Introduction to Basics of Pharmacology and Toxicology


Book Description

This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.




In Praise Of Imperfe


Book Description

The autobiography of Levi-Montalcini, who won the Nobel Prize for Medicine in 1986. Born in Torino into a middle-class Jewish family, she experienced the rise of fascism and antisemitism in the 1930s-40s (discussed on pp. 73-105). After the promulgation of the racial laws in 1938, it was impossible for her to pursue research at the Neurological Clinic and she continued her work in private. She survived the war hiding in a small town in Italy and later emigrated to the United States.




Perspectives of Stem Cells


Book Description

Stem cells are fascinating cell types. They can replicate themselves forever while retaining the potential to generate progeny with speci?c functions. Because of these special properties, stem cells have been subjects of intensive investigation, from understanding basic mechanisms underlying tissue generation, to modeling human diseases, to application for cell replacement therapy. Stem cells come in different forms. For example, mouse embryonic stem cells can general all cell types in a body, either in a dish or when put back into mouse embryos. On the other hand, neural stem cells in the adult brain generate neurons and glia cells that contribute to the brain’s plasticity. Rapid progress has been made in the stem cell ?eld with discov- ies published in a record speed. A quick Pubmed search has returned 2789 hits for “embryonic stem cells” and 815 hits for “adult neural stem cells/neurogenesis” in the year 2008 alone. It remains a taunting task for all who are interested in stem cells to keep up with rapidly accumulating literatures. The “Perspectives of Stem Cells” by a truly international team of experts provides a timely and invaluable highlight of the stem cell ?eld gearing toward future therapeutic applications in the nervous system. Stem cells with neural potentials have attracted a lot of attention because of their promise for cell replacement therapy, ranging from degenerative neurological dis- ders to spinal cord injuries.




Childhood Acute Lymphoblastic Leukemia


Book Description

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.




Cytometry, Part A


Book Description

Each chapter presents a detailed background of the described method, its theoretical foundations, and its applicability to different biomedical material. Updated chapters describe either the most popular methods or those processes that have evolved the most since the past edition. Additionally, a large portion of the volume is devoted to clinical cytometry. Particular attention is paid to applications of cytometry in oncology, the most rapidly growing area. - Contains 56 extensive chapters authored by world authorities on cytometry - Covers a wide range of topics, including principles of cytometry and general methods, cell preparation, tandardization and quality assurance, cell proliferation, apoptosis, cell-cell/cell-environmental interactions, cytogenetics and molecular genetics, cell function and differentiation, experimental and clinical oncology, microorganisms, and infectious diseases - Describes in-depth the essential methods and scientific principles of flow and laser scanning cytometry and illustrates how they can be applied to the fields of biology and medicine - Complements the first and second editions on flow cytometry in the Methods in Cell Biology series and includes new sections on technology principles




P-adic Aspects Of Modular Forms


Book Description

The aim of this book is to give a systematic exposition of results in some important cases where p-adic families and p-adic L-functions are studied. We first look at p-adic families in the following cases: general linear groups, symplectic groups and definite unitary groups. We also look at applications of this theory to modularity lifting problems. We finally consider p-adic L-functions for GL(2), the p-adic adjoint L-functions and some cases of higher GL(n).




Molecular Infection Biology


Book Description

This comprehensive volume focuses on molecular methods and principles of prokaryotic and eukaryotic pathogens. The authors present the molecular and cellular aspects by focusing on the interactions between pathogenic microorganisms and their hosts. The publication begins with an overview of the most important and dangerous causative agents of infectious diseases. Next are discussions of how microbial "weapons," pathogenicity factors, protein secretion machines, and surface variation systems work, presenting the molecular and genetic methods that are used by scientists for their discovery and analysis. Furthermore, infectious diseases are discussed in light of the newly formed research areas of evolutionary and cellular microbiology and genomics. Future aspects on diagnostic techniques, therapy, and vaccine development are also presented.




Medicinal Chemistry and Pharmacology


Book Description

Medicinal chemistry and pharmacology are closely associated fields. They are concerned with the design and synthesis of drugs for the pharmaceutical industry. These drugs are generally organic compounds and can be divided into classes of biologics and small organic compounds. Medicinal chemistry is focused on the production of small organic molecules such as atorvastatin, fluticasone, clopidogrel, etc. The principles of synthetic organic chemistry, computational chemistry, enzymology, structural biology and chemical biology are integrated in medicinal chemistry. The study of drugs and their effects on the living body are explored in pharmacology. It involves the research, discovery and characterization of the chemicals that exhibit a biological effect. All therapies that are designed to target diseases, defects and pathogens and also advance preventive care, diagnostics and personalized medicine are a result of tremendous research in pharmacology. This book is a compilation of chapters that discuss the most vital concepts and emerging trends in the fields of medicinal chemistry and pharmacology. The various advancements in these fields are glanced at and their applications as well as ramifications are looked at in detail. This book is a vital tool for all researching and studying pharmaceutical science and medicinal chemistry.




Hearing Impairment and Disability


Book Description

"Much research has been conducted to provide researchers and hearing healthcare professionals with updated information in regard to hearing assessments, results interpretation and case management. This ongoing research is particularly imperative to guide clinicians with optimized methods in assessing and managing pediatric patients with hearing impairment and disability. As such, tremendous research efforts have been made in determining the most optimum methods in assessing hearing using both subjective and objective tests. Since hearing loss can occur due to disrupted peripheral and/or central auditory pathway, there is also a growing interest to study children with auditory processing disorder (APD). Even though notable achievements have been observed in understanding APD, more research is required, particularly in establishing a gold standard APD test and its specific interventions. Aditionally, having an objective test such as speech-evoked auditory brainstem response is beneficial to understand how speech sounds are encoded within the brainstem region in hearing-impaired children, as well as in those with compromised neural function. In this book, we have gathered research from Malaysia and India in this field and hope it will be of interest to our readers"--




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