OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 428: Skin Absorption: In Vitro Method


Book Description

This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...




OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method


Book Description

The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...




OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document for the Conduct of Studies of Occupational Exposure to Pesticides During Agricultural Application


Book Description

This Guidance Document presents an internationally harmonized approach to the conduct of studies of occupational exposure to pesticides during agricultural application.













OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation


Book Description

The purpose of this Guidance Document is to apply the principles of the Three Rs to the use of animals in regulatory toxicity tests.




OECD Series on Testing and Assessment Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Skin Corrosion and Irritation


Book Description

This Guidance Document proposes an integrated approach on testing and assessment (IATA) for skin corrosion and irritation. It also provides consistent information on key characteristics of each of the individual information sources of the IATA, and relevant guidance on how to integrate ...




OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Guidance Document for the Development of OECD Guidelines for Testing of Chemicals


Book Description

This Monograph describes in detail the process of Test Guideline development, including the structure of the Test Guidelines Programme, the responsibilities of those involved and the procedures which should be followed.