Metabolic Interconversion of Enzymes 1980


Book Description

Previous symposia on Metabolic Interconversion of Enzymes were held in 1970 (Santa Margherita-Ligure, Italy), 1971 (Rottach-Egern, Ger­ many), 1973 (Seattle, USA) and 1975 (Arad, Israel). The present pub­ lication reports the proceedings of the 5th International Symposium on Metabolic Interconversion of Enzymes, held in Titisee/Black Forest (Germany) from October 1st-5th, 1980. In the last few years, the number of enzymes for which control of activity by enzyme-catalyzed covalent modification, i.e., by intercon­ version, is of recognized metabolic importance has increased so much that is was not possible to have every such enzyme considered during a 3-day conference. The organizers therefore decided to devote only one of the three sections to "metabolic interconversion" per se, and to cover in the other two sections "enzyme regulation by proteolytic modification" and "novel aspects of regulation". According to the IUP AC-IUB Commission on Biochemical Nomenclature (cf. J. Biol. Chem. 252,5939-5941 (1977)), modification by proteolysis is not in­ cluded in "metabolic interconversion". Considering, however, the close interrelationship of these two types of enzyme control, it has become a tradition, beginning with the conference in Rottach-Egern 1971, to include proteolytic modification in our conferences.







Current Topics in Cellular Regulation


Book Description

Current Topics in Cellular Regulation, Volume 11 focuses on the biochemical mechanisms and key role of the liver in the homeostasis of blood glucose. This book begins with a discussion of glucokinase that is known to play a key role in glucose uptake by liver, followed by a broad overview of the mechanisms that control both glucose uptake by and release from the liver and enzymes involved in glycogen synthesis and breakdown. The classical enzyme models for allosteric regulatory mechanisms known as the biodegradative threonine deaminase are also elaborated. Other topics include the control of blood cholesterol levels, use of cultured mammalian cells, and studies of mutant cell lines. A model for protein turnover is likewise presented, including other mechanisms for the selective degradation of protein, selective uptake by lysosomes, and possible role of stabilizing factors. This publication concludes with an evaluation of complex regulatory mechanisms proposed for the regulation of photosynthetic carbon assimilation. This volume is recommended for biologists and researchers interested in advances in the general area of cellular regulation.




Environmental Regulation of Microbial Metabolism


Book Description

Environmental Regulation of Microbial Metabolism contains the proceedings of the Federation of European Microbiological Societies Symposium held in Pushchino, USSR, on June 1-7, 1983. The symposium provided a forum for reviewing the environmental regulation of the metabolism of autotrophic and heterotrophic microorganisms; regulation of the biogenesis of cell walls and other structures in prokaryotic and eukaryotic microorganisms; and regulation of the secretion of macromolecules and transport of ions and solutes across microbial membranes. Comprised of 52 chapters, this book begins with an overview of some aspects of environmental regulation of microbial phosphorus metabolism, followed by a discussion on the role of covalent interconversion of enzymes in the regulation of microbial metabolism. Subsequent chapters explore the role and regulation of inorganic pyrophosphatase in bacteria; the central metabolism of pseudomonads degrading xenobiotics; the role of nickel enzymes in anaerobic metabolism; and the oxidation of aromatic compounds by microalgae. The book also considers carbon metabolism in phototrophic bacteria under different conditions of growth, along with the transport of solutes and metabolites in prokaryotes and eukaryotes. This monograph will be helpful to a wide range of specialists in the fields of biochemistry, physiology, molecular biology, and biotechnology.




The Year in Metabolism 1975–1976


Book Description

It is unclear, and really no longer relevant, whether the information explosion that we now contend with has been fostered by the growth of specialization and subspecialization in medicine, or vice versa. What is clear is that the two are mutually supportive and constitute what would be in endocrine parlance a short-loop positive feedback system. As a result, for most areas of medicine, even the subspecialist in that area has a problem in maintaining currency, the more general specialist has substan tial difficulty in doing so, and the generalist is tempted to abandon the effort altogether. Nevertheless, for all, both the internal pressures of conscience and self-esteem and the external pressures generated by peer review, recertifi cation, and subspecialty boards create the need for continuous self-educa tion. We are, therefore, in an era in which the means of dissemination of new information deserves as much creative attention as does its acquisition.




Biochemical Actions of Hormones V6


Book Description

Biochemical Actions of Hormones, Volume VI is a 10-chapter text that summarizes the regulation of protein kinases and phosphoprotein phosphatases and the relationship of the endocrines to cancer. This volume describes first the precise structures of steroid hormones and carcinogens. The subsequent chapters cover the hormonal regulation of chemical carcinogenesis; the importance of steroid hormones as growth factors for mammary tumors; the effects of steroid hormones in the central nervous system; and the properties of the purified estrogen receptor. A chapter highlights the biochemical actions of neurohypophysial hormones and neurophysin. Another chapter presents the biochemistry and physiology of cytokinin, a plant hormone. The final chapter exemplifies the multihormonal systems by control of the a2u-globulin produced in the liver. This book will be of great value to endocrinologists.




Regulation Of Carbohydrate Metabolism


Book Description

This text comprises of two volumes discussing the regulation of carbohydrate metabolism.




Biological Regulation and Development


Book Description

The motivation for us to conceive this work on regulation was mainly our belief that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We thought it might be interesting and instructive-for both author and reader-to examine a particular area of investigation in a framework of many different problems. Cutting across the traditional boundaries that have separated the sub jects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who are willing to write about areas outside those pursued in their own laborato ries. Anyone who takes on the task of reviewing a broad area of interest must weave together its various parts by picking up the threads from many different laboratories, and attempt to produce a fabric with a meaningful design. Finding persons who are likely to succeed in such tasks was the most difficult part of our job. In the first volume of this treatise, most of the chapters dealt with the mechanisms of regulation of gene expression in microorganisms. This second volume involves a somewhat broader area, spanning the prokaryotic-eukaryotic border.




Current Catalog


Book Description

First multi-year cumulation covers six years: 1965-70.