The Denervated Muscle


Book Description




Electrical Stimulation and Neuromuscular Disorders


Book Description

In many cases of neuromuscular disorders the physician is faced with a complete lack of therapeutic approaches. This helplessness places the doctor in a position of conflict between his desire to help and his awareness that there is no treatment. In this situation it is tempting to indiscriminately use any procedure that avoids an admission of medical helplessness while satisfying the patient's demand for treatment. Electrical interventions are often used to avoid this situation. Due to the random use of therapeutic approaches it is not known what really happens. Presumptions and biased empirical observations have led to the exten sive use of different forms of electrical stimulation regimes in neuromuscular diseases. Due to this unsatisfactory situation it is necessary to know more about appropriate methods that are being used in particular disorders. The search for a better understanding of nerve-muscle interaction has shown that certain activity patterns can influence muscle. These experi mental results provide a rational basis for a possible therapeutic use of electrical stimulation of nerve and muscle. Previously most research has been conducted in normal tissue, and little is known regarding the re sponses of diseased muscle. In an interdisciplinary approach to this, it is our intention to present the current knowledge about basic principles of electrical stimulation in normal muscle. Before electrical stimulation can be accepted as a therapeutic tool, we felt it necessary to summarize the effects of activity in normal and diseased muscle and nerve.




Disorders of Voluntary Muscle


Book Description

Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.




Pathophysiology and Surgical Treatment of Unilateral Vocal Fold Paralysis


Book Description

All laryngologists, especially general ENT doctors who see patients with paralytic dysphonia, as well as speech pathologists, will benefit from this book’s coverage of many basic and clinical aspects of reinnervation in retrieving patients’ normal voices. Phonosurgical treatment for paralytic dysphonia was first established in the late 1970s in the form of arytenoid adduction and medialization laryngoplasty. It made possible the improvement of patients’ post-op voices, but it was difficult to regain patients’ own pre-paralysis voices. It has recently been established that immediate reconstruction of the recurrent laryngeal nerve during tumor extirpation is effective in recovery of their original voices in patients with unilateral vocal fold paralysis (VFP). The activity of the thyroarytenoid muscle is needed to recover normal voices. Nerve–muscle pedicle (NMP) flap implantation with a refined technique to the thyroarytenoid muscle is a novel method for that purpose. NMP flap implantation combined with arytenoid adduction was applied by the author to patients suffering from dysphonia and most patients did recover their nearly normal voices after surgery. This book provides readers with (1) what the currently prevalent surgical procedures are, (2) unsatisfactory results of these conventional procedures, (3) results of immediate recurrent laryngeal nerve reconstruction during tumor extirpation, (4) the outcome of delayed reinnervation combined with arytenoid adduction in patients with VFP and further, (5) the scientific basis that explains the reasons why the author’s method is effective in the recovery of patients’ own pre-paralysis, normal voices.




Electromyography and Neuromuscular Disorders E-Book


Book Description

Diagnose neuromuscular disorders more quickly and accurately with Electromyography and Neuromuscular Disorders: Clinical-Electrophysiologic Correlations, 3rd Edition! State-of-the-art guidance helps you correlate electromyographic and clinical findings and use the latest EMG techniques to their fullest potential. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Successfully correlate electrodiagnostic findings with key clinical findings for more confident diagnoses. Clearly see how to apply what you’ve learned with abundant case studies throughout the book. Obtain relevant clinical guidance quickly and easily with an accessible, easy-to-read writing style that’s both comprehensive and easy to understand. Ensure correct EMG needle placement and avoid neurovascular injuries by referring to more than 65 detailed, cross-sectional anatomy drawings. Diagnose many newly defined genetic neuromuscular conditions based on their electrodiagnostic presentation. Stay up to date with must-know information on iatrogenic complications of electrodiagnostic studies. Visualize key concepts more easily with a brand-new full-color design, new artwork, and new photographs. Access Electromyography and Neuromuscular Disorders online, fully searchable, at www.expertconsult.com, along with more than 70 videos that allow you to see and hear the EMG waveforms discussed in the text, as well as a convenient "test yourself" module.




Targeted Muscle Reinnervation


Book Description

Implement TMR with Your Patients and Improve Their Quality of LifeDeveloped by Dr. Todd A. Kuiken and Dr. Gregory A. Dumanian, targeted muscle reinnervation (TMR) is a new approach to accessing motor control signals from peripheral nerves after amputation and providing sensory feedback to prosthesis users. This practical approach has many advantage




Muscle Atrophy


Book Description

The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.




Nerve-Muscle Interaction


Book Description

In the second century, Galen recognized that nerve and muscle were functionally inseparable since contraction of muscle occurred only if the nerves supplying that muscle were intact. He therefore concluded that the shortening of a muscle was controlled by the central nervous sytem while the extension of a muscle could occur in the absence of innervation. Nerves, he thought, were the means of transport for animal spirits to the muscles; the way in which animal spirits may bring about contraction dominated the study of muscle physiology from that time until the historical discovery of Galvani that muscle could be stimulated electrically and that nerve and muscle were themselves a source of electrical energy. It is now well known that nerves conduct electrically and that transmission from nerve to striated muscle is mediated by the chemical which is liberated from nerve terminals onto the muscle membrane. In vertebrates this chemical is acetylcholine (ACh). Thus the concept of spirits that are released from nerves and control muscle contraction directly, is no longer tenable. Nevertheless the concept of 'substances' transported down nerv~s which directly control many aspects of muscle has not been abandoned, and has in fact been frequently reinvoked to account for the long-term regula tion of many characteristics of muscle (see review by Gutmann, 1976) and for the maintenance of its structural integrity.




Muscle Biopsy


Book Description




Muscle Injuries in Sport Athletes


Book Description

This book attempts to provide a comprehensive look at all of the pathologies of muscles that are likely to be encountered in treating sports-related injuries. Its purpose is to give the practitioner a guide for identifying injuries and choosing the best therapeutic strategy. The first part presents the consensus view of current knowledge: the physiology of lesions and their prognosis as well as their anatomy, clinical imaging, and treatment. Then each of the muscles is described in turn, with a review of anatomy, clinical examination, the results of imaging, and therapeutic choices for acute and chronic injuries. A major section is dedicated to imaging, with the emphasis on which diagnostic methods are best for specific injuries and how to use diagnostic imaging to determine the most suitable therapeutic strategies. Special care has been taken to provide high-quality illustrations that clearly show how to identify the lesion of the damaged muscle. A wealth of illustrations, many in color, are included. Finally, the book concludes with some clinical cases and technical notes relevant to treatment of sports-related muscle injuries.