Quinine's Remains


Book Description

A free ebook version of this title is available through Luminos, University of California Press's Open Access publishing program. Visit www.luminosoa.org to learn more. What happens after colonial industries have run their course—after the factory closes and the fields go fallow? Set in the cinchona plantations of India’s Darjeeling Hills, Quinine’s Remains chronicles the history and aftermaths of quinine. Harvested from cinchona bark, quinine was malaria’s only remedy until the twentieth-century advent of synthetic drugs, and it was vital to the British Empire. Today, the cinchona plantations—and the roughly fifty thousand people who call them home—remain. Their futures, however, are unclear. The Indian government has threatened to privatize or shut down this seemingly obsolete and crumbling industry, but the plantation community, led by strident trade unions, has successfully resisted. Overgrown cinchona fields and shuttered quinine factories may appear the stuff of postcolonial and postindustrial ruination, but quinine’s remains are not dead. Rather, they have become the site of urgent efforts to redefine land and life for the twenty-first century. Quinine's Remains offers a vivid historical and ethnographic portrait of what it means to forge life after empire.




Malarial Subjects


Book Description

This book examines how and why British imperial rule shaped scientific knowledge about malaria and its cures in nineteenth-century India. This title is also available as Open Access.




Hepatotoxicity


Book Description

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.




Saving Lives, Buying Time


Book Description

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.




Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis


Book Description

Among the many who serve in the United States Armed Forces and who are deployed to distant locations around the world, myriad health threats are encountered. In addition to those associated with the disruption of their home life and potential for combat, they may face distinctive disease threats that are specific to the locations to which they are deployed. U.S. forces have been deployed many times over the years to areas in which malaria is endemic, including in parts of Afghanistan and Iraq. Department of Defense (DoD) policy requires that antimalarial drugs be issued and regimens adhered to for deployments to malaria-endemic areas. Policies directing which should be used as first and as second-line agents have evolved over time based on new data regarding adverse events or precautions for specific underlying health conditions, areas of deployment, and other operational factors At the request of the Veterans Administration, Assessment of Long-Term Health Effects of Antimalarial Drugs When Used for Prophylaxis assesses the scientific evidence regarding the potential for long-term health effects resulting from the use of antimalarial drugs that were approved by FDA or used by U.S. service members for malaria prophylaxis, with a focus on mefloquine, tafenoquine, and other antimalarial drugs that have been used by DoD in the past 25 years. This report offers conclusions based on available evidence regarding associations of persistent or latent adverse events.




Therapy in Nephrology and Hypertension E-Book


Book Description

Thoroughly revised, the new edition of this companion to Brenner & Rector’s The Kidney equips you with today’s guidance to effectively manage renal and hypertension patients. International authorities emphasize the specifics of treatment while presenting field-tested advice on the best therapeutic strategies available. New chapters reflect the latest evidence impacting current clinical issues, while a new design helps you reference the information more easily. Presents the most comprehensive text available on nephrology and hypertension treatment for a convenient single source that is easy to consult. Features the evidence-based guidance of leading authorities for making more informed clinical decisions. Offers in-depth discussions and referenced coverage of key trials to help you analyze the results and the evidence provided. Provides treatment algorithms and tables of commonly used drugs in each chapter for quick-access expert advice on arriving at the best and most appropriate treatment regimen. Offers new chapters on erectile and sexual dysfunction, transplant immunology and immunosuppression, dietary salt restriction, and systematic vasculitis and pauci-immune glomerulonephritis that reflect new evidence impacting current clinical issues. Presents the contributions of newly assigned section editors—authorities in their subspecialty fields—who offer you the benefit of their practice-proven expertise. Provides rationales for the therapies presented to help you choose the most effective treatment for each patient.




Pain Review E-Book


Book Description

Easy to read and easy to use, Pain Review, 2nd Edition provides you with the most up-to-date, comprehensive review of pain medicine available. Written by Steven Waldman, MD, a leading author in the specialty of pain medicine, this book gives you exactly what you need – an easily understandable, targeted review of the essential basic science; beautifully illustrated, full-color anatomic figures; and a comprehensive review of common and uncommon pain syndromes, as well as how-to-do-it explanations of all of the pain management injection and nerve block techniques that every practitioner needs to know. Pain Review, 2nd Edition is an excellent tool for reviewing the specialty and for preparing for your pain medicine board review, recertification, or for the practice of pain medicine. Provides the reader with clearly written review of the signs, symptoms and physical findings of 95 defined pain syndromes classified by body region. Presents an easy-to-follow, generously illustrated, step-by step roadmap of how to perform 113 individual nerve blocks and injection techniques, as well as a review of associated pitfalls and complications. Follows an easy-to-read templated format throughout for quick mastery and retrieval of information, closely matching the format and content of the American Board of Anesthesiology pain medicine board certification exam. Maintains a consistent approach and editorial style as a single-authored text by noted authority Steven D. Waldman, MD. NEW! Conceptual illustrations are now in full color to help you better visualize injection techniques. Hundreds of NEW full color tables and figures simplify learning. NEW, updated design offers visual appeal and ease of use. Updated references throughout direct you to the most up-to-date source material.




Drug Metabolism in Diseases


Book Description

Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. Each chapter clearly presents the effects of changes in drug metabolism and drug transporters on pharmacokinetics and disposition. This is a unique and useful approach for all those involved in drug discovery and development, and for clinicians and researchers in drug metabolism, pharmacology, and clinical pharmacology. Written and edited by leaders in drug metabolism from academia and industry Covers important topics, such as pharmacogenomics, drug metabolism in transplant patients, xenobiotic receptors, drug metabolism in geriatric and pediatric populations, and more Highlights topics of importance in drug discovery and development, and for safe and effective drug use in the clinic




Malaria


Book Description

Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.




Quinine's Remains


Book Description

A free ebook version of this title is available through Luminos, University of California Press's Open Access publishing program. Visit www.luminosoa.org to learn more. What happens after colonial industries have run their course—after the factory closes and the fields go fallow? Set in the cinchona plantations of India’s Darjeeling Hills, Quinine’s Remains chronicles the history and aftermaths of quinine. Harvested from cinchona bark, quinine was malaria’s only remedy until the twentieth-century advent of synthetic drugs, and it was vital to the British Empire. Today, the cinchona plantations—and the roughly fifty thousand people who call them home—remain. Their futures, however, are unclear. The Indian government has threatened to privatize or shut down this seemingly obsolete and crumbling industry, but the plantation community, led by strident trade unions, has successfully resisted. Overgrown cinchona fields and shuttered quinine factories may appear the stuff of postcolonial and postindustrial ruination, but quinine’s remains are not dead. Rather, they have become the site of urgent efforts to redefine land and life for the twenty-first century. Quinine's Remains offers a vivid historical and ethnographic portrait of what it means to forge life after empire.