Clinical Focus Series: Bone and Mineral Disorders


Book Description

Provides latest advances in diagnosis and management of bone and mineral disorders Part of the renowned Clinical Focus series Focus on skeletal and mineral homeostasis and the role of calcium and vitamin D as nutritional supplements Each chapter highly illustrated with tables and images Internationally recognised editor and author team led by US-based expert in the field







Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism


Book Description

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease. Visit the companion site to access supplementary materials including videos, editorial team details, downloadable figures, and more.




The Bone and Mineral Manual


Book Description

The Bone and Mineral Manual incorporates the most up-to-date laboratory methods, techniques, and approaches for designing strategies and investigating the pathophysiology of bone and mineral metabolism. It presents information in a succinct format that allows practitioners to find the answers they need quickly and easily--even while the patient encouter is still in progress. This practical guide will become a frequent companion of endocriniologists, bone and mineral specialists, and nephrologists. - Brings together current bone and mineral metabolism methods in one easily accessible volume - Provides a quick reference for immediate handling of bone and mineral disorders - Presents information in bullets, highlights, tables, and decision trees rather than lengthy text - Addresses problems likely to be seen at all ages, from pre-term infant to the centenarian - Ideal for practicing physicians, residents and medical students




Marcus and Feldman's Osteoporosis


Book Description

Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development. - Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents - Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis - Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders




Disorders of Bone & Mineral Metabolism - ECAB


Book Description

The skeleton is a metabolically active organ that undergoes continuous remodeling throughout life. This remodeling is necessary both to maintain the structural integrity of the skeleton and to fulfill its metabolic functions as a storehouse of calcium and phosphorus. Skeletal remodeling can be triggered by changes in mechanical forces or microdamage and by hormonal response to changes in circulating calcium and phosphorus levels. The skeleton also serves as the second line of defense against acidosis, and it is able to liberate buffers in the form of inorganic phosphates. Disorders of Bone and Mineral Metabolism is a multi-authored clinical update that covers all major aspects of bone and its mineral disorders. The first chapter is divided into different sections describing various minerals of clinical importance followed by regulation of mineral metabolism by parathyroid hormone, and vitamin D. There is a very good balance of basic information to act as a primer for the reader and the supporting experimental evidence. The complicated and often difficult topics of mineralization of bone and its regulation and other aspects of mineral metabolism are presented in a particularly clear and interesting manner. A long and useful bibliography follows every chapter. This update contains thorough discussions of the pathophysiology, diagnostic techniques, and therapy of mineral diseases with a wealth of detail. The book is a very useful reference for those interested in bone and mineral physiology and disease, be it a general physician or a nephrologist.




Clinical Focus Series: Disorders of Thyroid


Book Description

Part of the Clinical Focus series, this book is a comprehensive guide to the diagnosis and management of thyroid disorders. Divided into sixteen chapters, the book covers numerous disorders including hypothyroidism, Grave’s thyrotoxicosis, hyperthyroidism, thyroid nodules and cancer, and much more. Imaging and both medical and surgical treatment of thyroid disorders are discussed in depth, and the final sections of the book are dedicated to hypothyroidism in pregnancy, in juveniles, and in newborns. Written by experts in the field, led by Prof Romesh Khardori from Eastern Virginia Medical School, this practical guide is further enhanced by images and illustrations. Key points Comprehensive guide to diagnosis and management of thyroid disorders Covers numerous disorders, including those in pregnancy, in juveniles and newborns In depth discussion on thyroid imaging and both medical and surgical treatment Internationally recognised author team




ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism


Book Description

EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.




Metabolic Bone Disease and Clinically Related Disorders


Book Description

Metabolic Bone Disease, Third Edition is the new, expanded edition of the classic text, featuring the latest advancements and research information in this fast-moving field. The Third Edition includes the most up-to-date information on molecular mechanisms, basic biology, pathophysiology, and diagnosis and management strategies of metabolic bone disease. - Edited by "fathers of the field" - An expanded version of a classic AP text - Complete coverage of a fast-growing field




Genetics of Bone Biology and Skeletal Disease


Book Description

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. - Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments - Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders - Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder