› › Nano Strategies For Addressing Antimicrobial Resistance

Nano-Strategies for Addressing Antimicrobial Resistance

Author : Vinay Kumar

Publisher : Springer Nature

Page : 418 pages

File Size : 28,35 MB

Release : 2022-12-18

Category : Science

ISBN : 3031102207

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Book Description

Antibiotics, the backbone of modern clinical-medicine, are facing serious challenges from emerging antimicrobial-resistance (AMR), a complicated phenomenon expanding in bacterial species, from nosocomial to community origins, where microbes are no longer sensitive to a range of commonly used antibiotics. AMR has exploded in recent years and is posing a serious threat to human health and survival. This necessitates novel and effective ways of diagnosis, drug-delivery, and treatment; nanotechnology and advanced nanomaterials are hailed as a potent solution in containing AMR.The main thrust of this volume is to explain the most current research on the central theme of potential use of nano-approaches for diagnosis, detection, drug-delivery and as antimicrobial agents against drug-resistant pathogenic microbes. This book provides an integrated blend of basic and advanced information for students, scholars, scientists and practitioners, interested or already engaged in research in these areas. We have brought together leading international authors to present and highlight various aspects of nanotechnology in combating AMR in WHO-prioritized microbes. Topics range from advances in nanomaterial synthesis, characterization, functionalization and improvisation, as well as applications in sensing, diagnosis of AMR, and their therapeutic and drug-delivery potential against MDR and XDR microbial phenotypes.



Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer

Author : Saravanan, Muthupandian

Publisher : IGI Global

Page : 559 pages

File Size : 22,14 MB

Release : 2021-02-12

Category : Medical

ISBN : 1799850501

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Book Description

Multidrug-resistant bacteria play a significant role in public health by destroying the potency of existing antibiotics. Meanwhile, cancer remains one of the most common health problems that impact society, resulting in many deaths worldwide. Novel strategies are required to combat antimicrobial resistance and create efficient anticancer drugs that could revolutionize treatment. Nanomedicine is one such innovation that plays a significant role in developing alternative and more effective treatment strategies for antimicrobial resistance and cancer theranostics. The Handbook of Research on Nano-Strategies for Combatting Antimicrobial Resistance and Cancer is an essential scholarly resource that examines (1) how to overcome the existing, traditional approaches to combat antimicrobial resistance and cancer; (2) how to apply multiple mechanisms to target the cancer cells and microbes; and (3) how the nanomaterials can be used as carriers. Featuring a range of topics such as bacteriophage, nanomedicine, and oncology, this book is ideal for molecular biologists, microbiologists, nanotechnologists, academicians, chemists, pharmacists, oncologists, researchers, healthcare professionals, and students.





Functionalized Nanomaterials for the Management of Microbial Infection

Author : Rabah Boukherroub

Publisher : William Andrew

Page : 339 pages

File Size : 38,32 MB

Release : 2016-12-14

Category : Science

ISBN : 032341737X

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Book Description

Functionalized Nanomaterials for the Management of Microbial Infection: A Strategy to Address Microbial Drug Resistance introduces the reader to the newly developing use of nanotechnology to combat microbial drug resistance. Excessive use of antibiotics and antimicrobial agents has produced an inexorable rise in antibiotic resistance in bacterial pathogens. The use of nanotechnology is currently the most promising strategy to overcome microbial drug resistance. This book shows how, due to their small size, nanoparticles can surmount existing drug resistance mechanisms, including decreased uptake and increased efflux of the drug from the microbial cell, biofilm formation, and intracellular bacteria. In particular, chapters cover the use of nanoparticles to raise intracellular antimicrobial levels, thus directly targeting sites of infection and packaging multiple antimicrobial agents onto a single nanoparticle. Provides the information users need to integrate antibacterial nanoparticles into future treatments Gives readers with backgrounds in nanotechnology, chemistry, and materials science an understanding of the main issues concerning microbial drug resistance and its challenges Includes real-life case studies that illustrates how functionalized nanomaterials are used to manage microbial infection



Nanostructures for Antimicrobial Therapy

Author : Anton Ficai

Publisher : Elsevier

Page : 724 pages

File Size : 13,40 MB

Release : 2017-05-29

Category : Science

ISBN : 0323461514

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Book Description

Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. Shows how nanoantibiotics can be used to more effectively treat disease Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area



Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance

Author : Muthupandian Saravanan

Publisher : Elsevier

Page : 790 pages

File Size : 10,45 MB

Release : 2022-06-22

Category : Technology & Engineering

ISBN : 0323998100

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Book Description

Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance focuses on recent and emerging trends surrounding nanomaterials and nano-drug delivery approaches to combat antimicrobial resistance. The relationship between nanomaterials and antimicrobial activity needs to be deeply explored to meet the challenges of combating antimicrobial resistance. The content of this book is divided into three main topic areas, including (i) how to overcome the existing traditional approaches to combat antimicrobial resistance, (ii) applying multiple drug delivery mechanisms to target multi-drug resistant microbes, and (iii) how nanomaterials can be used as drug carriers. This is an important reference source for those looking to understand how nanotechnology plays an important role in combatting disease and infection. As antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi, this is a timely resource. Outlines how to overcome existing traditional approaches to combatting antimicrobial resistance Explains how to apply multiple drug delivery mechanisms (MDR) to the target area in order to better combat antimicrobial resistance Shows how nanomaterials are used as drug carriers in this context



Microbial Interactions at Nanobiotechnology Interfaces

Author : R. Navanietha Krishnaraj

Publisher : John Wiley & Sons

Page : 420 pages

File Size : 36,58 MB

Release : 2021-11-02

Category : Technology & Engineering

ISBN : 1119617197

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Book Description

MICROBIAL INTERACTIONS AT NANOBIOTECHNOLOGY INTERFACES This book covers a wide range of topics including synthesis of nanomaterials with specific size, shape, and properties, structure-function relationships, tailoring the surface of nanomaterials for improving the properties, interaction of nanomaterials with proteins/microorganism/eukaryotic cells, and applications in different sectors. This book also provides a strong foundation for researchers who are interested to venture into developing functionalized nanomaterials for any biological applications in their research. Practical concepts such as modelling nanomaterials, and simulating the molecular interactions with biomolecules, transcriptomic or genomic approaches, advanced imaging techniques to investigate the functionalization of nanomaterials/interaction of nanomaterials with biomolecules and microorganisms are some of the chapters that offer significant benefits to the researchers.



Antimicrobial Nanoarchitectonics

Author : Alexandru Mihai Grumezescu

Publisher : William Andrew

Page : 578 pages

File Size : 16,92 MB

Release : 2017-06-22

Category : Science

ISBN : 0323527345

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Book Description

Antimicrobial Nanoarchitectonics: From Synthesis to Applications brings together recent research in antimicrobial nanoparticles, specifically in the sustained and controlled delivery of antimicrobials. Particular attention is given to i) reducing the side effects of antibiotics, ii) increasing the pharmacological effect, and iii) improving aqueous solubility and chemical stability of different antimicrobials. In addition, antimicrobial nanoparticles in drug delivery are discussed extensively. The book also evaluates the pros and cons of using nanostructured biomaterials in the prevention and eradication of infections. It is an important reference resource for materials scientists and bioengineers who want to learn how nanomaterials are used in antimicrobial therapy. Provides readers with the information necessary to select the appropriate bionanomaterial to solve particular infection problems Includes case studies, showing how particular bionanomaterials have been used to cure infections Explains the central role that nanotechnology plays in modern antimicrobial therapy Evaluates the pros and cons of using nanostructured biomaterials in the prevention and eradication of infections



Nanotechnology Tools for Infection Control

Author : Alessandro Poma

Publisher : Elsevier

Page : 414 pages

File Size : 20,83 MB

Release : 2024-08-26

Category : Technology & Engineering

ISBN : 0128239956

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Book Description

Nanotechnology Tools for Infections Control: Scanning New Horizons on Next-Generation Therapies to Eradicate Pathogens and Fight Drug Resistance provides an overview of recent strategies to build nanotechnology platforms, with a specific focus on biocompatible and biodegradable nanosystems. Particular attention is given to responsive nanoparticles, which are able to sense and respond to specific external stimuli (e.g., temperature, pH). The book includes details of the rationale behind the design of the raw materials, synthetic procedures and characterization techniques. It also introduces a new generation of nanomaterials, commonly named as ‘nanobots’, which are able to self-propel in response to external stimuli. Subsequent sections of the book focus on the applications of nanosystems as an alternative approach to standard antibiotics. The chapters describe their pharmokinetic and dynamics within the body, their ability to cross biological barriers and how they distribute within different body compartments. In this respect, a dedicated section highlights the crucial role of the immune system, as well as of protein corona, in changing the nanoparticles retention within the body. Coverage is also given to describe how nanosystems access different cells and their intracellular trafficking. Provides an overview of the current challenges in infection and immunity, showing how nanosystems can be used to meet them Focuses on the translational potential of nanotechnology for both clinical and commercial applications Assesses the major challenges of effectively using nanotechnology in immunology



Nanostructures for Antimicrobial and Antibiofilm Applications

Author : Ram Prasad

Publisher : Springer Nature

Page : 461 pages

File Size : 11,81 MB

Release : 2020-05-12

Category : Science

ISBN : 3030403378

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Book Description

In the pursuit of technological advancement in the field of biotechnology and pharmaceutical industries to counteract health issues, bacterial infections remain a major cause of morbidity and mortality. The ability of bacterial pathogens to form biofilms further agglomerates the situation by showing resistance to conventional antibiotics. To overcome this serious issue, bioactive metabolites and other natural products were exploited to combat bacterial infections and biofilm-related health consequences. Natural products exhibited promising results in vitro, however; their efficacy in in vivo conditions remain obscured due to their low-solubility, bioavailability, and biocompatibility issues. In this scenario, nanotechnological interventions provide a multifaceted platform for targeted delivery of bioactive compounds by slow and sustained release of drug-like compounds. The unique physico-chemical properties, biocompatibility and eco-friendly nature of bioinspired nanostructures has revolutionized the field of biology to eradicate microbial infections and biofilm-related complications. The green-nanotechnology based metal and metal oxide nanoparticles and polymeric nanoparticles have been regularly employed for antimicrobial and antibiofilm applications without causing damage to host tissues. The implications of these nanoparticles toward achieving sustainability in agriculture by providing systemic resistance against a variety of phytopathogens therefore plays crucial role in growth and crop productivity. Also the advent of smart and hybrid nanomaterials such as metal-based polymer nanocomposites, lipid-based nanomaterials and liposomes have the inherent potential to eradicate bacterial biofilm-related infections in an efficient manner. The recent development of carbon-based nanomaterials such as carbon nanotubes (CNTs) and silica based nanomaterials such as mesoporous silica nanoparticles (MSNs) also exploit a target of dreadful healthcare conditions such as cancer, immunomodulatory diseases, and microbial infections, as well as biofilm-related issues owing to their stability profile, biocompatibility, and unique physio-chemical properties. Recently novel physical approaches such as photothermal therapy (PTT) and antimicrobial photodynamic therapy (aPDT) also revolutionized conventional strategies and are engaged in eradicating microbial biofilm-related infections and related health consequences. These promising advancements in the development of novel strategies to treat microbial infections and biofilm-related multidrug resistance (MDR) phenomenon may provide new avenues and aid to conventional antimicrobial therapeutics.