Author : Valentim R. Alferes
Publisher : SAGE
Page : 209 pages
File Size : 22,42 MB
Release : 2012-10
Category : Psychology
ISBN : 1452202923
This text provides a conceptual systematization and a practical tool for the randomization of between-subjects and within-subjects experimental designs.
Author : William F. Rosenberger
Publisher : John Wiley & Sons
Page : 284 pages
File Size : 21,17 MB
Release : 2015-11-23
Category : Mathematics
ISBN : 1118742249
Praise for the First Edition “All medical statisticians involved in clinical trials should read this book...” - Controlled Clinical Trials Featuring a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. Randomization in Clinical Trials: Theory and Practice, Second Edition features: Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate-adaptive randomization, including minimization techniques and inference New developments in restricted randomization and an increased focus on computation of randomization tests as opposed to the asymptotic theory of randomization tests Plenty of problem sets, theoretical exercises, and short computer simulations using SAS® to facilitate classroom teaching, simplify the mathematics, and ease readers’ understanding Randomization in Clinical Trials: Theory and Practice, Second Edition is an excellent reference for researchers as well as applied statisticians and biostatisticians. The Second Edition is also an ideal textbook for upper-undergraduate and graduate-level courses in biostatistics and applied statistics. William F. Rosenberger, PhD, is University Professor and Chairman of the Department of Statistics at George Mason University. He is a Fellow of the American Statistical Association and the Institute of Mathematical Statistics, and author of over 80 refereed journal articles, as well as The Theory of Response-Adaptive Randomization in Clinical Trials, also published by Wiley. John M. Lachin, ScD, is Research Professor in the Department of Epidemiology and Biostatistics as well as in the Department of Statistics at The George Washington University. A Fellow of the American Statistical Association and the Society for Clinical Trials, Dr. Lachin is actively involved in coordinating center activities for clinical trials of diabetes. He is the author of Biostatistical Methods: The Assessment of Relative Risks, Second Edition, also published by Wiley.
Author : Valentim R. Alferes
Publisher : SAGE Publications
Page : 209 pages
File Size : 25,1 MB
Release : 2012-10-01
Category : Social Science
ISBN : 1483303527
In Methods of Randomization in Experimental Design, author Valentim R. Alferes presents the main procedures of random assignment and local control in between-subjects experimental designs and the counterbalancing schemes in within-subjects or cross-over experimental designs. Alferes uses a pedagogical strategy that allows the reader to implement all randomization methods by relying on the materials given in the appendices and using common features included in most word processor software. A companion website at www.sagepub.com/alferes provides downloadable IBM SPSS and R versions of SCRAED, a package that performs simple and complex random assignment in experimental design, including the 18 randomization methods presented in Chapters 2 and 3.
Author : Anton Bespalov
Publisher : Springer Nature
Page : 424 pages
File Size : 44,7 MB
Release : 2020-01-01
Category : Cardiology
ISBN : 3030336565
This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
Author : Neil J. Salkind
Publisher : SAGE
Page : 1779 pages
File Size : 23,47 MB
Release : 2010-06-22
Category : Philosophy
ISBN : 1412961270
"Comprising more than 500 entries, the Encyclopedia of Research Design explains how to make decisions about research design, undertake research projects in an ethical manner, interpret and draw valid inferences from data, and evaluate experiment design strategies and results. Two additional features carry this encyclopedia far above other works in the field: bibliographic entries devoted to significant articles in the history of research design and reviews of contemporary tools, such as software and statistical procedures, used to analyze results. It covers the spectrum of research design strategies, from material presented in introductory classes to topics necessary in graduate research; it addresses cross- and multidisciplinary research needs, with many examples drawn from the social and behavioral sciences, neurosciences, and biomedical and life sciences; it provides summaries of advantages and disadvantages of often-used strategies; and it uses hundreds of sample tables, figures, and equations based on real-life cases."--Publisher's description.
Author : Institute of Medicine
Publisher : National Academies Press
Page : 221 pages
File Size : 28,31 MB
Release : 2001-01-01
Category : Medical
ISBN : 0309171148
Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Author : J. C. Barnes
Publisher : John Wiley & Sons
Page : 967 pages
File Size : 10,71 MB
Release : 2021-09-08
Category : Social Science
ISBN : 1119110726
The Encyclopedia of RESEARCH METHODS IN CRIMINOLOGY & CRIMINAL JUSTICE The most comprehensive reference work on research designs and methods in criminology and criminal justice This Encyclopedia of Research Methods in Criminology and Criminal Justice offers a comprehensive survey of research methodologies and statistical techniques that are popular in criminology and criminal justice systems across the globe. With contributions from leading scholars and practitioners in the field, it offers a clear insight into the techniques that are currently in use to answer the pressing questions in criminology and criminal justice. The Encyclopedia contains essential information from a diverse pool of authors about research designs grounded in both qualitative and quantitative approaches. It includes information on popular datasets and leading resources of government statistics. In addition, the contributors cover a wide range of topics such as: the most current research on the link between guns and crime, rational choice theory, and the use of technology like geospatial mapping as a crime reduction tool. This invaluable reference work: Offers a comprehensive survey of international research designs, methods, and statistical techniques Includes contributions from leading figures in the field Contains data on criminology and criminal justice from Cambridge to Chicago Presents information on capital punishment, domestic violence, crime science, and much more Helps us to better understand, explain, and prevent crime Written for undergraduate students, graduate students, and researchers, The Encyclopedia of Research Methods in Criminology and Criminal Justice is the first reference work of its kind to offer a comprehensive review of this important topic.
Author : Valentim R. Alferes
Publisher :
Page : 183 pages
File Size : 47,83 MB
Release : 2012
Category : Experimental design
ISBN : 9781452270012
This text provides a conceptual systematization and a practical tool for the randomization of between-subjects and within-subjects experimental designs.
Author : Robert F. Boruch
Publisher : SAGE
Page : 284 pages
File Size : 33,61 MB
Release : 1997
Category : Social Science
ISBN : 9780803935105
Boruch untangles the complexities of randomized field experiments, exploring the criteria for deciding whether a programme has worked or not, standards used to judge the ethcial propriety of the experiments and baseline measures.
Author : Greg Guest
Publisher : SAGE
Page : 833 pages
File Size : 50,26 MB
Release : 2015
Category : Medical
ISBN : 1452241333
Providing a comprehensive foundation for planning, executing, and monitoring public health research of all types, this book goes beyond traditional epidemiologic research designs to cover technology-based approaches emerging in the new public health landscape.
