› › Special Focus On The Biology Of Aging

Biology of Aging

Author : Robert Arking

Publisher : Oxford University Press

Page : 619 pages

File Size : 47,9 MB

Release : 2006-02-02

Category : Family & Relationships

ISBN : 0195167392

Get eBook

Book Description

Robert Arking's Biology of Aging is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging.



Biochemistry and Cell Biology of Ageing: Part II Clinical Science

Author : J. Robin Harris

Publisher : Springer

Page : 502 pages

File Size : 21,74 MB

Release : 2019-03-19

Category : Medical

ISBN : 9811336814

Get eBook

Book Description

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.





An Introduction to Biological Aging Theory

Author : Theodore Goldsmith

Publisher : Azinet

Page : 31 pages

File Size : 29,33 MB

Release : 2011-05-08

Category : Medical

ISBN : 0978870913

Get eBook

Book Description

Why do we age? The answer to this question is critical to our ability to prevent and treat highly age-related diseases such as cancer and heart disease that now cause the deaths of most people in the developed world. This short book provides an overview of biological aging theories including history, current status, major scientific controversies, and implications for the future of medicine. Major topics include: human mortality as a function of age, aging mechanisms and processes, the programmed vs. non-programmed aging controversy, empirical evidence on aging, and the feasibility of anti-aging and regenerative medicine. Evolution theory is essential to aging theories. Theorists have been struggling for 150 years to explain how aging, deterioration, and consequent death fit with Darwin’s survival of the fittest concept. This book explains how continuing genetics discoveries have produced changes in the way we think about evolution that in turn lead to new thinking about the nature of aging.



Epigenetics of Aging

Author : Trygve O. Tollefsbol

Publisher : Springer Science & Business Media

Page : 462 pages

File Size : 22,31 MB

Release : 2009-11-11

Category : Medical

ISBN : 1441906398

Get eBook

Book Description

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.



Epigenetics of Aging and Longevity

Author : Alexey Moskalev

Publisher : Academic Press

Page : 546 pages

File Size : 13,82 MB

Release : 2017-11-17

Category : Medical

ISBN : 012811083X

Get eBook

Book Description

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. - Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease - Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory - Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan



Physical Change and Aging

Author : Sue V. Saxon, PhD

Publisher : Springer Publishing Company

Page : 513 pages

File Size : 17,56 MB

Release : 2009-11-09

Category : Social Science

ISBN : 0826104479

Get eBook

Book Description

"[This book] has been honedÖinto an elegant compendium. This outstanding work should be widely read -- it is perhaps the best example of an integrative approach to gerontology." Score: 94, 4 stars --Doody's This book serves as an authoritative textbook and guide to the physical changes and common pathologies associated with the aging process, with special emphasis on the psychological and social implications of these changes in the lives of older adults. This fifth edition presents the newly available research findings that differentiate "normal" aging from actual pathology. The authors provide a thoroughly updated and expanded review of important topics in aging, including death and grieving, complementary and alternative therapies, nutrition, exercise, and much more. The book also demonstrates how the elderly population can gain greater personal control over aging through lifestyle modifications and preventive health strategies. Key topics introduced and discussed: Psychosocial theories of aging Changes and disorders in the skeletal, nervous, cardiovascular, and respiratory systems Dementia, delirium, and mild cognitive impairment Aging in persons with lifelong disabilities This volume serves as a comprehensive textbook for students studying to become health care professionals, and is also a fundamental resource for gerontologists, nurses, social workers, psychologists, rehabilitation specialists, clergy, and counselors.



Stem Cells and Aging

Author : Surajit Pathak

Publisher : Academic Press

Page : 322 pages

File Size : 29,26 MB

Release : 2021-03-17

Category : Science

ISBN : 0128204133

Get eBook

Book Description

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. - Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population - Addresses the effect of time and age on human stem cells - Includes chapters from contributors exploring the biology of stem cell aging around the globe



Handbook of Models for Human Aging

Author : P. Michael Conn

Publisher : Elsevier

Page : 1103 pages

File Size : 19,82 MB

Release : 2011-04-28

Category : Medical

ISBN : 0080460062

Get eBook

Book Description

The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. - Utilizes a multidisciplinary approach - Shows tricks and approaches not available in primary publications - First volume of its kind to combine both methods of study for human aging and animal models - Over 200 illustrations



Health, Illness, and Optimal Aging

Author : Carolyn M. Aldwin

Publisher : SAGE

Page : 446 pages

File Size : 17,53 MB

Release : 2004

Category : Family & Relationships

ISBN : 9780761922599

Get eBook

Book Description

In Health, Illness, and Optimal Aging: Biological and Psychosocial Perspectives, Carolyn M. Aldwin and Diane F. Gilmer undertake the challenging task of assembling an objective and holistic picture of human aging. The authors provide comprehensive, multidisciplinary coverage of the physical aspects of aging, including age-related changes and disease-related processes, the demography of the aging population, theories of aging, and the promotion of optimal aging. In addition, the book covers the psychosocial aspects of aging, including mental health, stress and coping, spirituality, and care giving in later years. Health, Illness and Optimal Aging is recommended for researchers seeking an overview of health psychology and aging, as well as undergraduate and graduate students taking classes in the social, behavioral, and health sciences. This text is also valuable for practitioners working with the elderly in fields such as nursing, social work, occupational and physical therapy, day-care and nursing home administration, psychology, and rehabilitation.