Synthetic Immunology


Book Description

This book reviews the emerging studies of synthetic immunology, including the development and regeneration of immune cells, immune organ development and artificial regeneration, and the synthetic approach towards understanding human immune system. Immunology has developed rapidly over the last 50 years through the incorporation of new methods and concepts in cell and molecular biology, genetics, genomics and proteomics. This progress is the result of works by many excellent researchers all over the world. Currently, immunological research has accumulated detailed knowledge on basic mechanisms of immunity and is in the process to change medical practices. Yet, due to the enormous complexity of the immune system, many aspects on the regulation and function of this system remain unknown. Synthetic biology uses gain-of-function rather than loss-of-function approaches. The goals of synthetic biology can be described in a simple phrase “rebuild, alter, and understand,” namely, to rebuild minimal functional systems using well-defined parts from nature and then to perturb the system to understand its working principles. Given the richness of accumulated knowledge in molecular and cellular mechanisms of the immune system, we now begin adapting the concepts of synthetic biology to immunology. An immune response is a spatiotemporal phenomenon occurring at a given time and at a specialized place in the body. One goal of synthetic immunology is to reconstruct artificial microenvironments for better understanding of an immune response. We hope this yet-to-be-experimental approach of synthetic immunology and the compilation of this book will aid our further understanding of the immune system and future devising the tools to manipulate the immune system for therapy and prevention of the diseases.




Multitrophic Level Interactions


Book Description

The multitrophic level approach to ecology addresses the complexity of food webs much more realistically than the traditional focus on simple systems and interactions. Only in the last few decades have ecologists become interested in the nature of more complex systems including tritrophic interactions between plants, herbivores and natural enemies. Plants may directly influence the behaviour of their herbivores' natural enemies, ecological interactions between two species are often indirectly mediated by a third species, landscape structure directly affects local tritrophic interactions and below-ground food webs are vital to above-ground organisms. The relative importance of top-down effects (control by predators) and bottom-up effects (control by resources) must also be determined. These interactions are explored in this exciting volume by expert researchers from a variety of ecological fields. This book provides a much-needed synthesis of multitrophic level interactions and serves as a guide for future research for ecologists of all descriptions.




Saproxylic Insects


Book Description

This volume offers extensive information on insect life in dying and dead wood. Written and reviewed by leading experts from around the world, the twenty-five chapters included here provide the most global coverage possible and specifically address less-studied taxa and topics. An overarching goal of this work is to unite literature that has become fragmented along taxonomic and geographic lines. A particular effort was made to recognize the dominant roles that social insects (e.g., termites, ants and passalid beetles) play in saproxylic assemblages in many parts of the world without overlooking the non-social members of these communities. The book is divided into four parts: · Part I “Diversity” includes chapters addressing the major orders of saproxylic insects (Coleoptera, Diptera, Hymenoptera, Hemiptera, Lepidoptera and Blattodea), broadly organized in decreasing order of estimated global saproxylic diversity. In addition to order-level treatments, some chapters in this part discuss groups of particular interest, including pollinators, hymenopteran parasitoids, ants, stag and passalid beetles, and wood-feeding termites. · Part II “Ecology” discusses insect-fungal and insect-insect interactions, nutritional ecology, dispersal, seasonality, and vertical stratification. · Part III “Conservation” focuses on the importance of primary forests for saproxylic insects, offers recommendations for conserving these organisms in managed forests, discusses the relationships between saproxylic insects and fire, and addresses the value of tree hollows and highly-decomposed wood for saproxylic insects. Utilization of non-native wood by saproxylic insects and the suitability of urban environments for these organisms are also covered. · Lastly, Part IV “Methodological Advancements” highlights molecular tools for assessing saproxylic diversity. The book offers an accessible and insightful resource for natural historians of all kinds and will especially appeal to entomologists, ecologists, conservationists and foresters.




Pine Bark Beetles


Book Description

Pine Bark Beetles, the latest release in the Advances in Insect Physiology series, provides readers with the latest interdisciplinary reviews on the topic. It is an essential reference source for invertebrate physiologists, neurobiologists, entomologists, zoologists, and insect chemists. - Contains important, comprehensive, and in-depth reviews on insect physiology - Provides an essential reference source for invertebrate physiologists and neurobiologists, entomologists, zoologists, and insect biochemists - First published in 1963, this serial is ranked second in the highly competitive ISI category of entomology




Alphaherpesviruses


Book Description

Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.




Insect Communication


Book Description







Immunity in Insects


Book Description

This volume details methods and protocols necessary to further the study of insect immunity. Chapters guide readers through up-to-date genomic and transcriptomic approaches, insect samples for proteomic analysis, hemocytes in Drosophila, cellular response in Lepidoptera, insect AMPs, manipulate the composition of mosquito microbiota, viral infections in insects, infections by entomopathogenic nematodes, immune response following oral infections, and protocols to to monitor the effect of septic infections with human pathogens using B. mori as a model. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Immunity in Insects aims to ensure successful results in the further study of this vital field.Incl .




Honey Bee Colony Health


Book Description

This book summarizes the current progress of bee researchers investigating the status of honey bees and possible reasons for their decline, providing a basis for establishing management methods that maintain colony health. Integrating discussion of Colony Collapse Disorder, the chapters provide information on the new microsporidian Nosema ceranae pathogens, the current status of the parasitic bee mites, updates on bee viruses, and the effects these problems are having on our important bee pollinators. The text also presents methods for diagnosing diseases and includes color illustrations and tables.




Insect Development


Book Description