Likelihood, Bayesian, and MCMC Methods in Quantitative Genetics


Book Description

This book, suitable for numerate biologists and for applied statisticians, provides the foundations of likelihood, Bayesian and MCMC methods in the context of genetic analysis of quantitative traits. Although a number of excellent texts in these areas have become available in recent years, the basic ideas and tools are typically described in a technically demanding style and contain much more detail than necessary. Here, an effort has been made to relate biological to statistical parameters throughout, and the book includes extensive examples that illustrate the developing argument.




Quantitative Genetics in the Wild


Book Description

Although the field of quantitative genetics - the study of the genetic basis of variation in quantitative characteristics such as body size, or reproductive success - is almost 100 years old, its application to the study of evolutionary processes in wild populations has expanded greatly over the last few decades. During this time, the use of 'wild quantitative genetics' has provided insights into a range of important questions in evolutionary ecology, ranging from studies conducting research in well-established fields such as life-history theory, behavioural ecology and sexual selection, to others addressing relatively new issues such as populations' responses to climate change or the process of senescence in natural environments. Across these fields, there is increasing appreciation of the need to quantify the genetic - rather than just the phenotypic - basis and diversity of key traits, the genetic basis of the associations between traits, and the interaction between these genetic effects and the environment. This research activity has been fuelled by methodological advances in both molecular genetics and statistics, as well as by exciting results emerging from laboratory studies of evolutionary quantitative genetics, and the increasing availability of suitable long-term datasets collected in natural populations, especially in animals. Quantitative Genetics in the Wild is the first book to synthesize the current level of knowledge in this exciting and rapidly-expanding area. This comprehensive volume also offers exciting perspectives for future studies in emerging areas, including the application of quantitative genetics to plants or arthropods, unraveling the molecular basis of variation in quantitative traits, or estimating non-additive genetic variance. Since this book deals with many fundamental questions in evolutionary ecology, it should be of interest to graduate, post-graduate students, and academics from a wide array of fields such as animal behaviour, ecology, evolution, and genetics.




Genetic Data Analysis for Plant and Animal Breeding


Book Description

This book fills the gap between textbooks of quantitative genetic theory, and software manuals that provide details on analytical methods but little context or perspective on which methods may be most appropriate for a particular application. Accordingly this book is composed of two sections. The first section (Chapters 1 to 8) covers topics of classical phenotypic data analysis for prediction of breeding values in animal and plant breeding programs. In the second section (Chapters 9 to 13) we provide the concept and overall review of available tools for using DNA markers for predictions of genetic merits in breeding populations. With advances in DNA sequencing technologies, genomic data, especially single nucleotide polymorphism (SNP) markers, have become available for animal and plant breeding programs in recent years. Analysis of DNA markers for prediction of genetic merit is a relatively new and active research area. The algorithms and software to implement these algorithms are changing rapidly. This section represents state-of-the-art knowledge on the tools and technologies available for genetic analysis of plants and animals. However, readers should be aware that the methods or statistical packages covered here may not be available or they might be out of date in a few years. Ultimately the book is intended for professional breeders interested in utilizing these tools and approaches in their breeding programs. Lastly, we anticipate the usage of this volume for advanced level graduate courses in agricultural and breeding courses.




Animal Breeding and Genetics


Book Description

This newly updated and revised volume of the Encyclopedia of Sustainability Science and Technology (ESST) details the role of Animal Breeding and Genetics in the sustainability of animal agriculture. The volume covers scientific principles and applications includes the current science used to advance cattle, poultry, swine,sheep, and equine populations, as well as the future role of techniques such as gene editing. International leaders in the field explain foundational concepts such as heritability, the covariance between relatives, statistical approaches to predicting the genetic merit of individuals, and the development and advancement of molecular techniques to elucidate changes in the DNA sequence that underly phenotypic variation. The use of genetic-based tools to improve animal agriculture and meet consumer demands across species is treated in detail. Readers will gain an understanding of how global livestock producers have implemented advanced genetic selection tools and used them to improve reproduction, production, efficiency, health, and sustainability. The interactions of genetics and production environments, and the genetic components of the complex interactions among animals are also discussed. The future of Animal Breeding and Genetics, including the challenges and opportunities that exist in feeding a growing world population, are addressed.




Quantitative Genetics


Book Description

An up-to-date, accessible guide to the main concepts and applications of quantitative genetics.




Statistical Genetics


Book Description

Statistical Genetics is an advanced textbook focusing on conducting genome-wide linkage and association analysis in order to identify the genes responsible for complex behaviors and diseases. Starting with an introductory section on statistics and quantitative genetics, it covers both established and new methodologies, providing the genetic and statistical theory on which they are based. Each chapter is written by leading researchers, who give the reader the benefit of their experience with worked examples, study design, and sources of error. The text can be used in conjunction with an associated website (www.genemapping.org) that provides supplementary material and links to downloadable software.




Hydraulic and Civil Engineering Technology VI


Book Description

New technologies, such as improved testing and physical modeling methods, together with numerical studies and other novel techniques, have led to many developments in the fields of hydraulic and civil engineering in recent years. This book presents proceedings from HCET 2021, the 6th International Technical Conference on Frontiers of Hydraulic and Civil Engineering Technology, held in Sanya, China, on 28 and 29 August 2021. The conference highlighted the latest advances, innovations and applications in the fields of hydraulic and civil engineering, and served as a platform to promote and celebrate interdisciplinary study. The book contains 89 papers, selected from 178 contributions and divided into 4 sections: Modern Civil Engineering; Water and Hydraulic Engineering; Environment Engineering and Sciences; and Transdisciplinary Engineering and Technology. Topics covered involve both theoretical and practical knowledge and understanding, primarily in the areas of hydraulics and water resource engineering, civil engineering, environmental engineering and sciences, transportation engineering, coastal and ocean engineering and transdisciplinary engineering and technology. The book, which presents a wealth of exciting ideas that will open novel research directions and foster multidisciplinary collaboration among specialists in various fields, will be of interest to all academics, researchers, practitioners and policymakers seeking to understand and tackle civil and hydraulic engineering challenges by adopting appropriate, sustainable, solutions.




An Introduction to Bayesian Analysis


Book Description

This is a graduate-level textbook on Bayesian analysis blending modern Bayesian theory, methods, and applications. Starting from basic statistics, undergraduate calculus and linear algebra, ideas of both subjective and objective Bayesian analysis are developed to a level where real-life data can be analyzed using the current techniques of statistical computing. Advances in both low-dimensional and high-dimensional problems are covered, as well as important topics such as empirical Bayes and hierarchical Bayes methods and Markov chain Monte Carlo (MCMC) techniques. Many topics are at the cutting edge of statistical research. Solutions to common inference problems appear throughout the text along with discussion of what prior to choose. There is a discussion of elicitation of a subjective prior as well as the motivation, applicability, and limitations of objective priors. By way of important applications the book presents microarrays, nonparametric regression via wavelets as well as DMA mixtures of normals, and spatial analysis with illustrations using simulated and real data. Theoretical topics at the cutting edge include high-dimensional model selection and Intrinsic Bayes Factors, which the authors have successfully applied to geological mapping. The style is informal but clear. Asymptotics is used to supplement simulation or understand some aspects of the posterior.




Computational Methods for Genetics of Complex Traits


Book Description

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics reasearch. This thematic volume of Advances in Genetics looks at Computational Methods for Genetics of Complex traits. - Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models - Includes methods for testing with ethical, legal, and social implications - Critically analyzes future prospects




Principles of Statistical Genomics


Book Description

Statistical genomics is a rapidly developing field, with more and more people involved in this area. However, a lack of synthetic reference books and textbooks in statistical genomics has become a major hurdle on the development of the field. Although many books have been published recently in bioinformatics, most of them emphasize DNA sequence analysis under a deterministic approach. Principles of Statistical Genomics synthesizes the state-of-the-art statistical methodologies (stochastic approaches) applied to genome study. It facilitates understanding of the statistical models and methods behind the major bioinformatics software packages, which will help researchers choose the optimal algorithm to analyze their data and better interpret the results of their analyses. Understanding existing statistical models and algorithms assists researchers to develop improved statistical methods to extract maximum information from their data. Resourceful and easy to use, Principles of Statistical Genomics is a comprehensive reference for researchers and graduate students studying statistical genomics.




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