Inositol Phospholipid Metabolism and Phosphatidyl Inositol Kinases


Book Description

The development of advanced methods for isolation, identification and quantification of old and new inositol lipids and inositol phosphtes from natural and synthetic systems has been a major advancing force in phosphoinositol research. The writing of this book was undertaken as an opportunity fo examine the analytical validity of the biochemical transformations that constitute the basis of the lipid signaling pathways.




Inositol Phosphates


Book Description

Part I: Chemistry; Part II: Biochemistry.




Phospholipids


Book Description




Phospholipids


Book Description

The book discusses the essential chemistry of phospholipids along with an account of the metabolism. The phospholipases and phospholipase A2 is explained since its structure and the mechanism of its action have been investigated in greater detail than any other phospholipid metabolising enzyme. The increasingly important topic of phospholipid exchange proteins is also treated. Furthermore, since the use of biochemically defined mutants shows great promise for the better understanding of phospholipid biosynthesis and function, the book also discusses genetic control of the enzymes involved.







Function and Metabolism of Phospholipids in the Central and Peripheral Nervous Systems


Book Description

The present volume contains all the contributions and general discussion presented at the International Satellite Meeting on Func tion and Metabolism of Phospholipids in Central and Peripheral Nervous Systems held at Cortona, Tuscany, Italy in August 1975. The Satellite Meeting was organized on the frame of the 5th Inter national Congress of the International Society for Neurochemistry (Barcelona, 2-7 september 1975) and was just run before it. The publication of the scientific content of this volume has been made possible by the collaboration of the speakers, the discussants, the Meeting Chairman, the section chairmen and of all the scientists who have taken part at the Symposium and who deeply and actively discussed the lectures and the contributions to the General Discus sion which were delivered. In order to obtain rapid publication of the volume, however, the single discussions for each delivered contribution will not be reported here. The general subject of membrane structure, of the turnover of its lipid components in CNS and PNS, their functional implica tions and pharmacological actions, was explored in details from the stand-points of the various contributors in biophysics, biochem istry, physiology, cytology, pharmacology and pathology. The whole Symposium was effiCiently introduced and closed by Dr. W. Stoffel. The meeting has been thought to have been very successful.




Inositol phosphates


Book Description




Lipid Metabolism in Signaling Systems


Book Description

Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Major topics covered include: * Techniques for examining the role of phosphoinositides in signal transduction * Techniques related to protein kinase C * Analysis of inositol phosphates * Techniques to analyze phospholipid turnover in the brain




Signalling by Inositides


Book Description

The metabolism and functions of inositol phosphates impinge on various branches of biochemistry, physiology, and molecular biology, and methodological information is in consequence scattered far and wide. This book unites a selection of the most fundamental and commonly used techniques from leading international signal transduction laboratories, and brings together many valuable protocols for purifying and assaying inositides and related compounds. A novel feature is a catalogue of non-commercial sources of synthetic inositide analogues.