Human and Environmental Risks of Chlorinated Dioxins and Related Compounds


Book Description

Increasing international concern is being expressed regarding the contamination of the environment with polychlorinated dibenzo-p dioxins (PCDDs) and polychlorinated dibenzofurans because certain of these chemicals have been shown to be highly toxic to animals and are ubiquitous in the environment. They are known to be distributed as contaminants of commercial products and as by-products from com bustion processes. A considerable volume of information has accumulated on these chemicals in the past two decades, particularly for the most toxic of them, 2,3,7,8-tetrach1orodibenzo-p-dioxin (2,3,7,8-TCDD). However, this body of knowledge has not succeeded in resolving genuine judgmental differences among experts in the field as to the degree of hazard to human health and the environment. In light of the widespread public concern, it is clearly imperative to come to grips with the continuing scientific controversy, to review the data, assess the issues, to see where areas of agreement exist, and where further research is needed to resolve remaining areas of disagree ment. This volume represents an effort to contribute to these goals.




EPA National Publications Catalog


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EPA National Publications Catalog


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EPA 200-B.


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The Basis of Toxicity Testing


Book Description

This substantially updated edition presents fundamental principles and concepts behind the various types of toxicological studies, and explains how to design and conduct studies and interpret results. The text explains the increasing need to monitor, assess, and reevaluate the toxicity database of many agents and evaluates the place of individual studies in the overall toxicological assessment of a chemical. Concise descriptions of the formats of in vivo and in vitro studies and methods used in assessing endpoints of toxicity make this an essential introduction and guide for anyone who needs to understand or conduct toxicological studies. Reflecting increasing interest in the "Three Rs" (Reducing, Refining, and Replacement of existing animal tests) in recent years, the Second Edition includes much more information on a variety of new alternative testing protocols. Particular attention is given to the new in vitro alternative testing procedures being incorporated into EEC regulations. The text also covers studies required by regulatory agencies around the world.




How Much Is Clean Air Worth?


Book Description

How Much Is Clean Air Worth? offers readers a comprehensive overview of the core methodologies and tools used to quantify the impacts and damage costs of pollution. The book begins by reviewing the tools used for environmental assessments and shows that a rational approach requires an impact pathway analysis (IPA) for each of the possible impacts of a pollutant, i.e. an analysis of the chain emission -> dispersion -> exposure-response functions -> monetary valuation. The IPA methodology is explained in full and illustrated with worked examples, and difficulties are discussed and uncertainties analysed. In addition to detailed computer models, a very simple model (the 'Uniform World Model') is presented, enabling readers to make estimates for cases where no results are available. Published results for electricity, waste treatment and transport are reviewed, with a thorough discussion of policy implications. This book will appeal to a broad mix of academics, graduate students and practitioners in government and industry working on cost-benefit analysis, environmental impact analysis and environmental policy.




Federal Register


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