Heterogeneity Within the Stem Cell Compartment
Author : Jonathon M. Carr
Publisher :
Page : pages
File Size : 42,27 MB
Release : 2018
Category :
ISBN :
Author : Jonathon M. Carr
Publisher :
Page : pages
File Size : 42,27 MB
Release : 2018
Category :
ISBN :
Author : Alexander Birbrair
Publisher : Springer Nature
Page : 266 pages
File Size : 39,41 MB
Release : 2019-09-05
Category : Science
ISBN : 3030241084
This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue. As the functions of these stem cells vary, this is very important for the application of stem cells in cell therapy. This book describes the many recent developments that have revealed completely different roles of distinct stem cells within the same organ. Stem Cells Heterogeneity in Different Organs provides a timely update on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. Taken with its companion volumes, Stem Cells Heterogeneity: Novel Concepts and Stem Cells Heterogeneity in Cancer, this book is essential reading for advanced cell biology students as well as researchers and clinicians working with stem cells.
Author : Alexander Birbrair
Publisher : Springer
Page : 225 pages
File Size : 24,26 MB
Release : 2019-04-23
Category : Science
ISBN : 3030110966
This book presents a comprehensive discussion on the novel concepts in stem cell heterogeneity, from pluripotent stem cells to human mesenchymal stem cells, adult and cancer stem cells of the thyroid, sarcoma, and more. Thus, Stem Cell Heterogeneity - Novel Concepts starts from a timely update on the current information on stem cells heterogeneity in various tissues and discusses new concepts and future directions. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity in Different Organs, and Stem Cells Heterogeneity in Cancer, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.
Author : Alexander Birbrair
Publisher : Springer
Page : 228 pages
File Size : 38,30 MB
Release : 2019-05-27
Category : Science
ISBN : 303014366X
This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue, for several types of cancers, e.g. glioblastoma stem cells. Recent developments have revealed completely different roles of distinct stem cells within the same organ. Thus, Stem Cells Heterogeneity in Cancer provides a timely update us on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. When taken as a whole, alongside its companion volumes Stem Cells Heterogeneity – Novel Concepts, and Stem Cells Heterogeneity in Different Organs, these three books present a comprehensive reference on stem cell heterogeneity in various tissues and current and future applications for regenerative medicine. It is essential reading for advanced cell biology students as well as researchers in stem cells and clinicians.
Author : Sarah Jacob Eshtan
Publisher :
Page : pages
File Size : 22,42 MB
Release : 2014
Category :
ISBN :
Author :
Publisher :
Page : 272 pages
File Size : 37,85 MB
Release : 2019
Category : Stem cells
ISBN : 9783030241094
This book presents a comprehensive discussion on the heterogeneity existing between different types of stem cells within the same tissue. As the functions of these stem cells vary, this is very important for the application of stem cells in cell therapy. This book describes the many recent developments that have revealed completely different roles of distinct stem cells within the same organ. Stem Cells Heterogeneity in Different Organs provides a timely update on the current information on stem cells heterogeneity in various tissues. It also provides a solid foundation of the history of stem cells from specific tissues and the current applications of this knowledge in regenerative medicine. Taken with its companion volumes, Stem Cells Heterogeneity: Novel Concepts and Stem Cells Heterogeneity in Cancer, this book is essential reading for advanced cell biology students as well as researchers and clinicians working with stem cells.
Author : Kursad Turksen
Publisher : Humana
Page : 0 pages
File Size : 25,25 MB
Release : 2016-08-27
Category : Science
ISBN : 9781493965496
Given the variety of studies and data that have suggested the existence of heterogeneous populations or subpopulations of stem cells, this detailed volume examines different aspects of stem cell heterogeneity. This goes against the long-held tenet that stem cells, defined by their capacity for self-renewal and lineage development, comprised a homogenous population, thus providing the reader with a new avenue of exploration into the complex world of stem cell study. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell Heterogeneity: Methods and Protocols serves as an ideal guide for investigators exploring this important area of research.
Author : Kursad Turksen
Publisher :
Page : 390 pages
File Size : 30,75 MB
Release : 2016
Category : Cytology
ISBN : 9781493965502
Given the variety of studies and data that have suggested the existence of heterogeneous populations or subpopulations of stem cells, this detailed volume examines different aspects of stem cell heterogeneity. This goes against the long-held tenet that stem cells, defined by their capacity for self-renewal and lineage development, comprised a homogenous population, thus providing the reader with a new avenue of exploration into the complex world of stem cell study. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Authoritative and practical, Stem Cell Heterogeneity: Methods and Protocols serves as an ideal guide for investigators exploring this important area of research.
Author : Carlos Simón
Publisher : Cambridge University Press
Page : 199 pages
File Size : 35,14 MB
Release : 2013-07-04
Category : Medical
ISBN : 1107034477
Stem cell science has the potential to impact human reproductive medicine significantly - cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field.
Author : Christina Philippeos
Publisher :
Page : pages
File Size : 22,96 MB
Release : 2017
Category :
ISBN :
The Human Cell Atlas is an international initiative aiming at creating a comprehensive map of all cells in the human body. This project contributes to the Skin Atlas by attempting to resolve a population of interfollicular epidermal stem cells (IFE SCs), previously described as homogeneous. These cells are located in the basal layer of the epidermis, which is distinguished by high expression of a6-integrin. We used this marker to enrich keratinocytes from human skin for basal cells and perform single-cell RNA sequencing.We found three transcriptionally distinct populations of basal keratinocytes. Two of them expressed classic basal layer markers KRT5, KRT14. The differences between these stem cells were driven by genes associated with immunomodulatory function (CCL2, CXCL14, POSTN). The third population of basal keratinocytes was enriched in markers of early stem cell commitment (KRT10, DMKN). The three groups formed a continuous trajectory after pseudotime reconstruction, reflecting differentiation of IFE SCs.We used the same approach to address changes that IFE SCs undergo in psoriasis, an auto-immune disease characterized by skin inflammation and keratinocyte hyperproliferation. We found that basal cells from psoriatic epidermis also have two stem cell sub-populations and one group with the early differentiated signature. The latter was expanded from 8% in healthy skin to 33% in psoriasis. We were also able to identify sub-populations of stem cells that are specific to healthy and disease skin and found non-linear pseudotime trajectory of basal cells in psoriasis, suggesting a stem cell state switch in disease. In conclusion, the Skin Atlas is founding new insights in the epidermal stem cell compartment in healthy and diseased skin.