OECD Guidelines for the Testing of Chemicals, Section 1 Test No. 111: Hydrolysis as a Function of pH


Book Description

This Test Guideline describes a laboratory test method to assess abiotic hydrolytic transformations of chemicals in aquatic systems at pH values normally found in the environment (pH 4 – 9). This Guideline is designed as a tiered approach; each tier ...




OECD Guidelines for the Testing of Chemicals, Section 1 Test No. 123: Partition Coefficient (1-Octanol/Water): Slow-Stirring Method


Book Description

This Test Guideline describes the slow-stirring method, which permits the determination of the 1-octanol/water partition coefficient (POW) values up to a log POW of 8.2. The partition coefficient between water and 1-octanol (POW) is defined as the ...




OECD Guidelines for the Testing of Chemicals, Section 1 Test No. 106: Adsorption -- Desorption Using a Batch Equilibrium Method


Book Description

This Test Guideline is aimed at estimating the adsorption/desorption behaviour of a chemical on different soil types. The goal is to obtain a sorption value which can be used to predict partitioning under a variety of environmental conditions; to ...




OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319B: Determination of in vitro intrinsic clearance using rainbow trout liver S9 sub-cellular fraction (RT-S9)


Book Description

The Test Guideline (TG) describes the use of liver S9 sub-cellular fraction (RT-S9) of rainbow trout (Oncorhynchus mykiss) as a metabolising system to determine the clearance (CL, IN VITRO, INT ) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the ...




OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure


Book Description

This Test Guideline describes a procedure for characterising the bioconcentration potential of substances in fish, using an aqueous (standard and minimised tests) or dietary exposure, under flow-through conditions (but semi-static regimes are ...







OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 319A: Determination of in vitro intrinsic clearance using cryopreserved rainbow trout hepatocytes (RT-HEP)


Book Description

The Test Guideline (TG) describes the use of cryopreserved rainbow trout (Oncorhynchus mykiss) hepatocytes (RT-HEP) as a metabolising system to determine the clearance (CL, IN VITRO, INT) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the RT-HEP ...




OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP)


Book Description

In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...




OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 318: Dispersion Stability of Nanomaterials in Simulated Environmental Media


Book Description

This test guideline describes a test procedure to gain information on dispersion stability of manufactured nanomaterials in simulated environmental media. The main purpose of this guideline is to assess the ability of a nanomaterial to attain a colloidal dispersion and to conserve this ...




OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 314: Simulation Tests to Assess the Biodegradability of Chemicals Discharged in Wastewater


Book Description

This Test Guideline describes a method to assess the extent and kinetics of primary and ultimate biodegradation of organic chemicals whose route of entry into the environment begins with their discharge to wastewater. It consists of five simulation ...