Modern Inference Based on Health-Related Markers


Book Description

Modern Inference Based on Health Related Markers: Biomarkers and Statistical Decision Making provides a compendium of biomarkers based methodologies for respective health related fields and health related marker-specific biostatistical techniques. These methodologies may be applied to various problems encountered in medical and epidemiological studies. This book introduces correct and efficient testing mechanisms including procedures based on bootstrap and permutation methods with the aim of making these techniques assessable to practical researchers. In the biostatistical aspect, it describes how to correctly state testing problems, but it also includes novel results, which have appeared in current statistical publications. The book discusses also modern applied statistical developments that consider data-driven techniques, including empirical likelihood methods and other simple and efficient methods to derive statistical tools for use in health related studies. The title is a valuable source for biostaticians, practitioners, theoretical and applied investigators, and several members of the biomedical field who are interested in learning more about efficient evidence-based inference incorporating several forms of markers measurements. - Combines modern epidemiological and public health discoveries with cutting-edge biostatistical tools, including relevant software codes, offering one full package to meet the demand of practical investigators - Includes the emerging topics from real health fields in order to display recent advances and trends in Biomarkers and associated Decision Making areas - Written by researchers who are leaders of Epidemiological and Biostatistical fields, presenting up-to-date investigations related to the measuring health issues, emerging fields of biomarkers, designing health studies and their implementations, clinical trials and their practices and applications, different aspects of genetic markers




Artificial Intelligence in Healthcare


Book Description

Artificial Intelligence (AI) in Healthcare is more than a comprehensive introduction to artificial intelligence as a tool in the generation and analysis of healthcare data. The book is split into two sections where the first section describes the current healthcare challenges and the rise of AI in this arena. The ten following chapters are written by specialists in each area, covering the whole healthcare ecosystem. First, the AI applications in drug design and drug development are presented followed by its applications in the field of cancer diagnostics, treatment and medical imaging. Subsequently, the application of AI in medical devices and surgery are covered as well as remote patient monitoring. Finally, the book dives into the topics of security, privacy, information sharing, health insurances and legal aspects of AI in healthcare. - Highlights different data techniques in healthcare data analysis, including machine learning and data mining - Illustrates different applications and challenges across the design, implementation and management of intelligent systems and healthcare data networks - Includes applications and case studies across all areas of AI in healthcare data




Biosocial Surveys


Book Description

Biosocial Surveys analyzes the latest research on the increasing number of multipurpose household surveys that collect biological data along with the more familiar interviewerâ€"respondent information. This book serves as a follow-up to the 2003 volume, Cells and Surveys: Should Biological Measures Be Included in Social Science Research? and asks these questions: What have the social sciences, especially demography, learned from those efforts and the greater interdisciplinary communication that has resulted from them? Which biological or genetic information has proven most useful to researchers? How can better models be developed to help integrate biological and social science information in ways that can broaden scientific understanding? This volume contains a collection of 17 papers by distinguished experts in demography, biology, economics, epidemiology, and survey methodology. It is an invaluable sourcebook for social and behavioral science researchers who are working with biosocial data.




Modern Epidemiology


Book Description

The thoroughly revised and updated Third Edition of the acclaimed Modern Epidemiology reflects both the conceptual development of this evolving science and the increasingly focal role that epidemiology plays in dealing with public health and medical problems. Coauthored by three leading epidemiologists, with sixteen additional contributors, this Third Edition is the most comprehensive and cohesive text on the principles and methods of epidemiologic research. The book covers a broad range of concepts and methods, such as basic measures of disease frequency and associations, study design, field methods, threats to validity, and assessing precision. It also covers advanced topics in data analysis such as Bayesian analysis, bias analysis, and hierarchical regression. Chapters examine specific areas of research such as disease surveillance, ecologic studies, social epidemiology, infectious disease epidemiology, genetic and molecular epidemiology, nutritional epidemiology, environmental epidemiology, reproductive epidemiology, and clinical epidemiology.




Foundations of Evidence-Based Medicine


Book Description

This comprehensive text focuses on reasoning, critical thinking and pragmatic decision making in medicine. Based on the author’s extensive experience and filled with definitions, formulae, flowcharts and checklists, this fully revised second edition continues to provide invaluable guidance to the crucial role that clinical epidemiology plays in the expanding field of evidence-based medicine. Key Features: • Considers evidence-based medicine as a universal initiative common to all health sciences and professions, and all specialties within those disciplines • Demonstrates how effective practice is reliant on proper foundations, such as clinical and fundamental epidemiology, and biostatistics • Introduces the reader to basic epidemiological methods, meta-analysis and decision analysis • Shows that structured, modern, argumentative reasoning is required to build the best possible evidence and use it in practice and research • Outlines how to make the most appropriate decisions in clinical care, disease prevention and health promotion Presenting a range of topics seldom seen in a single resource, the innovative blend of informal logic and structured evidence-based reasoning makes this book invaluable for anyone seeking broad, in-depth and readable coverage of this complex and sometimes controversial field.




Developmental Psychopathology, Theory and Method


Book Description

The seminal reference for the latest research in developmental psychopathology Developmental Psychopathology is a four-volume compendium of the most complete and current research on every aspect of the field. Volume One: Theory and Method focuses on the theoretical and empirical work that has contributed to dramatic advancements in understanding of child and adult development, including findings in the areas of genetics and neurobiology, as well as social and contextual factors. Now in its third edition, this comprehensive reference has been fully updated to reflect the current state of the field and its increasingly multilevel and interdisciplinary nature and the increasing importance of translational research. Contributions from expert researchers and clinicians provide insight into how multiple levels of analysis may influence individual differences, the continuity or discontinuity of patterns, and the pathways by which the same developmental outcomes may be achieved. Advances in developmental psychopathology have burgeoned since the 2006 publication of the second edition ten years ago, and keeping up on the latest findings in multiple avenues of investigation can be burdensome to the busy professional and researcher from psychology and related fields. This reference solves the problem by collecting the best of the best, as edited by Dante Cicchetti, a recognized leader in the field, into one place, with a logical organization designed for easy reference. Get up to date on the latest research from the field Explore new models, emerging theory, and innovative approaches Learn new technical analysis and research design methods Understand the impact of life stage on mental health The complexity of a field as diverse as developmental psychopathology deepens with each emerging theory and new area of study, as made obvious by the exciting findings coming out of institutions and clinics around the world. Developmental Psychopathology Volume One: Theory and Method brings these findings together into a cohesive, broad-reaching reference.







Oral Health Epidemiology


Book Description

As a result of scientific advancements and changing demographics in the United States and around the world, people of all ethnic groups and nationalities are retaining their teeth longer. Todays oral health professionals must therefore be prepared to make educated and scientifically-reasoned choices addressing a wide range of oral diseases for patients of all ages, and for ambulatory as well as non-ambulatory patients across all demographic profiles. As the first text of its kind, Oral Health Epidemiology: Principles and Practice explores the full spectrum of epidemiological and translational clinical research including fundamental mechanisms of human disease, therapeutic intervention, clinical trials, and oral epidemiology. Topics that are unique to oral health, such as the frequent use of split-mouth design on oral research, crossover techniques and clustered nature of caries, periodontal and other dental disease data, are all thoroughly addressed. Key Features: Thoroughly explores clinicaltranslational research and the special needs of oral health study designs that are applicable across all specialties in dentistry. Serves as a basic guide to advanced techniques such as bioinformatics, genetics, molecular biology, and computer simulation, biostatistics that are now used regularly in oral health research. Prepares the reader to design studies, translate the findings to practice, and conduct logical critique of scientific literature.




Oxford Textbook of Global Public Health


Book Description

Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline




Translational Systems Biology


Book Description

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money's worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. - Provides an explicit, reasoned, and systematic approach to dealing with the challenges of translational science across disciplines - Establishes the case for including computational modeling at all stages of biomedical research and healthcare delivery, from early pre-clinical studies to long-term care, by clearly delineating efficiency and costs saving important to business investment - Guides readers on how to communicate across domains and disciplines, particularly between biologists and computational researchers, to effectively develop multi- and trans-disciplinary research teams