The Battle Against Infection


Book Description




The End of Plagues


Book Description

World-renowned immunologist John Rhodes’s The End of Plagues is “an engaging and expansive exploration of humankind’s quest to defend itself against disease” (History Today). At the turn of the twentieth century, smallpox claimed the lives of two million people per year. By 1979, the disease had been eradicated and victory was declared across the globe. Yet the story of smallpox remains the exception, as today a host of deadly contagions, from polio to AIDS, continue to threaten human health around the world. Spanning three centuries, The End of Plagues weaves together the discovery of vaccination, the birth and growth of immunology, and the fight to eradicate the world’s most feared diseases. From Edward Jenner’s discovery of vaccination in 1796, to the early nineteenth-century foundling voyages in which chains of orphans, vaccinated one by one, were sent to colonies around the globe, to the development of polio vaccines and the stockpiling of smallpox as a biological weapon in the Cold War, Rhodes charts our fight against these plagues, and shows how vaccinations gave humanity the upper hand.




Infection & Immunity


Book Description

The authors describe the main causes of infection that our bodies have to battle against - from bacteria to viruses - and explain the intricate and fascinating way that our bodies respond to infection - from detection of these potentially dangerous organisms, to their ultimate elimination




Blood and Germs


Book Description

Acclaimed author Gail Jarrow, recipient of a 2019 Robert F. Sibert Honor Award, explores the science and grisly history of U.S. Civil War medicine, using actual medical cases and first-person accounts by soldiers, doctors, and nurses. The Civil War took the lives of hundreds of thousands of Americans and left countless others with disabling wounds and chronic illnesses. Bullets and artillery shells shattered soldiers' bodies, while microbes and parasites killed twice as many men as did the battles. Yet from this tragic four-year conflict came innovations that enhanced medical care in the United States. With striking detail, this nonfiction book reveals battlefield rescues, surgical techniques, medicines, and patient care, celebrating the men and women of both the North and South who volunteered to save lives.




Disease Control Priorities, Third Edition (Volume 6)


Book Description

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.




Biography of Resistance


Book Description

Award-winning Boston University educator and researcher Muhammad H. Zaman provides a chilling look at the rise of antibiotic-resistant superbugs, explaining how we got here and what we must do to address this growing global health crisis. In September 2016, a woman in Nevada became the first known case in the U.S. of a person who died of an infection resistant to every antibiotic available. Her death is the worst nightmare of infectious disease doctors and public health professionals. While bacteria live within us and are essential for our health, some strains can kill us. As bacteria continue to mutate, becoming increasingly resistant to known antibiotics, we are likely to face a public health crisis of unimaginable proportions. “It will be like the great plague of the middle ages, the influenza pandemic of 1918, the AIDS crisis of the 1990s, and the Ebola epidemic of 2014 all combined into a single threat,” Muhammad H. Zaman warns. The Biography of Resistance is Zaman’s riveting and timely look at why and how microbes are becoming superbugs. It is a story of science and evolution that looks to history, culture, attitudes and our own individual choices and collective human behavior. Following the trail of resistant bacteria from previously uncontacted tribes in the Amazon to the isolated islands in the Arctic, from the urban slums of Karachi to the wilderness of the Australian outback, Zaman examines the myriad factors contributing to this unfolding health crisis—including war, greed, natural disasters, and germophobia—to the culprits driving it: pharmaceutical companies, farmers, industrialists, doctors, governments, and ordinary people, all whose choices are pushing us closer to catastrophe. Joining the ranks of acclaimed works like Microbe Hunters, The Emperor of All Maladies, and Spillover, A Biography of Resistance is a riveting and chilling tale from a natural storyteller on the front lines, and a clarion call to address the biggest public health threat of our time.




The Battle Against Hunger


Book Description

We live in an increasingly prosperous world, yet the estimated number of undernourished people has risen, and will continue to rise with the doubling of food prices. A large majority of those affected are living in India. Why have strategies to combat hunger, especially in India, failed so badly? How did a nation that prides itself on booming economic growth come to have half of its preschool population undernourished? Using the case study of a World Bank nutrition project in India, this book takes on these questions and probes the issues surrounding development assistance, strategies to eliminate undernutrition, and how hunger should be fundamentally understood and addressed. Throughout the book, the underlying tension between choice and circumstance is explored. How much are individuals able to determine their life choices? How much should policy-makers take underlying social forces into account when designing policy? This book examines the possibilities, and obstacles, to eliminating child hunger. This book is not just about nutrition. It is an attempt to uncover the workings of power through a close look at the structures, discourses, and agencies through which nutrition policy operates. In this process, the source of nutrition policy in the World Bank is traced to those affected by the policies in India.




Sepsis Management in Resource-limited Settings


Book Description

This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More than eighty percent of the worldwide deaths related to sepsis occur in resource-limited settings in low and middle-income countries. Current international sepsis guidelines cannot be implemented without adaptations towards these settings, mainly because of the difference in local resources and a different spectrum of infectious diseases causing sepsis. This prompted members of the Global Intensive Care working group of the European Society of Intensive Care Medicine (ESICM) and the Mahidol-Oxford Tropical Medicine Research Unit (MORU, Bangkok, Thailand) - among which the Editors – to develop with an international group of experts a comprehensive set of recommendations for the management of sepsis in resource-limited settings. Recommendations are based on both current scientific evidence and clinical experience of clinicians working in resource-limited settings. The book includes an overview chapter outlining the current challenges and future directions of sepsis management as well as general recommendations on the structure and organization of intensive care services in resource-limited settings. Specific recommendations on the recognition and management of patients with sepsis and septic shock in these settings are grouped into seven chapters. The book provides evidence-based practical guidance for doctors in low and middle income countries treating patients with sepsis, and highlights areas for further research and discussion.




How to Make a Vaccine


Book Description

Understand the Virus -- Explore the Immune System -- Discover a Vaccine -- Develop Vaccines -- Evaluate the Contenders -- Don't Count on the Magic Bullet -- Overcome the Hurdles -- Embrace Many Solutions.