tissue, the various types of tissue ablation, and optical breakdown and its related effects are treated in detail. Special attention is given to mathematical tools (Monte Carlo simulations, the Kubelka—Munk theory etc.) and approved techniques (photodynamic therapy, laser-induced interstitial thermotherapy etc.). The part on applications reviews clinically relevant methods in modern medicine using the latest references. The last chapter covers today’s standards of laser safety, with a careful selection of essential guidelines published by the Laser Institute of America. With numerous research photographs, illustrations, tables and comprehensive summaries.