Jacked (2015-) #1


Book Description

Eric Kripke (creator of Supernatural) teams up with Vertigo veterans John Higgins (HELLBLAZER) and Glenn Fabry (PREACHER) to bring you a very Vertigo take on the modern superhero in this six-issue miniseries. Josh Jaffe, a neurotic family man mid-midlife crisis, buys an online "smart pill" to increase his focus and jolt him out of his slump. But to Josh's surprise, the pill gives him incredible strength and power-but its cost is that it's extremely addictive. This irreverent and brutally realistic story examines both the mighty highs and humiliating lows of being a real-life superhero.




Jacked Vol. 1


Book Description

Eric Kripke (creator of the hit TV series SUPERNATURAL) teams up with Vertigo veterans John Higgins (HELLBLAZER) and Glenn Fabry (PREACHER) to bring you a very Vertigo take on the modern superhero in this new graphic novel thriller. Josh Jaffe, a neurotic family man mid-midlife crisis, purchase a "smart pill" to increase his focus and jolt him out of his slump. But to Josh's surprise, the pill gives him incredible strength and power-at the cost of being extremely addictive. This irreverent and brutally realistic story examines both the mighty highs and humiliating lows of being a real-life superhero. Collects JACKED #1-6.




Background and Management of Muscular Atrophy


Book Description

A healthy skeletal musculature is necessary for a good quality of life and is important in sports. The loss of skeletal muscle mass leads to severe clinical complications and alters daily functioning. The aim of this book is to give an overview of skeletal muscle atrophy including pathomechanism, clinical characters, and the tools for prevention and treatment. Skeletal muscle atrophy can develop due to neurogenic or myogenic reasons, and frequently appears as an age-dependent disorder (sarcopenia). The studies of theoretical background give promising perspectives to prevent and treat muscle atrophy. The book is recommended to scientists, practitioners, students, sportsmen, and everybody who is interested in the normal and impaired function of the skeletal muscle.




Potential Therapeutic Strategies for Muscular Dystrophy


Book Description

The book provides a comprehensive overview of the different forms of muscular dystrophy (MD), including potential therapeutic interventions and the advantages associated with repurposing pharmaceuticals for treating these conditions. In addition, the book examines the effects of physical training on improving symptoms as well as patient quality of life and life span. The target audience of this book comprises students, researchers, and doctors with an interest in the field of muscular dystrophy.




Muscular Dystrophy


Book Description

Muscular Dystrophy - Research Update and Therapeutic Strategies is for students, researchers, and clinicians interested in muscular dystrophies who want to improve their knowledge of these complex genetic diseases. The book includes information about the genetics of various types of muscular dystrophies as well as explores new and current therapeutic strategies that aim to ameliorate symptoms and improve patients’ quality of life and life expectancy. In addition, this book reviews information on current clinical trials for muscular dystrophies and presents a framework for what to consider during the design of these trials.




Jacked


Book Description

As far as Zane knows, today is just another boring day at his boring gas-station job. Until he gets carjacked by a masked gunman. Zane has no idea where they're going or what will happen when they get there. All he knows is that the lunatic in the passenger seat has a gun aimed at him. Zane tries to reason with the guy, and when that fails, he tries a couple of daring stunts to get free, but they backfire. They've been on the road for a long time before Zane's fear starts to ease just a little, enough for his curiosity to take over. His captor has had several opportunities to hurt him or punish him for trying to get away, but he hasn't. Zane starts to wonder who this guy is. And what he really wants.




Jacked


Book Description

Inside the making of a videogame that defined a generation: Grand Theft Auto Grand Theft Auto is one of the biggest and most controversial videogame franchises of all time. Since its first release in 1997, GTA has pioneered the use of everything from 3D graphics to the voices of top Hollywood actors and repeatedly transformed the world of gaming. Despite its incredible innovations in the $75 billion game industry, it has also been a lightning rod of debate, spawning accusations of ethnic and sexual discrimination, glamorizing violence, and inciting real-life crimes. Jacked tells the turbulent and mostly unknown story of GTA's wildly ambitious creators, Rockstar Games, the invention and evolution of the franchise, and the cultural and political backlash it has provoked. Explains how British prep school brothers Sam and Dan Houser took their dream of fame, fortune, and the glamor of American pop culture and transformed it into a worldwide videogame blockbuster Written by David Kushner, author of Masters of Doom and a top journalist on gaming, and drawn from over ten years of interviews and research, including firsthand knowledge of Grand Theft Auto's creators and detractors Offers inside details on key episodes in the development of the series, including the financial turmoil of Rockstar games, the infamous "Hot Coffee" sex mini-game incident, and more Whether you love Grand Theft Auto or hate it, or just want to understand the defining entertainment product of a generation, you'll want to read Jacked and get the real story behind this boundary-pushing game.




Neuromuscular Disorders


Book Description

This book provides a concise overview of the diagnosis and therapy of a wide variety of neuromuscular disorders, in tabulated form and with illustrative cases. Treating neuromuscular disorders calls for a sound, step-by-step clinical approach based on differential diagnosis and laboratory investigations. Yet to date, there has been no single, compact book that offers all the relevant information related to the management of these disorders. This book fills that gap, presenting the state of the art in the field and addressing practical problems together with their solutions. Each chapter covers disorder characteristics, clinical differentiating points, relevant investigations and their interpretation, available genetic testing, best management approaches and counselling. Illustrative cases provide valuable insights, while extensive tables and illustrations mean that information can be rapidly found.




Pediatric Neurology


Book Description

“This book is highly recommended for those who will engage with pediatric patients as an excellent starting point to learning most clinically relevant management." ---Doody's Review Service, 3 stars Comprehensive and accessible, Pediatric Neurology is the first reference designed for trainees and nonspecialists in search of targeted information on the diagnosis and management of neurologic conditions in children. Providing a broad window on the primary disorders seen in childhood, this book interweaves the expertise of field leaders from top national institutions to concisely distill the foundations of clinical pediatric neurology. Complete with up-to-date disease guidelines and evidence-based treatment recommendations, this book serves as a starting point for physicians and other health professionals who wish to delve into fundamentals of current pediatric neurology practice. Beginning with an overview of the clinical assessment of infants and children, the book features dedicated chapters to all major disorders and conditions likely to be encountered in the pediatric population. Chapters include current information on epidemiology, clinical manifestations, diagnosis, and approaches to management for each condition in addition to tables summarizing key takeaways and detailed illustrations. Using plain language and a clear presentation of information throughout, the book is packed with the clinical wisdom needed for tackling such a complex field. With special emphasis on essential patient care concepts, Pediatric Neurology is the trusted resource for residents, general neurologists, pediatricians, medical students, and other practitioners who care for children and adolescents with neurological disease. Key Features: Introduces the foundations of clinical pediatric neurology Multi-purpose resource for point-of-care use, clinical rotations, or board preparation Organized by disease category to enhance accessibility and retrieval of key information Features chapters written by leading educators and clinicians in the field Incorporates up-to-date disease guidelines, latest FDA-approved drugs, and evidence-based treatment recommendations Purchase includes digital access for use on most mobile devices or computers




Pathologic Conditions of the Human Nervous and Muscular Systems Associated with Mutant Chaperones: Molecular and Mechanistic Aspects


Book Description

This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.