› › Resistance To Immunotoxins In Cancer Therapy

Resistance to Immunotoxins in Cancer Therapy

Author : Rama Shanker Verma

Publisher : Springer

Page : 259 pages

File Size : 39,16 MB

Release : 2015-06-11

Category : Medical

ISBN : 3319172751

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Book Description

This book will be a guide to understanding resistance against targeted therapeutic approaches for cancer using immunotoxins. It contains a detailed review of the history and development of targeted therapy. As well, it includes an in-depth description of the molecular and cellular mechanisms involved in cancer resistance and several novel methods to overcome resistance. Each chapter discusses different aspects of resistance and covers all the factors that may contribute to resistance in cancer cells. Finally, this volume highlights the recent findings and advances associated with tackling cancer resistance.



Chimeric Toxins

Author : Haya Lorberboum-Galski

Publisher : CRC Press

Page : 288 pages

File Size : 16,32 MB

Release : 2002-05-30

Category : Medical

ISBN : 0203216474

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Book Description

Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action are common to many of these toxins and represent general pathways for the interaction of a number of biomolecules with target cells, such as binding to specific surface receptors, internalizati



Medicinal Chemistry of Anticancer Drugs

Author : Carmen Avendaño

Publisher : Elsevier

Page : 767 pages

File Size : 20,68 MB

Release : 2015-06-11

Category : Science

ISBN : 0444626670

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Book Description

Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature



Translational Immunotherapy of Brain Tumors

Author : John H. Sampson

Publisher : Academic Press

Page : 406 pages

File Size : 19,93 MB

Release : 2017-02-06

Category : Medical

ISBN : 0128026251

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Book Description

Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. 2018 BMA Medical Book Awards Highly Commended in Oncology - Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas - Edited by a prominent neurosurgeon with contributions by leading researchers in the field - Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors



Encyclopedia of Cancer

Author : Manfred Schwab

Publisher : Springer Science & Business Media

Page : 3307 pages

File Size : 29,85 MB

Release : 2008-09-23

Category : Medical

ISBN : 3540368477

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Book Description

This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.



Antibody Fusion Proteins

Author : Steven M. Chamow

Publisher : Wiley-Liss

Page : 312 pages

File Size : 14,79 MB

Release : 1999-04-13

Category : Science

ISBN : 9780471183587

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Book Description

Thoroughly detailed and illustrated, this book examines the construction, properties, applications, and problems associated with specific types of fusion molecules used in clinical and research medicine. The editors present an overview of the field, followed by nine chapters divided into two general sections based on the two primary parts of the antibody molecule: Fab fusion proteins and Fc fusion proteins. In addition, numerous renowned scientists in the field have contributed outlines demonstrating man-made molecules that will be required not only to overcome the limitations of monoclonal antibodies, but also to extend the principle of selective targeting. Divided into specific, accessible sections, Antibody Fusion Proteins includes: * Chapters describing Fc fusion proteins, as well as several classes of antigen-binding proteins * Complete details on the design and molecular construction of genetically engineered fusion molecules * Useful information on molecular purification, large-scale production, practical applications, and their therapeutic potential * The latest data on forming fusion proteins with toxins, cytokines, or enzymes that can activate a prodrug



The Molecular Basis of Cancer

Author : John Mendelsohn

Publisher : Elsevier Health Sciences

Page : 1948 pages

File Size : 20,7 MB

Release : 2008-04-01

Category : Medical

ISBN : 1437710999

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Book Description

Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.



Polyether Antibiotics

Author : J. W. Westley

Publisher : CRC Press

Page : 432 pages

File Size : 40,27 MB

Release : 2019-12-02

Category :

ISBN : 9780367451929

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Book Description

This collection of essays will stimulate the use of ionophores in different research areas. It includes information on potential breakthroughs in the halogenated derivatives of lasalocid and ethers of antibiotic A204A, polyethers and analytical techniques used to unravel their complex structures.



The Collected Papers of Paul Ehrlich

Author : F. Himmelweit

Publisher : Elsevier

Page : 678 pages

File Size : 31,67 MB

Release : 2017-01-31

Category : Science

ISBN : 1483139832

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Book Description

The Collected Papers of Paul Ehrlich, Volume I covers topics on histology, biochemistry, and pathology. The book presents topics on practice and theory of staining in histology; cytology of the blood in health and disease; and the staining of bacteria and its application to diagnosis. The text also includes topics on the requirement of the organism for oxygen and other allied biochemical studies; pharmacology, therapeutics and toxicology; and the diazobenzenesulphonic acid and dimethylaminobenzaldehyde reactions.



Antibody-Drug Conjugates and Immunotoxins

Author : Gail Lewis Phillips

Publisher : Springer Science & Business Media

Page : 370 pages

File Size : 37,88 MB

Release : 2012-12-13

Category : Medical

ISBN : 1461454565

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Book Description

This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.