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Handbook of Metabolic Pathways of Xenobiotics

Author : Philip Lee

Publisher : Wiley

Page : 2560 pages

File Size : 45,67 MB

Release : 2014-03-17

Category : Science

ISBN : 9780470749104

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Book Description

If you’re working on or studying the effects of drug metabolisms, then this reference is for you! Handbook of Metabolic Pathways of Xenobiotics is an essential new reference which presents the metabolic fate of xenobiotics in animals and plants, and shows the metabolic pathways in the environment. Presenting a comprehensive guide to understanding the metabolisms of xenobiotics, the Handbook of Metabolic Pathways of Xenobiotics spans five volumes: Volumes 1-2 are Review Articles and Volumes 3-5 are Compound Articles. Review Articles present detailed reviews on the techniques and methods used to establish in vitro and in vivo metabolic pathways. Compound Articles are carefully selected lists of key chemicals representing agrochemicals, pharmaceuticals, animal health products and industrial chemicals. An essential addition to every library, this introduction, guide and catalogue presents: Current topics in the metabolism of xenobiotics Topics of both scientific and regulatory importance are covered, including in vitro high throughput metabolism screens, computer-aided metabolism predictions, and advances in bioanalytical techniques. Techniques and methods used in metabolic pathways 29 chapters provide an introduction to the understanding of drug metabolism and detail how to establish in vitro and in vivo metabolic pathways. Biotransformation pathways Presented as a catalogue of short articles covering major pharmaceuticals, agrochemicals, animal health products and industrial chemicals. Each article summarizes the chemical properties and uses, and presents a detailed review of the chemical and metabolic pathways in soil, plants and animals. Over 450 examples of xenobiotics and their fate in animals and plants Each compound includes systematic information about the metabolic pathway of drugs for human and veterinary medicine, agrochemicals and major industrial chemicals. Chemical and biological fate data The Handbook summarises data from scientific literature, patent literature, industrial resources and regulatory agencies, such as the EPA, FDA, EU, WHO and FAO, in a single reference for the first time. An essential reference for everyone working and studying pharmacokinetics and drug metabolism Coverage of the chemical and biological reactivity of molecules and primary sub-structures makes this an ideal reference for students and research scientists. The broad and diverse coverage of chemical and biological fate under different exposure and biological compartments make this a useful resource for regulatory and developmental scientists. Experience the scope of content offered in the Handbook of Metabolic Pathways of Xenobiotics for yourself, download these articles today: Review Article: Fundamentals of organic chemistry as applicable to the biotransformation of foreign compounds Review Article: Metabolic stability screen in drug discovery Review Article: Unusual metabolic reactions and pathways Compound Article: Ganoderic acid D Compound Article: Milnacipran Compound Article: Tenofovir Online Edition Coming Soon! Featuring the same great content as the five volume print set, the Handbook of Metabolic Pathways for Xenobiotics will be available on Wiley Online Library in summer 2014. The online reference will benefit from the enhanced functionality powered by The Smart Article – learn more about The Smart Article at wileyonlinelibrary.com/thesmartarticle. Free trials will be available when the Online Edition goes live, bookmark this page or sign-up for regular product alerts at www.wiley.com/email to stay informed.



Metabolism of Drugs and Other Xenobiotics

Author : Pavel Anzenbacher

Publisher : John Wiley & Sons

Page : 755 pages

File Size : 42,58 MB

Release : 2012-05-29

Category : Medical

ISBN : 352732903X

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Book Description

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.



Nutrient Metabolism

Author : Martin Kohlmeier

Publisher : Academic Press

Page : 899 pages

File Size : 46,21 MB

Release : 2015-05-12

Category : Technology & Engineering

ISBN : 0123877881

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Book Description

Nutrient Metabolism, Second Edition, provides a comprehensive overview of the supply and use of nutrients in the human body and how the body regulates intake. Chapters detail the principles determining digestion and absorption of food ingredients and how these compounds and their metabolites get into the brain, cross the placenta and pass through the kidneys. Each nutrient's coverage contains a nutritional summary that describes its function, its food sources, dietary requirements, potential health risks if deficient, and impact of excessive intake. This handbook contains the latest information on the scope of structures, processes, genes and cofactors involved in maintaining a healthy balance of nutrient supplies. Of interest to a wide range of professionals because nutrient issues connect to so many audiences, the book contains a useful link to dietary supplements. - Latest research findings on health and clinical effects of nutrients and of interventions affecting nutrient supply or metabolism - Each nutrient covered contains a nutritional summary describing its function, food sources, dietary requirements, potential health risks if deficient, and impact of excessive intake. - Nutrient information immediately accessible--from source to effect--in one volume



Handbook on the Toxicology of Metals: Specific metals

Author : Lars Friberg

Publisher : Elsevier Science & Technology

Page : 758 pages

File Size : 31,84 MB

Release : 1986

Category : Medical

ISBN :

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Book Description

Chapters on specific metals include physical and chemical properties, methods and problems of analysis, production and uses, environmental levels and exposures, metabolism, levels in tissues and biological fluids, effects and dose-response relationships, carcinogenicity, mutagenicity, teratogenicity and preventative measures, diagnosis, treatment and prognosis.



Medical Biochemistry

Author : Antonio Blanco

Publisher : Academic Press

Page : 910 pages

File Size : 15,92 MB

Release : 2022-03-23

Category : Science

ISBN : 0323916007

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Book Description

This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language. This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis. The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance. - Integrates basic biochemistry principles with molecular biology and molecular physiology - Illustrates basic biochemical concepts through medical and physiological examples - Utilizes a systems approach to understanding biological phenomena - Fully updated for recent studies and expanded to include clinically relevant examples and succinct chapter summaries



How Tobacco Smoke Causes Disease

Author : United States. Public Health Service. Office of the Surgeon General

Publisher :

Page : 728 pages

File Size : 14,71 MB

Release : 2010

Category : Government publications

ISBN :

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Book Description

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.



Drug Metabolism

Author : Mino R. Caira

Publisher : Springer Science & Business Media

Page : 431 pages

File Size : 42,82 MB

Release : 2006-07-10

Category : Medical

ISBN : 140204142X

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Book Description

Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.



The Handbook of Polyhydroxyalkanoates, Three Volume Set

Author : Martin Koller

Publisher : CRC Press

Page : 1416 pages

File Size : 16,42 MB

Release : 2020-11-06

Category : Medical

ISBN : 1000173593

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Book Description

The Handbook of Polyhydroxyalkanoates (PHA) focusses on and addresses varying facets of PHA biosynthesis and processing, spread across three volumes. The first volume discusses feedstock aspects, enzymology, metabolism and genetic engineering of PHA biosynthesis. It addresses better understanding the mechanisms of PHA biosynthesis in scientific terms and profiting from this understanding in order to enhance PHA biosynthesis in bio-technological terms and in terms of PHA microstructure. It further discusses making PHA competitive for outperforming established petrol-based plastics on industrial scale and obstacles for market penetration of PHA. This second volume focusses on thermodynamic and mathematical considerations of PHA biosynthesis, bioengineering aspects regarding bioreactor design and downstream processing for PHA recovery from microbial biomass. It covers microbial mixed culture processes and includes a strong industry-focused section with chapters on the economics of PHA production, industrial-scale PHA production from sucrose, next generation industrial biotechnology approaches for PHA production based on novel robust production strains, and holistic techno-economic and sustainability considerations on PHA manufacturing. Third volume is on the production of functionalized PHA bio-polyesters, the post-synthetic modification of PHA, processing and additive manufacturing of PHA, development and properties of PHA-based (bio)composites and blends, the market potential of PHA and follow-up materials, different bulk- and niche applications of PHA, and the fate and use of spent PHA items. Divided into fourteen chapters, it describes functionalized PHA and PHA modification, processing and their application including degradation of spent PHA-based products and fate of these bio-polyesters during compositing and other disposal strategies. Aimed at professionals and graduate students in Polymer (plastic) industry, wastewater treatment plants, food industry, biodiesel industry, this set: Presents comprehensive and holistic consideration of these microbial bioplastics in the volumes. Enables reader to learn about microbiological, enzymatic, genetic, synthetic biology, and metabolic aspects of PHA biosynthesis based on the latest scientific discoveries. Discusses design and operate a PHA production plant. Strong focus on post-synthetic modification, preparation of functional PHA and follow-up products, and PHA processing. Covers all related engineering considerations



The Metabolic Pathway Engineering Handbook

Author : Christina Smolke

Publisher : CRC Press

Page : 680 pages

File Size : 22,22 MB

Release : 2009-07-28

Category : Medical

ISBN : 1439802971

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Book Description

This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction



Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

Author : Institute of Medicine

Publisher : National Academies Press

Page : 530 pages

File Size : 16,51 MB

Release : 2000-08-27

Category : Medical

ISBN : 0309069491

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Book Description

This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.