The Cell Surface: Mediator of Developmental Processes


Book Description

The Cell Surface: Mediator of Developmental Processes contains the papers presented at the 38th Symposium of the Society for Developmental Biology, held at the University of British Columbia in Vancouver, Canada in June 1979. The compendium is divided into three parts. The first part provides a summary of the status of the knowledge about the cell surface, which includes the plasma membrane, its associated cytoskeleton and the variety of surface-associated macromolecules. The second portion focuses on the early development of the cell surface. A wide spectrum of techniques, systems, and results in the study of the cell surface are presented. The last part shows a variety of experimental systems in which the cell surface figures prominently in important developmental events. The results from experiments on plant symbiosis, mammalian teratocarcinomas, adhesion and cell shape, and various extracellular macromolecules are detailed extensively. Cytologists, microbiologists, biologists, and other scientists in allied fields will find the publication very insightful.




Cell Biology of Extracellular Matrix


Book Description

At a recent meeting to discuss the domains of cell biology, I put forth a case for the extracellular matrix, even though my argument ran the risk of falling on deaf ears. After all, the matrix is EXTRAcellular, outside the cells. In this book, however, the authors make a compelling case for the relevance of the matrix to cellular concerns. Not only are numerous cell types, including many epithelia, quite caught up in the business of manufacturing matrix components, but also most of them contain matrix molecules in exoskeletons that are attached to the plasmalemma and that organize or otherwise influence the affairs of the cyto plasm. The idea of this book is to present the extracellular matrix to cell biolo gists of all levels. The authors are active and busy investigators, recognized experts in their fields, but all were enthusiastic about the prospect of writing for this audience. The chapters are not "review" articles in the usual sense, nor are they rehashes of symposium talks; they were written specifically for this book and they present the "state of the art" in engaging style, with ample references to more technical or historical reviews. The book is rich in electron micro graphs and diagrams and for many of the latter, as well as for the design of the cover, we are indebted to Sylvia J. Keene, medical illustrator for the Department of Anatomy at Harvard Medical Scrool. We also owe special thanks to Susan G.




Organogenesis of the Kidney


Book Description

Although this description of a model system for cell differentation and organogenesis emphasizes the mammalian kidney, detailed coverage is also given to the development of the transient excretory organs.




The Biology of Glycoproteins


Book Description

This book is in many ways a sequel to The Biochemistry ojGlycoproteins and Proteoglycans. The enormous recent progress in understanding the biological roles of glycoproteins has prompted the present volume. The reasons for studying glycoproteins have multiplied, and in the present volume the roles played by glycoproteins are explored in a variety of biological situations. The first two chapters describe molecules involved in cell-substratum and cell-cell interactions in a broad sense, and also focus on recent progress in identifying specific attachment molecules. Our understanding of how normal processes, such as cellular differentiation and tissue organization, are regulated is dependent on understanding how cells interact with the extracellular matrix. When these processes go awry the consequences can be tragic, for example, when manifest as birth de fects and cancer. Our ability to devise appropriate therapies is in many cases limited by our understanding of such cell-matrix interactions. The third chapter explores the roles by glycoproteins during early mammalian development. The carbohydrate portions c1early play very important roles in presenting information during early embryogenesis, and an unusual tumor stern cell, the embryonal carcinoma, looks very promising in pro viding an experimental system for understanding how the expression of these complex carbohydrate determinants is regulated. The next three chapters explore the biology of glycoproteins in distinct situations: in the immune system, in the nervous system, and during erythropoiesis.




The Epigenetic Nature of Early Chordate Development


Book Description

This volume summarises our present knowledge of inductive interaction during early development of various groups of chordates. Embryonic development is mainly epigenetic, that is, each embryo arises through gradual organisation and emergence of its constituent parts and not by the unfolding of preformed structures. Development as far as the full development of the 'body plan' in the embryo is described. At the beginning of development, there is only very restricted spatial diversity, but as development proceeds the interaction of the different parts leads to ever-increasing spatial complexity of the developing embryo. Interaction starts between the different cell organelles of the oocyte and the, spermatozoon; it continues without interruption between the different parts of the very early embryo and also between the different tissues and organ anlagen of the developing embryo. The new hypothesis as to the nature of the inductive interaction, which is postulated here, is in good agreement with the experimental evidence presented and opens new possibilities for fruitful research into this basic concept of embryonic development.




Biology of Fertilization V1


Book Description

Biology of Fertilization, Volume 1: Model Systems and Oogenesis is the first in a three-volume series that gathers various lines of research about reproduction in general and fertilization in particular. Knowledge about cell biology, immunobiology, biochemistry, biophysics, and molecular genetics has progressed significantly beyond our understanding of some aspects of fertilization. Components of these constitute ""model systems."" The present volume includes reviews of such systems, some relatively simple model systems in lower organisms, sex-determining mechanisms, and oogenesis. The book contains 12 chapters organized into two sections. Section I includes studies on evolution, reproductive success, and immortality of the germ line; the structures and mechanisms involved in fertilization problems; and fertilization in Paramecium. Section II on oogenesis includes studies on gamete differentiation; sex-determining role of the H-Y antigen in mammals and non-mammals; the mechanism of starfish oocyte maturation; meiotic arrest in animal oocytes; and the mitotic and meiotic aspects of the mammalian germ cell life cycle.




Gene Activity in Early Development


Book Description

The new third edition of Gene Activity in Early Development reflects the ten years of technological progress since the last edition. Providing a unique blend of classical and molecular knowledge, it discusses all major embryonic systems from both a comparative and mechanistic point of view. In deriving overall interpretations of developmental phenomena, it brings into play all the disparate forms of evidence, including genetic, molecular, and cytological.**This book is written for any serious student or scholar entering the field, whether his or her background is in genetics, molecular biology, or embryology.




Plant-Microbe Interactions


Book Description

Recent years have seen tremendous progress in unraveling the molecular basis of different plant-microbe interactions. Knowledge has accumulated on the mecha nisms of the microbial infection of plants, which can lead to either disease or resistance. The mechanisms developed by plants to interact with microbes, whether viruses, bacteria, or fungi, involve events that can lead to symbiotic association or to disease or tumor formation. Cell death caused by pathogen infection has been of great interest for many years because of its association with plant resistance. There appear to be two types of plant cell death associated with pathogen infection, a rapid hypersensitive cell death localized at the site of infection during an incompatible interaction between a resistant plant and an avirulent pathogen, and a slow, normosensitive plant cell death that spreads beyond the site of infection during some compatible interactions involving a susceptible plant and a virulent, necrogenic pathogen. Plants possess a number of defense mechanisms against infection, such as (i) production of phytoalexin, (ii) formation of hydrolases, (iii) accumulation of hydroxyproline-rich glycoprotein and lignin deposition, (iv) production of pathogen-related proteins, (v) produc tion of oligosaccharides, jasmonic acid, and various other phenolic substances, and (vi) production of toxin-metabolizing enzymes. Based on these observations, insertion of a single suitable gene in a particular plant has yielded promising results in imparting resistance against specific infection or disease. It appears that a signal received after microbe infection triggers different signal transduction pathways.




A Comparative Overview of Mammalian Fertilization


Book Description

In 1964, the Fertilization and Gamete Physiology Research Training Program (FERGAP) was established at the Marine Biological Laboratories, Woods Hole, Massachusetts. Over the course of the next 12 years, under the directorship of Dr. Charles B. Metz, FERGAP brought together, trained, and inspired a generation of students in reproductive biology from all over the world. As students of C. B. Metz and as FERGAP trainees, we would like to dedicate this collected work on comparative mammalian fertilization to our teacher and mentor, Dr. Charles B. Metz. Like a number of authors contributing to this volume, we have been struck by the significant impact that C. B. Metz and FERGAP had on the development of students of reproductive biology. Applying both the classical and molecular techniques of cell biology and immunology to problems of gamete biology, Dr. Metz emphasized a comparative and analytical approach that was reflected in his own research on fertilization in Paramecia, sea urchins, frogs, and mammals. It is hoped that this volume will serve to stimulate students to discover the myriad of fascinating research problems in gamete and reproductive biology. Bonnie S. Dunbar Michael G. O'Rand Houston, Texas Chapel Hill, North Carolina ix Contents Part I COMPARATIVE OVERVIEW OF MAMMALIAN GAMETES The Coevolution of Mammalian Gametes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 J. Michael Bedford I. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. Gamete Design . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.1. Monotremes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 . . . . . . . . . . . . . . 2.2. Marsupials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 . . . . . . . . . . . . . . . 2.3. Eutherians . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. Gamete Maturation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 . . . . . . . . . . . . . . . 3 .1. Oocyte Maturation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 . . . . . . . . . . . . . 3.2. Sperm Maturation in the Male . . . . . . . . . . . . . . . . . . . . . . . 15 . . . . . . . . . .




Current Developments in Biological Nitrogen Fixation


Book Description

This volume discusses the most recent advances in biological nitrogen fixation, with chapters written by experts on the ecology, physiology, biochemistry and genetics of biological nitrogen fixation.




Recent Books