Analysis of Human Genetic Linkage


Book Description

Introduction and basic genetic principles; Genetic loci genetic polymorphisms; Aspects of statistical inference; Basics of linkage analysis; The informativeness of family data; Multipoint linkage analysis; Penetrance; Quantitative phenotypes; Numerical and computerized methods; Variability of the recombination fraction; Inconsistencies; Linkage analysis with mendelian disease loci; Nonparametric methods; Two-locus inheritance; Complex traits.




Linkage Papers


Book Description







Geometric Design of Linkages


Book Description

This book is an introduction to the mathematical theory of design for articulated mechanical systems known as linkages. The focus is on sizing mechanical constraints that guide the movement of a work piece, or end-effector, of the system. The function of the device is prescribed as a set of positions to be reachable by the end-effector; and the mechanical constraints are formed by joints that limit relative movement. The goal is to find all the devices that can achieve a specific task. Formulated in this way the design problem is purely geometric in character. Robot manipulators, walking machines, and mechanical hands are examples of articulated mechanical systems that rely on simple mechanical constraints to provide a complex workspace for the end- effector. The principles presented in this book form the foundation for a design theory for these devices. The emphasis, however, is on articulated systems with fewer degrees of freedom than that of the typical robotic system, and therefore, less complexity. This book will be useful to mathematics, engineering and computer science departments teaching courses on mathematical modeling of robotics and other articulated mechanical systems. This new edition includes research results of the past decade on the synthesis of multi loop planar and spherical linkages, and the use of homotopy methods and Clifford algebras in the synthesis of spatial serial chains. One new chapter on the synthesis of spatial serial chains introduces numerical homotopy and the linear product decomposition of polynomial systems. The second new chapter introduces the Clifford algebra formulation of the kinematics equations of serial chain robots. Examples are use throughout to demonstrate the theory.




Linkage Power Europe


Book Description

This book looks at the history of the EU’s trade negotiations with China from 1975 to 2019 from a distinctive perspective – the EU as a linkage power. The author explains how the EU through linkage strategies speaks with one voice, overcomes its weakness in military capabilities and translates its non-military capabilities into advantages and influences in some specific policy areas. The book systematically traces the European negotiators’ tactics in managing the EU’s trade relations with China. It’s the first time that the history of EU–China trade negotiations is presented to the public by a seasoned trade negotiator. The author, combining the identities of a negotiator and a scholar, gives a panoramic view of EU–China trade relations from 1975, when the European Economic Community established diplomatic relations with China, to 2019 when the Juncker Commission leaves office. This book will appeal to policymakers, think-tankers, professors and students, as well as anyone who is interested in trade policies and negotiations in the EU and China. The Open Access version of this book, available at www.taylorfrancis .com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.




Geometric Design of Linkages


Book Description

An introduction to the mathematical theory of design for articulated mechanical systems known as linkages. This book will be useful to mathematics, engineering and computer science departments that teach courses on mathematical modelling of robotics and other articulated mechanical systems.




Kinematic Differential Geometry and Saddle Synthesis of Linkages


Book Description

With a pioneering methodology, the book covers the fundamental aspects of kinematic analysis and synthesis of linkage, and provides a theoretical foundation for engineers and researchers in mechanisms design. • The first book to propose a complete curvature theory for planar, spherical and spatial motion • Treatment of the synthesis of linkages with a novel approach • Well-structured format with chapters introducing clearly distinguishable concepts following in a logical sequence dealing with planar, spherical and spatial motion • Presents a pioneering methodology by a recognized expert in the field and brought up to date with the latest research and findings • Fundamental theory and application examples are supplied fully illustrated throughout




Socio-Economic Linkages Of Industries: A Case Study Of Uranium Industry In East Sinhgbhum District Of Jharkhand


Book Description

Uranium industry occupies a very important place in the socio-economic sphere of East Singhbhum District of Jharkhand ever since its inception in 1967 it has played an important role in influencing health, education, crime, employment, income, migration & displacement and environment of the people of surrounding area. The industry has situated at Jaduguda, which falls under Mushabani and Potka Block of East Singhbhum District of Jharkhand. The socio-economic life of the people residing in and around this area has influenced by this in Jaduguda. The findings are based on a comparison of data on variables like health, education, crime, employment, income, migration & displacement and environment prior to inception of the mines and the situation at present time. It has observed that there has been positive impact on education employment and income. However, the study also observed there are certain negative linkages also. The important one is being deterioration of the health of the people, environmental degradation, and increasing rate of crime, migration & displacement. This study provides a means of identifying and tracking indicators associated with community vitality in Jaduguda communities that relate to the uranium mining industry including approaches that assess community health (physical, mental/emotional, spiritual/cultural, and social), community quality of life, community sustainable development, and community wellness as such, it has undertaken a broad array of studies since its inception, guided by input from community members from Jaduguda. As such, the purpose of the study is to identify the socio-economic linkages both beneficial and otherwise that the modern uranium mining industry has had on Jaduguda, and its residents and communities.




Data Quality and Record Linkage Techniques


Book Description

This book offers a practical understanding of issues involved in improving data quality through editing, imputation, and record linkage. The first part of the book deals with methods and models, focusing on the Fellegi-Holt edit-imputation model, the Little-Rubin multiple-imputation scheme, and the Fellegi-Sunter record linkage model. The second part presents case studies in which these techniques are applied in a variety of areas, including mortgage guarantee insurance, medical, biomedical, highway safety, and social insurance as well as the construction of list frames and administrative lists. This book offers a mixture of practical advice, mathematical rigor, management insight and philosophy.




Design of Special Planar Linkages


Book Description

Planar linkages play a very important role in mechanical engineering. As the simplest closed chain mechanisms, planar four-bar linkages are widely used in mechanical engineering, civil engineering and aerospace engineering. Design of Special Planar Linkages proposes a uniform design theory for planar four-bar linkages. The merit of the method proposed in this book is that it allows engineers to directly obtain accurate results when there are such solutions for the specified n precise positions; otherwise, the best approximate solutions will be found. This book discusses the kinematics and reachable workspace and singularity of a planar 3-RRR linkage, which can be used to analyze other planar linkages. Then a foldable stair that retains the walking conversions of human beings and all the merits of a concrete stair in civil engineering is described along with a lifting guidance mechanism that has the advantages of high strength, high rigidity, lightweight overconstraint trusses and motion flexibility. The method proposed in this book can be applied to other planar linkages. This book offers a valuable resource for scientists, researchers, engineers, graduate students in mechanical engineering especially those interested in engineering design, robotics and automation. Jingshan Zhao, Associate professor; Zhijing Feng and Fulei Chu, professor; Ning Ma, Dr., all work at the Department of Mechanical Engineering, Tsinghua University.