Author : Nimesh G Desai
Publisher : Elsevier Health Sciences
Page : 108 pages
File Size : 24,66 MB
Release : 2014-12-11
Category : Medical
ISBN : 8131239497
Demystifying Depression: Complete Spectrum - ECAB
Author : Johan Normark
Publisher : Goteborg University
Page : 358 pages
File Size : 34,95 MB
Release : 2006
Category : Agent (Philosophy)
ISBN :
Author : B.E. Maryanoff
Publisher : Elsevier
Page : 338 pages
File Size : 13,43 MB
Release : 1999-04-01
Category : Science
ISBN : 0080526373
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
Author : Andrea Trabocchi
Publisher : John Wiley & Sons
Page : 550 pages
File Size : 12,88 MB
Release : 2013-06-17
Category : Science
ISBN : 1118618149
Discover an enhanced synthetic approach to developing and screening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developing large collections of structurally diverse small molecules as probes to investigate biological pathways. This book presents the most effective methods in diversity-oriented synthesis for creating small molecule collections. It offers tested and proven strategies for developing diversity-oriented synthetic libraries and screening methods for identifying ligands. Lastly, it explores some promising new applications based on diversity-oriented synthesis that have the potential to dramatically advance studies in drug discovery and chemical biology. Diversity-Oriented Synthesis begins with an introductory chapter that explores the basics, including a discussion of the relationship between diversity-oriented synthesis and classic combinatorial chemistry. Divided into four parts, the book: Offers key chemical methods for the generation of small molecules using diversity-oriented principles, including peptidomimetics and macrocycles Expands on the concept of diversity-oriented synthesis by describing chemical libraries Provides modern approaches to screening diversity-oriented synthetic libraries, including high-throughput and high-content screening, small molecule microarrays, and smart screening assays Presents the applications of diversity-oriented synthetic libraries and small molecules in drug discovery and chemical biology, reporting the results of key studies and forecasting the role of diversity-oriented synthesis in future biomedical research This book has been written and edited by leading international experts in organic synthesis and its applications. Their contributions are based on a thorough review of the current literature as well as their own firsthand experience developing synthetic methods and applications. Clearly written and extensively referenced, Diversity-Oriented Synthesis introduces novices to this highly promising field of research and serves as a springboard for experts to advance their own research studies and develop new applications.
Author : Martin C. Libicki
Publisher : Rand Corporation
Page : 115 pages
File Size : 38,71 MB
Release : 2013-05-13
Category : Computers
ISBN : 0833080059
Deterrence is possible only when others have at least a good idea of possible U.S. military reprisals, but cyberattack capabilities resist such demonstration. This report explores ways they can be and under what circumstances, then goes on to examine the difficulties and the drawbacks. Such "brandishing" is no panacea and could even backfire if misinterpreted. Its success also relies on the strength of other elements of the deterrence posture.
Author : Samuel Charap
Publisher : Rand Corporation
Page : 246 pages
File Size : 50,43 MB
Release : 2021-08-16
Category : History
ISBN : 1977407544
Understanding Russia’s grand strategy can help U.S. decisionmakers assess the depth and nature of potential conflicts between Russia and the United States and avoid strategic surprise by better-anticipating Moscow’s actions and reactions. The authors of this report review Russia’s declared grand strategy, evaluate the extent to which Russian behavior is consistent with stated strategy, and outline implications for the United States.
Author : David C. Klonoff
Publisher : Elsevier
Page : 311 pages
File Size : 38,24 MB
Release : 2020-04-04
Category : Medical
ISBN : 0128174862
Diabetes Digital Health brings together the multifaceted information surrounding the science of digital health from an academic, regulatory, industrial, investment and cybersecurity perspective. Clinicians and researchers who are developing and evaluating mobile apps for diabetes patients will find this essential reading, as will industry people whose companies are developing mobile apps and sensors. - Provides valuable information for clinicians, researchers and industry about the design and evaluation of patient-facing diabetes adherence technologies - Highlights cutting-edge topics that are presented and discussed at the Digital Diabetes Congress
Author : Gundu H. R. Rao
Publisher :
Page : 504 pages
File Size : 46,13 MB
Release : 2020
Category : Coronary heart disease
ISBN : 9789354653261
Author : TV Devarajan
Publisher : Jaypee Brothers,Medical Publishers Pvt. Limited
Page : 1264 pages
File Size : 35,18 MB
Release : 2017-04-20
Category : Medical
ISBN : 9789385999956
Author : Stefano Padulosi
Publisher : Routledge
Page : 466 pages
File Size : 25,76 MB
Release : 2021-09-22
Category : Nature
ISBN : 1000450422
Orphan Crops for Sustainable Food and Nutrition Security discusses the issues, challenges, needs and opportunities related to the promotion of orphan crops, known also as neglected and underutilized species (NUS). The book is structured into six parts, covering the following themes: introduction to NUS, approaches, methods and tools for the use enhancement of NUS, integrated conservation and use of minor millets, nutritional and food security roles of minor millets, stakeholders and global champions, and, building an enabling environment. Presenting a number of case studies at the regional and country levels, the chapters cover different but highly interlinked aspects along the value chains, from acquisition and characterization of genetic diversity, cultivation and harvesting to value addition, marketing, consumption and policy for mainstreaming. Cross-cutting issues like gender, capacity building and empowerment of vulnerable groups are also addressed by authors. Representatives from communities, research for development agencies and the private sector also share their reflections on the needs for the use enhancement of NUS from their own perspectives. This book will be of great interest to students and scholars of food security, sustainable agriculture, nutrition and health and development, as well as practitioners and policymakers involved in building more resilient food and production systems.
