Opportunistic Adaptation


Book Description

Urban climate adaptation currently focusses mainly on hazards but often ignores opportunities which arise in both space and time. Opportunistic Adaptation provides a rationalized approach to mainstream measures for climate adaptation into urban renewal cycles. Adaptation opportunities are identified by projecting the lifespans of urban assets into the future to obtain an operational urban adaptation agenda for the future. Upscaling of the adaptation process is done by synchronizing the end-of-lifecycle of a group of assets to develop adaptation clusters that comprise multiple dwellings, infrastructure as well as public spaces. An extensive catalogue of adaptation measures for different scale-levels ensures flexibility in the type of measures that can be integrated. Sequencing the adaptation measures over long periods of time provides insight and flexibility in the long-term protection standards that can be achieved. By applying a design-centered approach, the potentials of obtaining co-benefits in the urban landscape are maximized. Potentials of clustering of nature-based solutions are being considered which ensures to maximize the delivery of ecosystem services. This research aims to assess \the adaptation potential of Bangkok, based on a case study area (Lat Krabang) by mapping the adaptation opportunities and flood vulnerability. The resulting outputs will contribute to the development of a flexible and inclusive FRM strategy.




Genomic Adaptation for Organohalide Respiration of Vinyl Chloride and Other Priority Pollutants by the Anaerobic Bacterium Dehalococcoides


Book Description

Vinyl chloride (VC) is a widespread groundwater pollutant and Group 1 carcinogen. Microbial respiration of VC is both critical for complete remediation of chloroethenes in situ, and a unique physiology only observed by certain strains of Dehalococcoides. Two different genes independently encoding VC respiration in Dehalococcoides, vcrA and bvcA, were identified previously, each a member of the diverse family of reductive dehalogenase homologous genes, or rdhA. In this thesis I report that vcrA and bvcA are among a subset of putative 'foreign' rdhA with a low GC3 codon usage that favors the nucleotide T, even though tRNAs recognizing T-ending codons are categorically absent in Dehalococcoides genomes. Comparative genomics of the first two complete genome sequences of microorganisms able to respire VC, Dehalococcoides strains VS and BAV1, reveals that vcrA and bvcA are both located within recently integrated, but different, genomic islands (GIs). These islands have different predicted integration sites and different relative positions in the genome, suggesting that bvcA and vcrA were acquired independently and through different mechanisms. In particular, the vcrA-containing GI appears to have integrated at the single-copy tmRNA encoding gene, ssrA, along with many other homologous elements that site-specifically integrate/excise at ssrA -- some of which contain other rdhA. A detailed analysis of these 'ssrA-GIs' in Dehalococcoides identifies the precise position of insertion as well as a conserved module of syntenic integration-associated genes that includes the likely ssrA-specific integrase. Further analysis of (meta)genomic data, as well as targeted sequencing from 4 additional VC-respiring cultures, provided a total of 8 syntenic vcr-GIs from independently derived cultures. Evolutionary estimates for the age of divergence of these 8 vcrA sequences is not confidently distinguishable from the first industrial synthesis of chlorinated ethenes approximately 100 years ago. By contrast, the estimated age of divergence of Dehalococcoides strains far precedes industrial civilization. Overall, ssrA-GIs appear to be a major contributor to the second of two high plasticity regions, genetically dynamic regions that interrupt an otherwise stable, syntenic, and streamlined Dehalococcoides genome -- among the smallest of any free living microorganism. The apparent compartmentalization of Dehalococcoides genome dynamics within specialized regions may enhance opportunistic adaptation to (new) organohalide respiratory niches while protecting a core genome that is highly adapted to life in the anoxic subsurface, exemplified here by the recent site-specific acquisition of VC reductase genes.




Organisational Adaptations


Book Description

This book explores how enterprises adapt to challenges in their business environments. It focuses on the critical elements within organisations that every executive must address in order to remain competitive. It takes a pluralist approach in trying to broaden our knowledge on organisational adaptations. It also offers an exploratory delve into existing literature of organisational study. This is biased for content, context and process framework and processual analytic approach in order to identify, determine, understand the intricacies of adaptations going on in various business organisations. The book also includes a case study of how Kodak and Fujifilm responded to digitalisation of photographic film industry, which is an example of major adaptation change. Many global brands are often contending with similar issues and real life challenges. Simply put, today’s business environment demands a new way of doing business that challenges brand’s existing core business philosophy. Organisations are ‘individual’ entities in their own rights. Businesses have devised ways of surviving their environments. They do this by downsizing, merger and acquisition, business ecosystems, other forms of collaborations and strategic alliances. While this is true, current research works into generic predictors and/or concepts that enhance the transformation process are scarce. It is particularly important to align the theories and concepts of organisational adaptations with realities in the business environment. This book delves deep and explains adaptations in organisations, but also offers insight for how executives can adapt and thrive in their dynamic business environments.




Human Adaptation and Accommodation


Book Description

A text that explores how humans adapt to conditions of physical stress




Research Handbook of Policy Design


Book Description

This visionary Research Handbook presents the state of the art in research on policy design. By conceiving policy design both as a theoretical and a methodological framework, it provides scholars and practitioners with guidance on understanding policy problems and devising accurate solutions.




The Origin and Evolution of New Businesses


Book Description

What is this mysterious activity we call entrepreneurship? Does success require special traits and skills or just luck? Can large companies follow their example? What role does venture capital play? In a field dominated by anecdote and folklore, this landmark study integrates more than ten years of intensive research and modern theories of business and economics. The result is a comprehensive framework for understanding entrepreneurship that provides new and penetrating insights. Examining hundreds of successful ventures, the author finds that the typical business has humble, improvised origins. Well-planned start-ups, backed by substantial venture capital, are exceptional. Entrepreneurs like Bill Gates and Sam Walton initially pursue small, uncertain opportunities, without much capital, market research, or breakthrough technologies. Coping with ambiguity and surprises, face-to-face selling, and making do with second-tier employees is more important than foresight, deal-making, or recruiting top-notch teams. Transforming improvised start-ups into noteworthy enterprises requires a radical shift, from "opportunistic adaptation" in niche markets to the pursuit of ambitious strategies. This requires traits such as ambition and risk-taking that are initially unimportant. Mature corporations have to pursue entrepreneurial activity in a much more disciplined way. Companies like Intel and Merck focus their resources on large-scale initiatives that scrappy entrepreneurs cannot undertake. Their success requires carefully chosen bets, meticulous planning, and the smooth coordination of many employees rather than the talents of a driven few. This clearly and concisely written book is essential for anyone who wants to start a business, for the entrepreneur or executive who wants to grow a company, and for the scholar who wants to understand this crucial economic activity.




Case-Based Reasoning Research and Development


Book Description

This book constitutes the refereed proceedings of the 24th International Conference on Case-Based Reasoning Research and Development, ICCBR 2016, held in Atlanta, GA, USA, in October/November 2016. The 14 revised full papers presented were carefully reviewed and selected from 44 submissions. The papers cover a wide range of CBR topics that are of interest both to researchers and practitioners from foundations of Case-Based Reasoning; over CBR systems for specific tasks and related fields; up to CBR systems, applications and lessons learned in specific areas of expertise such as health; e-science; finance; energy, logistics, traffic; game/AI; cooking; diagnosis, technical support; as well as knowledge and experience management.




A Changing Environment for Human Security


Book Description

Environmental change presents a new context and new opportunities for transformational change. This timely book will inspire new ways of understanding the relationship between environmental change and human security. A Changing Environment for Human Security: Transformative Approaches to Research, Policy and Action both supports and informs a call for new, transformative approaches to research, policy and action. The chapters in this book include critical analyses, case studies and reflections on contemporary environmental and social challenges, with a strong emphasis on those related to climate change. Human thoughts and actions have contributed to an environment of insecurity, manifested as multiple interacting threats that now represent a serious challenge to humanity. Yet humans also have the capacity to collectively transform the economic, political, social and cultural systems and structures that perpetuate human insecurities. These fresh perspectives on global environmental change from an interdisciplinary group of international experts will inspire readers – whether students, researchers, policy makers, or practitioners – to think differently about environmental issues and sustainability. The contributions show that in a changing environment, human security is not only a possibility, but a choice.




Case-Based Reasoning Research and Development


Book Description

This book constitutes the refereed proceedings of the 8th International Conference on Case-Based Reasoning, ICCBR 2009, held in Seattle, WA, USA, in July 2009. The 17 revised full papers and 17 revised poster papers presented together with 2 invited talks were carefully reviewed and selected from 55 submissions. Covering a wide range of CBR topics of interest both to practitioners and researchers, the papers are devoted to theoretical/methodological as well as to applicative aspects of current CBR analysis.




Case-Based Reasoning Research and Development


Book Description

This book constitutes the proceedings of the 29th International Conference on Case-Based Reasoning, ICCBR 2021, which took place in Salamanca, Spain, during September 13-16, 2021. The 21 papers presented in this volume were carefully reviewed and selected from 85 submissions. They deal with AI and related research focusing on comparison and integration of CBR with other AI methods such as deep learning architectures, reinforcement learning, lifelong learning, and eXplainable AI (XAI).




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