Jacked (2015-) #1


Book Description

Eric Kripke (creator of Supernatural) teams up with Vertigo veterans John Higgins (HELLBLAZER) and Glenn Fabry (PREACHER) to bring you a very Vertigo take on the modern superhero in this six-issue miniseries. Josh Jaffe, a neurotic family man mid-midlife crisis, buys an online "smart pill" to increase his focus and jolt him out of his slump. But to Josh's surprise, the pill gives him incredible strength and power-but its cost is that it's extremely addictive. This irreverent and brutally realistic story examines both the mighty highs and humiliating lows of being a real-life superhero.




Potential Therapeutic Strategies for Muscular Dystrophy


Book Description

The book provides a comprehensive overview of the different forms of muscular dystrophy (MD), including potential therapeutic interventions and the advantages associated with repurposing pharmaceuticals for treating these conditions. In addition, the book examines the effects of physical training on improving symptoms as well as patient quality of life and life span. The target audience of this book comprises students, researchers, and doctors with an interest in the field of muscular dystrophy.




Jacked


Book Description

As far as Zane knows, today is just another boring day at his boring gas-station job. Until he gets carjacked by a masked gunman. Zane has no idea where they're going or what will happen when they get there. All he knows is that the lunatic in the passenger seat has a gun aimed at him. Zane tries to reason with the guy, and when that fails, he tries a couple of daring stunts to get free, but they backfire. They've been on the road for a long time before Zane's fear starts to ease just a little, enough for his curiosity to take over. His captor has had several opportunities to hurt him or punish him for trying to get away, but he hasn't. Zane starts to wonder who this guy is. And what he really wants.




Muscular Dystrophy


Book Description

Muscular Dystrophy - Research Update and Therapeutic Strategies is for students, researchers, and clinicians interested in muscular dystrophies who want to improve their knowledge of these complex genetic diseases. The book includes information about the genetics of various types of muscular dystrophies as well as explores new and current therapeutic strategies that aim to ameliorate symptoms and improve patients’ quality of life and life expectancy. In addition, this book reviews information on current clinical trials for muscular dystrophies and presents a framework for what to consider during the design of these trials.




Campbell's Physical Therapy for Children Expert Consult - E-Book


Book Description

**Selected for Doody's Core Titles® 2024 with "Essential Purchase" designation in Physical Therapy** Gain a solid foundation in physical therapy for infants, children, and adolescents! Campbell's Physical Therapy for Children, 6th Edition provides essential information on pediatric physical therapy practice, management of children with musculoskeletal, neurological, and cardiopulmonary conditions, and special practice settings. Following the APTA's Guide to Physical Therapist Practice, this text describes how to examine and evaluate children, select evidence-based interventions, and measure outcomes to help children improve their body functions, activities, and participation. What also sets this book apart is its emphasis on clinical reasoning, decision making, and family-centered care. Written by a team of PT experts led by Robert J. Palisano, this book is ideal for use by students and by clinicians in daily practice. - Comprehensive coverage provides a thorough understanding of foundational knowledge for pediatric physical therapy, including social determinants of health, development, motor control, and motor learning, as well as physical therapy management of pediatric disorders, including examination, evaluation, goal setting, the plan of care, and outcomes evaluation. - Focus on the elements of patient/client management in the APTA's Guide to Physical Therapist Practice provides a framework for clinical decision making. - Focus on the International Classification of Functioning, Disability, and Health (ICF) of the World Health Organization (WHO) provides a standard language and framework for the description of health and health-related states, including levels of a person's capacity and performance. - Experienced, expert contributors help you prepare to become a Board-Certified Pediatric Clinical Specialist and to succeed on the job. - NEW! New chapter on social determinants of health and pediatric healthcare is added to this edition. - NEW! New chapter on Down syndrome is added. - NEW! 45 case scenarios in the ebook offer practice with clinical reasoning and decision making, and 123 video clips depict children's movements, examination procedures, and physical therapy interventions. - NEW! An ebook version is included with print purchase, providing access to all the text, figures, and references, plus the ability to search, customize content, make notes and highlights, and have content read aloud.




Characterization and Clinical Management of Dilated Cardiomyopathy


Book Description

Dilated cardiomyopathy (DCM) is a particular phenotype of non-ischemic systolic heart failure, frequently recognizing a genetic background and affecting relatively young patients with few comorbidities. Nowadays, long-term survival of DCM patients has been markedly improved due to an early diagnosis and uninterrupted and tailored follow-up under constant optimal medical and non-pharmacological evidence-based treatments. Nevertheless, DCM is still one of the most common causes of heart transplantation in the western world. Clinical management requires an integrated and systematic use of diagnostic tools and a deeper investigation of the basic mechanisms underlying the disease. However, several emerging issues remain debated. Specifically, the genotype–phenotype correlation, the role of advanced imaging techniques and genetic testing, the lack of appropriate risk stratification models, the need for a multiparametric and multidisciplinary approach for device implantation, and a continuous reclassification of the disease during follow-up remain challenging issues in clinical practice. Therefore, the aim of this Special Issue is to shed the light on the most recent advancements in characterization and clinical management of DCM in order to unveil the conundrum of this particular disease.







Spinal Muscular Atrophy


Book Description

Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases. - Provides comprehensive, up-to-date reviews by leading investigators on diverse topics of SMA, including clinical features and patient care, SMN genetics and protein functions, animal models, disease pathology and mechanisms, biomarkers, current therapeutic development, and the role of non-profit organizations in therapeutic development - Written to bridge multiple disciplines and promote better communications among basic scientists, clinical researchers, and health care providers on the latest developments in SMA - Includes outstanding questions and perspectives for future investigations and key references for additional detailed study







Background and Management of Muscular Atrophy


Book Description

A healthy skeletal musculature is necessary for a good quality of life and is important in sports. The loss of skeletal muscle mass leads to severe clinical complications and alters daily functioning. The aim of this book is to give an overview of skeletal muscle atrophy including pathomechanism, clinical characters, and the tools for prevention and treatment. Skeletal muscle atrophy can develop due to neurogenic or myogenic reasons, and frequently appears as an age-dependent disorder (sarcopenia). The studies of theoretical background give promising perspectives to prevent and treat muscle atrophy. The book is recommended to scientists, practitioners, students, sportsmen, and everybody who is interested in the normal and impaired function of the skeletal muscle.