Exercises in Synthetic Organic Chemistry


Book Description

The book is comprised of a series of exercises in synthetic organic chemistry based around recent published syntheses. The exercises are designed to provide challenges for people with varying levels of experience from final year students to academic staff and industrial group leaders, allowing them to increase their `vocabulary' of synthetic transformations. This novel approach, which actively involves the reader, would be an ideal source of topics for group discussions.




Exercises in Organic Synthesis Based on Synthetic Drugs


Book Description

Exercises in Organic Synthesis Based on Synthetic Drugs presents information on topics about the synthesis of biologically active compounds which are used against a range of diseases in both humans and animals. Topics are supplemented by notes and exercises for students to stimulate inquiry and learning in the academic environment. Readers will be equipped with basic knowledge of synthetic techniques used in organic chemistry and pharmaceutical research and development. Key Features: - Presents information about different techniques and strategies for the synthesis of organic compounds - Covers a broad range of biologically active compounds - Easy to read topical presentation - Exercises, with answers, designed for improving concepts in organic synthesis and medicinal chemistry - Wide range of bibliographic references for further reading and exercises presented, Exercises in Organic Synthesis Based on Synthetic Drugs is an essential textbook for students in beginner level courses in organic chemistry, organic synthesis and medicinal chemistry.




Two Hundred Exercises in Mechanistic Organic Chemistry


Book Description

This book will strengthen the knowledge of mechanistic organic chemistry for organic chemists who have completed a bachelor's degree and want to start researching in a laboratory or working in a chemical company. Hardly ever does an organic synthesis advance according to plan. Diligently designed synthetic schemes stumble upon the laboratory reality of meagre yields, side reactions, and unwanted products. To fight against that we have a magnificent intellectual tool: reaction mechanisms. In the course of an undergraduate degree, the student assimilates an assortment of unadorned reaction mechanisms, when in professional practice she/he needs to envision convoluted mechanisms resulting from the sequential operation of simple steps. The student here is like the novice chess player who knows how to move the pieces, but not how to play the game. This book facilitates that learning in mechanistic organic chemistry, a fundamental apprenticeship for the preparation of new drugs that save millions of lives.




Multi-Step Organic Synthesis


Book Description

Combining theoretical knowledge of synthetic transformations, practical considerations, structural elucidation by interpretation of spectroscopic data as well as rationalization of structure-property relations, this textbook presents a series of 16 independent exercises, including detailed descriptions of experimental procedures, questions, and answers. The experimental descriptions are very helpful for guiding less experienced students towards a better understanding of practical aspects in synthetic organic chemistry, while the broad scope of the questions and answers is excellent for learning purposes. The exercises are based on published research articles, adapted for didactic purposes, and will thus inspire students by way of having to solve real-life problems in chemistry. A must-have for MSc and PhD students as well as postdocs in organic chemistry and related disciplines, and lecturers and organizers of lab courses in organic chemistry.




Exercises in Synthetic Organic Chemistry


Book Description

This book is comprised of a series of exercises in synthetic organic chemistry based around recently published syntheses. Each exercise gives a reference to the original work, a synthetic scheme in which either structures or reagents have been omitted, a series of questions on the exercise, and in most cases references to related literature and useful reviews. The exercises are designed to provide challenges for people with a wide range of backgrounds, from undergraduates to academic staff and industrial group leaders, and they enable readers to increase their vocabulary of synthetic transformations. Taking a novel approach, this volume encourages active participation; instead of absorbing standard strategies, readers are asked to propose solutions to set problems. The exercises are ideal for group discussions in organic chemistry.







Classics in Total Synthesis


Book Description

K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.




Two Hundred Exercises in Mechanistic Organic Chemistry


Book Description

This book will strengthen the knowledge of mechanistic organic chemistry for organic chemists who have completed a bachelor’s degree and want to start researching in a laboratory or working in a chemical company. Hardly ever does an organic synthesis advance according to plan. Diligently designed synthetic schemes stumble upon the laboratory reality of meagre yields, side reactions, and unwanted products. To fight against that we have a magnificent intellectual tool: reaction mechanisms. In the course of an undergraduate degree, the student assimilates an assortment of unadorned reaction mechanisms, when in professional practice she/he needs to envision convoluted mechanisms resulting from the sequential operation of simple steps. The student here is like the novice chess player who knows how to move the pieces, but not how to play the game. This book facilitates that learning in mechanistic organic chemistry, a fundamental apprenticeship for the preparation of new drugs that save millions of lives.




Advanced Organic Chemistry


Book Description

The two-part, fifth edition of Advanced Organic Chemistry has been substantially revised and reorganized for greater clarity. The material has been updated to reflect advances in the field since the previous edition, especially in computational chemistry. Part A covers fundamental structural topics and basic mechanistic types. It can stand-alone; together, with Part B: Reaction and Synthesis, the two volumes provide a comprehensive foundation for the study in organic chemistry. Companion websites provide digital models for study of structure, reaction and selectivity for students and exercise solutions for instructors.




Organic Synthesis Workbook


Book Description

From the Foreword written by Erick M. Carreira: "... The Organic Synthesis Workbook is an ideal compilation of state-of-the art modern syntheses which wonderfully showcases the latest advances in synthetic chemistry in combination with fundamentals in a question-and-answer format. The structure of the book is such that the reader can appreciate the intricacies of strategic planning, reagent tailoring, and structural analysis within the context of the individual synthetic targets. In providing highlights of synthesis from a wider range of natural products classes (alkaloids, terpenes, macrolides) the reader is given a tour through a broad range of reaction chemistry and concepts. Moreover, because in its scope the authors have ignored international borders, the book effectively parlays the global aspect of current research in the exciting field of organic synthesis... The Organic Synthesis Workbook promises to be to the current generation of graduate students, and even "students-for-life", what Ireland's and Alonso's books were to those of us who were graduate students in the 80's [Alsono: The Art of Problem Solving in Organic Chemistry, Ireland: Organic Synthesis]. The authors have wonderfully captured the thrill, the enjoyment, and the intellectual rigor that is so characteristic of modern synthetic organic chemistry."