HIV and the Blood Supply


Book Description

During the early years of the AIDS epidemic, thousands of Americans became infected with HIV through the nation's blood supply. Because little reliable information existed at the time AIDS first began showing up in hemophiliacs and in others who had received transfusions, experts disagreed about whether blood and blood products could transmit the disease. During this period of great uncertainty, decision-making regarding the blood supply became increasingly difficult and fraught with risk. This volume provides a balanced inquiry into the blood safety controversy, which involves private sexual practices, personal tragedy for the victims of HIV/AIDS, and public confidence in America's blood services system. The book focuses on critical decisions as information about the danger to the blood supply emerged. The committee draws conclusions about what was doneâ€"and recommends what should be done to produce better outcomes in the face of future threats to blood safety. The committee frames its analysis around four critical area: Product treatmentâ€"Could effective methods for inactivating HIV in blood have been introduced sooner? Donor screening and referralâ€"including a review of screening to exlude high-risk individuals. Regulations and recall of contaminated bloodâ€"analyzing decisions by federal agencies and the private sector. Risk communicationâ€"examining whether infections could have been averted by better communication of the risks.




Screening Donated Blood for Transfusion-transmissible Infections


Book Description

"Blood transfusion is a life-saving intervention that has an essential role in patient management within health care systems. All Member States of the World Health Organization (WHO) endorsed World Health Assembly resolutions WHA28.72 (1) in 1975 and WHA58.13 (2) in 2005. These commit them to the provision of adequate supplies of safe blood and blood products that are accessible to all patients who require transfusion either to save their lives or promote their continuing or improving health." --Preface.




Blood Donor Counselling


Book Description

Individuals who donate their blood provide a unique and precious gift in an act of human solidarity. In order to donate blood, prospective donors should be in good health and free from any infections that can be transmitted through transfusion. Most blood donors perceive themselves to be healthy, but some are unsuitable to donate blood due to the potential risk of compromising or worsening their own health or the risk of transmission of infections to patients. Blood transfusion services (BTS) have a duty of care towards blood donors as well as to the recipients of transfusion. This duty of care extends to prospective donors who are deferred from donation--whether on a temporary or permanent basis--as well as those who donate blood and are subsequently found to have unusual or abnormal test results. BTS have a responsibility to confirm test results and provide information, counseling and support to enable these individuals to understand and respond to unexpected information about their health or risk status. Counseling is part of the spectrum of care that a BTS should be able to provide to blood donors--including referral to medical practitioners or specialist clinical services. Pre-donation counseling was recognized as one element of the strategy to reduce and, if possible, prevent the donation of blood by individuals who might be at risk for HIV and other TTI including hepatitis B and C viruses as well as to inform the donor of the donation process and testing of blood for HIV. Post-donation counseling was acknowledged to be a necessary element of donor management as an adjunct to informing donors of unusual or abnormal test results. Blood donor counseling by trained specialist staff is now considered to be a key component of the blood system in most countries with a well-developed blood transfusion service. It may be required at a number of stages in the blood donation process or following blood screening and should be available at any point at which the BTS has an interface with donors. In many countries, however, blood donor counseling is not yet available in a structured way. Blood Donor Counselling: Implementation Guidelines has therefore been developed to provide guidance to blood transfusion services that have not yet established donor counseling programs.




Blood Donor Selection


Book Description

The WHO guidelines on assessing donor suitability for blood donation have been developed to assist blood transfusion services in countries that are establishing or strengthening national systems for the selection of blood donors. They are designed for use by policy makers in national blood programmes in ministries of health, national advisory bodies such as national blood commissions or councils, and blood transfusion services.







WHO Guidelines on Drawing Blood


Book Description

Phlebotomy uses large, hollow needles to remove blood specimens for lab testing or blood donation. Each step in the process carries risks - both for patients and health workers. Patients may be bruised. Health workers may receive needle-stick injuries. Both can become infected with bloodborne organisms such as hepatitis B, HIV, syphilis or malaria. Moreover, each step affects the quality of the specimen and the diagnosis. A contaminated specimen will produce a misdiagnosis. Clerical errors can prove fatal. The new WHO guidelines provide recommended steps for safe phlebotomy and reiterate accepted principles for drawing, collecting blood and transporting blood to laboratories/blood banks.




WHO Best Practices for Injections and Related Procedures Toolkit


Book Description

The new WHO guidelines provide recommended steps for safe phlebotomy and reiterate accepted principles for drawing, collecting blood and transporting blood to laboratories/blood banks. The main areas covered by the toolkit are: 1. bloodborne pathogens transmitted through unsafe injection practices;2. relevant elements of standard precautions and associated barrier protection;3. best injection and related infection prevention and control practices;4. occupational risk factors and their management.




Animals and Medicine


Book Description

Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.




Guidance on ensuring a sufficient supply of safe blood and blood components during emergencies


Book Description

This guidance document has been produced by the World Health Organization (WHO) to assist blood services in the development of national plans to respond to any disaster, major incident or emergency that threatens sufficiency or safety of the blood supply. Such situations can be caused by natural forces, by factors influenced by humans or directly caused by humans. This document is intended to guide the national blood service through the process of planning how to respond in a timely, controlled and appropriate way to emergencies. In the preparation of the document, WHO has tried to include the elements that blood services or providers might need to consider, providing some background on the reasons for their inclusion and guidance on different response options that may be available. The consequences of an emergency may include interruption of blood supply due to a shortage of blood donors, or to a disrupted supply of critical materials and equipment used in blood collection, component preparation and laboratory testing, resulting in reduced availability of blood and blood components. Although the demand for transfusion may decrease in some situations, transfusions continue to be necessary for clinical emergencies and for those patients reliant on long-term transfusion support. In contrast, some emergencies, for instance those resulting in multiple casualties, could lead to a rapid surge in demand for blood over a short time. The challenge is to maintain essential transfusion services as well as responding to the emergency. Preparedness, including business continuity planning, is essential for blood services to mitigate the impact of emergencies. Preparation should be underpinned by locally sensitive risk assessment using relevant data at the local or country level. However, it is not possible to predict the nature of every situation that could impact on the blood supply, and it is therefore expected that blood services will review the elements in this document as well as assessing their own situation, needs, capabilities and resources, along with any additional relevant country-specific factors, in the development of their own response plans. Planning should consider the concurrence and combinations of events and the response should be proportionate and coordinated with others. The aim is to maintain critical services and prepare for recovery. Staff training and support is key to resilience. It is acknowledged that as well as affecting the sufficiency and safety of blood supply, major incidents in countries undertaking transplantation may threaten the safety and sufficiency of the supply of other products of human origin, such as cells, tissues and organs. Increasingly, blood services are taking overall national responsibility for transplantation in their capacity as the organization responsible for the collection, processing, storage and supply of cells, tissues and organs. This approach is both sensible and appropriate, as the overall donor selection and screening processes are the same or very similar. This guidance document can therefore also be used to assist those bodies responsible for the provision of cells, tissues and organs to prepare for emergencies. Resilience to disasters and emergencies requires a commitment to the blood supply and transfusion system as an integral part of the health care system.




Toward a Sustainable Blood Supply in the United States


Book Description

This report aims to describe the U.S. blood system, identify and discuss potential threats to the functioning and sustainability of the blood system, and describe recommendations with the potential to improve the sustainability of the blood system.