The Use of Rapid Syphilis Tests


Book Description

This manual provides a general overview on the use of rapid syphilis tests, their purchase, transport and storage.--Publisher's description.













Screening Donated Blood for Transfusion-transmissible Infections


Book Description

"Blood transfusion is a life-saving intervention that has an essential role in patient management within health care systems. All Member States of the World Health Organization (WHO) endorsed World Health Assembly resolutions WHA28.72 (1) in 1975 and WHA58.13 (2) in 2005. These commit them to the provision of adequate supplies of safe blood and blood products that are accessible to all patients who require transfusion either to save their lives or promote their continuing or improving health." --Preface.




Innovative Testing Strategies for the Diagnosis of Syphilis


Book Description

Traditional serological syphilis testing in the US currently includes screening with a nontreponemal assay that detects antibodies to lipoidal material released into the blood from host cells damaged by Treponema pallidum as well as lipids on the surface of nonspecific treponemes itself. Reactive nontreponemal tests are subsequently confirmed with a test that detects antibody specific for T. pallidum (termed "treponemal"). It has been suggested that this traditional serological algorithm could be reversed so that screening begins with a treponemal test, such as an enzyme immunoassay (EIA), and if reactive, infection would be confirmed with a nontreponemal test. In cases of discordance between the screening treponemal test and the confirmatory non-treponemal test, the CDC suggests that a second treponemal test (such as a TPPA) could be utilized to serve as a supplemental test. The reverse sequence testing algorithm offers several advantages over the traditional algorithm for laboratories. Screening with an immunoassay (IA) (1) allows for the use of automation, thus potentially increasing laboratory efficiency; (2) provides objective instead of subjective results; (3) reduces the amount of manual manipulation that is involved with nontreponemal assays. However, the algorithm is not without issues. Perhaps greatest amongst them is that such tests will be reactive in cases where the patient has previously been treated for syphilis. This may be particularly problematic in a setting with a high prevalence of syphilis where many patients being tested may have had a previous case of the disease. This dissertation is formatted as three individual, self-contained reports of research investigations with an overall introduction and conclusion. Chapter 2 reports on the performance of a reverse sequence algorithm in San Francisco and shows that this algorithm would cause a large amount of additional work for the laboratory. Chapter 3 describes a reduction in the number of supplemental treponemal tests that needs to be run if EIA signal-to-cutoff ratios were considered as part of the algorithm. Chapter 4 describes how a rapid syphilis test could potentially replace the TPPA as the second supplemental test in the reverse sequence algorithm, thus decreasing the turnaround time to report positive syphilis results.







CDC Yellow Book 2018: Health Information for International Travel


Book Description

THE ESSENTIAL WORK IN TRAVEL MEDICINE -- NOW COMPLETELY UPDATED FOR 2018 As unprecedented numbers of travelers cross international borders each day, the need for up-to-date, practical information about the health challenges posed by travel has never been greater. For both international travelers and the health professionals who care for them, the CDC Yellow Book 2018: Health Information for International Travel is the definitive guide to staying safe and healthy anywhere in the world. The fully revised and updated 2018 edition codifies the U.S. government's most current health guidelines and information for international travelers, including pretravel vaccine recommendations, destination-specific health advice, and easy-to-reference maps, tables, and charts. The 2018 Yellow Book also addresses the needs of specific types of travelers, with dedicated sections on: · Precautions for pregnant travelers, immunocompromised travelers, and travelers with disabilities · Special considerations for newly arrived adoptees, immigrants, and refugees · Practical tips for last-minute or resource-limited travelers · Advice for air crews, humanitarian workers, missionaries, and others who provide care and support overseas Authored by a team of the world's most esteemed travel medicine experts, the Yellow Book is an essential resource for travelers -- and the clinicians overseeing their care -- at home and abroad.




Sexually Transmitted Diseases


Book Description




Revolutionizing Tropical Medicine


Book Description

A comprehensive resource describing innovative technologies and digital health tools that can revolutionize the delivery of health care in low- to middle-income countries, particularly in remote rural impoverished communities Revolutionizing Tropical Medicine offers an up-to-date guide for healthcare and other professionals working in low-resource countries where access to health care facilities for diagnosis and treatment is challenging. Rather than suggesting the expensive solution of building new bricks and mortar clinics and hospitals and increasing the number of doctors and nurses in these deprived areas, the authors propose a complete change of mindset. They outline a number of ideas for improving healthcare including rapid diagnostic testing for infectious and non-infectious diseases at a point-of-care facility, together with low cost portable imaging devices. In addition, the authors recommend a change in the way in which health care is delivered. This approach requires task-shifting within the healthcare provision system so that nurses, laboratory technicians, pharmacists and others are trained in the newly available technologies, thus enabling faster and more appropriate triage for people requiring medical treatment. This text: Describes the current burden of communicable and non-communicable diseases in low- to middle-income countries throughout the world Describes the major advances in healthcare outcomes in low-to middle-income countries derived from implementation of the United Nations/World Health Organisation’s 2000 Millennium Development Goals Provides a review of inexpensive rapid diagnostic point-of-care tests for infectious diseases in low-resource countries, particularly for people living in remote rural areas Provides a review of other rapid point-of-care services for assessing hematological function, biochemical function, renal function, hepatic function and status including hepatitis, acid-base balance, sickle cell disease, severe acute malnutrition and spirometry Explores the use of low-cost portable imaging devices for use in remote rural areas including a novel method of examining the optic fundus using a smartphone and the extensive value of portable ultrasound scanning when x-ray facilities are not available Describes the use of telemedicine in the clinical management of both children and adults in remote rural settings Looks to the future of clinical management in remote impoverished rural settings using nucleic acid identification of pathogens, the use of nanoparticles for water purification, the use of drones, the use of pulse oximetry and the use of near-infrared spectroscopy Finally, it assesses the potential for future healthcare improvement in impoverished areas and how the United Nations/World Health Organization 2015 Sustainable Development Goals are approaching this. Written for physicians, infectious disease specialists, pathologists, radiologists, nurses, pharmacists and other health care workers, as well as government healthcare managers, Revolutionizing Tropical Medicine is a new up-to-date essential and realistic guide to treating and diagnosing patients in low-resource tropical countries based on new technologies.