The Natural History of Inbreeding and Outbreeding


Book Description

Inbreeding, the mating of close kin, and outbreeding, the mating of distant relatives or unrelated organisms, have long been important subjects to evolutionary biologists. Inbreeding reduces genetic diversity in a population, increasing the likelihood that genetic defects will become widespread and deprive a population of the diversity it may need to cope with its environment. Most plants and animals have evolved behavioral and morphological mechanisms to avoid inbreeding. However, today many endangered species exist only in small, very isolated populations where inbreeding is unavoidable, so it has become a concern for conservationists. In this volume, twenty-six experts in evolution, behavior, and genetics examine the causes and consequences of inbreeding. The authors ask whether inbreeding is as problematic as biologists have thought, under what ecological conditions inbreeding occurs, and whether organisms that inbreed have mechanisms to dampen the anticipated problems of reduced genetic variation. The studies, including theoretical and empirical work on wild and captive populations, demonstrate that many plants and animals inbreed to a greater extent than biologists have thought, with variable effects on individual fitness. Graduate students and researchers in evolutionary biology, animal behavior, ecology, and conservation biology will welcome this wide-ranging collection.




Inbreeding, Incest, and the Incest Taboo


Book Description

Why is incest widely prohibited? Why does the scope of the prohibition vary from society to society? Why does incest occur despite the prohibition? What are the consequences? To reexamine these questions, this book brings together contributions from the fields of genetics, behavioral biology, primatology, biological and social anthropology, philosophy, and psychiatry.




The Theory of Inbreeding


Book Description

Segregating inbreed lines; Progress towards homozygosity; Various systems of inbreeding; Junctions; Appendix.




Conservation Genetics


Book Description

It follows naturally from the widely accepted Darwinian dictum that failures of populations or of species to adapt and to evolve under changing environments will result in their extinction. Population geneti cists have proclaimed a centerstage role in developing conservation biology theory and applications. However, we must critically reexamine what we know and how we can make rational contributions. We ask: Is genetic variation really important for the persistence of species? Has any species become extinct because it ran out of genetic variation or because of inbreeding depression? Are demographic and environmental stochas ticity by far more important for the fate of a population or species than genetic stochasticity (genetic drift and inbreeding)? Is there more to genetics than being a tool for assessing reproductive units and migration rates? Does conventional wisdom on inbreeding and "magic numbers" or rules of thumb on critical effective population sizes (MVP estimators) reflect any useful guidelines in conservation biology? What messages or guidelines from genetics can we reliably provide to those that work with conservation in practice? Is empirical work on numerous threatened habitats and taxa gathering population genetic information that we can use to test these guidelines? These and other questions were raised in the invitation to a symposium on conservation genetics held in May 1993 in pleasant surroundings at an old manor house in southern Jutland, Denmark.




The Evaluation of Forensic DNA Evidence


Book Description

In 1992 the National Research Council issued DNA Technology in Forensic Science, a book that documented the state of the art in this emerging field. Recently, this volume was brought to worldwide attention in the murder trial of celebrity O. J. Simpson. The Evaluation of Forensic DNA Evidence reports on developments in population genetics and statistics since the original volume was published. The committee comments on statements in the original book that proved controversial or that have been misapplied in the courts. This volume offers recommendations for handling DNA samples, performing calculations, and other aspects of using DNA as a forensic toolâ€"modifying some recommendations presented in the 1992 volume. The update addresses two major areas: Determination of DNA profiles. The committee considers how laboratory errors (particularly false matches) can arise, how errors might be reduced, and how to take into account the fact that the error rate can never be reduced to zero. Interpretation of a finding that the DNA profile of a suspect or victim matches the evidence DNA. The committee addresses controversies in population genetics, exploring the problems that arise from the mixture of groups and subgroups in the American population and how this substructure can be accounted for in calculating frequencies. This volume examines statistical issues in interpreting frequencies as probabilities, including adjustments when a suspect is found through a database search. The committee includes a detailed discussion of what its recommendations would mean in the courtroom, with numerous case citations. By resolving several remaining issues in the evaluation of this increasingly important area of forensic evidence, this technical update will be important to forensic scientists and population geneticistsâ€"and helpful to attorneys, judges, and others who need to understand DNA and the law. Anyone working in laboratories and in the courts or anyone studying this issue should own this book.




Analysis of Complex Disease Association Studies


Book Description

According to the National Institute of Health, a genome-wide association study is defined as any study of genetic variation across the entire human genome that is designed to identify genetic associations with observable traits (such as blood pressure or weight), or the presence or absence of a disease or condition. Whole genome information, when combined with clinical and other phenotype data, offers the potential for increased understanding of basic biological processes affecting human health, improvement in the prediction of disease and patient care, and ultimately the realization of the promise of personalized medicine. In addition, rapid advances in understanding the patterns of human genetic variation and maturing high-throughput, cost-effective methods for genotyping are providing powerful research tools for identifying genetic variants that contribute to health and disease. This burgeoning science merges the principles of statistics and genetics studies to make sense of the vast amounts of information available with the mapping of genomes. In order to make the most of the information available, statistical tools must be tailored and translated for the analytical issues which are original to large-scale association studies. Analysis of Complex Disease Association Studies will provide researchers with advanced biological knowledge who are entering the field of genome-wide association studies with the groundwork to apply statistical analysis tools appropriately and effectively. With the use of consistent examples throughout the work, chapters will provide readers with best practice for getting started (design), analyzing, and interpreting data according to their research interests. Frequently used tests will be highlighted and a critical analysis of the advantages and disadvantage complimented by case studies for each will provide readers with the information they need to make the right choice for their research. Additional tools including links to analysis tools, tutorials, and references will be available electronically to ensure the latest information is available. - Easy access to key information including advantages and disadvantage of tests for particular applications, identification of databases, languages and their capabilities, data management risks, frequently used tests - Extensive list of references including links to tutorial websites - Case studies and Tips and Tricks




Racehorse Breeding Theories


Book Description

"Here, in one volume, is a wide and varied assessment of the major breeding systems or theories, as well as the history and background of each. The writers give the reader all the necessary information they need to implement the theory and make it part of a breeding program. They also verify the relative scientific validity of the theories and various approaches to breeding" -- publisher website (April 2007).




Introduction to Conservation Genetics


Book Description

This impressive author team brings the wealth of advances in conservation genetics into the new edition of this introductory text, including new chapters on population genomics and genetic issues in introduced and invasive species. They continue the strong learning features for students - main points in the margin, chapter summaries, vital support with the mathematics, and further reading - and now guide the reader to software and databases. Many new references reflect the expansion of this field. With examples from mammals, birds ...




Encyclopedia of Rose Science


Book Description

The Encyclopedia of Rose Science brings together a wealth of information on the rose, long treasured for its captivating perfumes and splendid colors. Now, more than ever, science plays a central place in the production of this flower at the center of one of the world's biggest floricultural industries. A team of internationally renowned experts has contributed scores of articles, from the history of rose cultivation to discoveries in rose genetics. For researchers and students, as well as commercial rose growers and breeders, the Encyclopedia of Rose Science is an invaluable reference. The Encyclopedia of Rose Science is available online on ScienceDirect. The print edition price for this reference work does not include online access. For more information on pricing for access to the online edition, please review our Licensing Options. The richness and authority of Elsevier reference works is now lent valuable functionality and accessibility through the online launch of Elsevier Reference Works on ScienceDirect. Features: Extensive browsing and searching across subject, thematic, alphabetical, author and cited author indexes - as applicable to the work Basic and advanced search functionality within volumes, parts of volumes, or across the whole work Ability to build, save and re-run searches as well as combine saved searches Internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy All articles are available as full-text HTML files, and as PDF files that can be viewed, downloaded or printed out in their original print format A dedicated Reference Works navigation tab and homepage on ScienceDirect to enable easy linking from your OPAC or library website For more information about the Elsevier Reference Works on ScienceDirect Program, please visit: http://www.info.sciencedirect.com/reference_works. Presents complete, up-to-date information on over 35 subject areas of major importance to rose scientists Encyclopedic format provides for concise, readable entires, easy searches, and extensive cross-references Incorporates MODERN ROSES XI, published by the American Rose Society as International Cultivar Registration Authority for Roses, the most comprehensive list of roses of historical and botanical importance! High quality full-color production, with many figures and tables




Population Genetics and Microevolutionary Theory


Book Description

The advances made possible by the development of molecular techniques have in recent years revolutionized quantitative genetics and its relevance for population genetics. Population Genetics and Microevolutionary Theory takes a modern approach to population genetics, incorporating modern molecular biology, species-level evolutionary biology, and a thorough acknowledgment of quantitative genetics as the theoretical basis for population genetics. Logically organized into three main sections on population structure and history, genotype-phenotype interactions, and selection/adaptation Extensive use of real examples to illustrate concepts Written in a clear and accessible manner and devoid of complex mathematical equations Includes the author's introduction to background material as well as a conclusion for a handy overview of the field and its modern applications Each chapter ends with a set of review questions and answers Offers helpful general references and Internet links