Author : Lawrence M. Friedman
Publisher : Springer Science & Business Media
Page : 384 pages
File Size : 30,80 MB
Release : 1998
Category : Medical
ISBN : 9780387985862
This classic reference, now updated with the newest applications and results, addresses the fundamentals of such trials based on sound scientific methodology, statistical principles, and years of accumulated experience by the three authors.
Author : Duolao Wang
Publisher : Remedica
Page : 497 pages
File Size : 30,81 MB
Release : 2006
Category : Medical
ISBN : 1901346722
This book explains statistics specifically for a medically literate audience. Readers gain not only an understanding of the basics of medical statistics, but also a critical insight into how to review and evaluate clinical trial evidence.
Author : V B Johnson
Publisher : Elsevier
Page : 817 pages
File Size : 18,41 MB
Release : 2001-10-10
Category : Technology & Engineering
ISBN : 0080546153
Laxton's gives you access to the most reliable and current data. All 250,000 price elements have been individually checked and updated for the 2002 edition so that your estimates are always accurate and cost competitive. Laxton's makes analytical estimating simple and straightforward by displaying a complete breakdown for all measured items under 10 separate headings, all on a single page. This shows you a complete price build-up at a glance - and gives you the option to make price adjustments wherever necessary. You can find the sections you need quickly and easily, via the special marker system on the front cover and page edges. The free CD with this price book contains Masterbill's ESTIMATOR software and fully resourced data on all the price elements in Laxtons. Not only does the CD offer fast and efficient pricing at the touch of a button, it gives details of all the resources required to do the job. Laxton's approximate estimating section gives all in pricing for quick reference on the cost of composite items such as floors helping you calculate the cost implications of using plywood sheeting rather than softwood boarding, for example. Laxton's Basic Price section gives you a quick price on hundreds of items - from concrete work to roofing materials - to save you going through hundreds of lists from suppliers, manufacturers and building merchants. Laxton's Brand and Trade Names section lists over 12,000 brands and trade names and company addresses to help you locate specific items. Latest wage rates, fees and allowances All 250,000 price elements checked and updated
Author : R. Brian Haynes
Publisher : Lippincott Williams & Wilkins
Page : 516 pages
File Size : 35,59 MB
Release : 2012-03-29
Category : Medical
ISBN : 1451178794
The Third Edition of this popular text focuses on clinical-practice research methods. It is written by clinicians with experience in generating and answering researchable questions about real-world clinical practice and health care—the prevention, treatment, diagnosis, prognosis, and causes of diseases, the measurement of quality of life, and the effects of innovations in health services. The book has a problem-oriented and protocol-based approach and is written at an introductory level, emphasizing key principles and their applications. A bound-in CD-ROM contains the full text of the book to help the reader locate needed information.
Author : Shein-Chung Chow
Publisher : John Wiley & Sons
Page : 754 pages
File Size : 49,54 MB
Release : 2008-12-04
Category : Mathematics
ISBN : 0471473294
Praise for the First Edition of Design and Analysis of Clinical Trials "An excellent book, providing a discussion of the clinical trial process from designing the study through analyzing the data, and to regulatory requirement . . . could easily be used as a classroom text to understand the process in the new drug development area." –Statistical Methods in Medicine A complete and balanced presentation now revised, updated, and expanded As the field of research possibilities expands, the need for a working understanding of how to carry out clinical trials only increases. New developments in the theory and practice of clinical research include a growing body of literature on the subject, new technologies and methodologies, and new guidelines from the International Conference on Harmonization (ICH). Design and Analysis of Clinical Trials, Second Edition provides both a comprehensive, unified presentation of principles and methodologies for various clinical trials, and a well-balanced summary of current regulatory requirements. This unique resource bridges the gap between clinical and statistical disciplines, covering both fields in a lucid and accessible manner. Thoroughly updated from its first edition, the Second Edition of Design and Analysis of Clinical Trials features new topics such as: Clinical trials and regulations, especially those of the ICH Clinical significance, reproducibility, and generalizability Goals of clinical trials and target population New study designs and trial types Sample size determination on equivalence and noninferiority trials, as well as comparing variabilities Also, three entirely new chapters cover: Designs for cancer clinical trials Preparation and implementation of a clinical protocol Data management of a clinical trial Written with the practitioner in mind, the presentation assumes only a minimal mathematical and statistical background for its reader. Instead, the writing emphasizes real-life examples and illustrations from clinical case studies, as well as numerous references-280 of them new to the Second Edition-to the literature. Design and Analysis of Clinical Trials, Second Edition will benefit academic, pharmaceutical, medical, and regulatory scientists/researchers, statisticians, and graduate-level students in these areas by serving as a useful, thorough reference source for clinical research.
Author : Maurizio Delvecchio
Publisher : Frontiers Media SA
Page : 139 pages
File Size : 16,75 MB
Release : 2023-06-01
Category : Medical
ISBN : 2832524702
Author : Stephen B. Hulley
Publisher : Lippincott Williams & Wilkins
Page : 388 pages
File Size : 43,40 MB
Release : 2007
Category : Medical
ISBN : 9780781782104
This third edition sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This edition incorporates current research methodology and offers an updated syllabus for conducting a clinical research workshop.
Author : Yuan-Shun Dai
Publisher : Nova Publishers
Page : 336 pages
File Size : 14,2 MB
Release : 2007
Category : Computers
ISBN : 9781600212024
The field of parallel and distributed computing is undergoing changes at a breathtaking pace. Networked computers are now omnipresent in virtually every application, from games to sophisticated space missions. The increasing complexity, heterogeneity, largeness, and dynamism of the emerging pervasive environments and associated applications are challenging the advancement of the parallel and distributed computing paradigm. Many novel infrastructures have been or are being created to provide the necessary computational fabric for realising parallel and distributed applications from diverse domains. New models and tools are also being proposed to evaluate and predict the quality of these complicated parallel and distributed systems. Current and recent past efforts, made to provide the infrastructures and models for such applications, have addressed many underlying complex problems and have thus resulted in new tools and paradigms for effectively realising parallel and distributed systems. This book showcases these novel tools and approaches with inputs from relevant experts.
Author : Neil J. Salkind
Publisher : SAGE
Page : 1779 pages
File Size : 10,85 MB
Release : 2010-06-22
Category : Philosophy
ISBN : 1412961270
"Comprising more than 500 entries, the Encyclopedia of Research Design explains how to make decisions about research design, undertake research projects in an ethical manner, interpret and draw valid inferences from data, and evaluate experiment design strategies and results. Two additional features carry this encyclopedia far above other works in the field: bibliographic entries devoted to significant articles in the history of research design and reviews of contemporary tools, such as software and statistical procedures, used to analyze results. It covers the spectrum of research design strategies, from material presented in introductory classes to topics necessary in graduate research; it addresses cross- and multidisciplinary research needs, with many examples drawn from the social and behavioral sciences, neurosciences, and biomedical and life sciences; it provides summaries of advantages and disadvantages of often-used strategies; and it uses hundreds of sample tables, figures, and equations based on real-life cases."--Publisher's description.
Author : Sandeep Menon
Publisher : SAS Institute
Page : 496 pages
File Size : 46,80 MB
Release : 2015-12-09
Category : Computers
ISBN : 1629600822
Get the tools you need to use SAS® in clinical trial design! Unique and multifaceted, Modern Approaches to Clinical Trials Using SAS: Classical, Adaptive, and Bayesian Methods, edited by Sandeep M. Menon and Richard C. Zink, thoroughly covers several domains of modern clinical trial design: classical, group sequential, adaptive, and Bayesian methods that are applicable to and widely used in various phases of pharmaceutical development. Written for biostatisticians, pharmacometricians, clinical developers, and statistical programmers involved in the design, analysis, and interpretation of clinical trials, as well as students in graduate and postgraduate programs in statistics or biostatistics, the book touches on a wide variety of topics, including dose-response and dose-escalation designs; sequential methods to stop trials early for overwhelming efficacy, safety, or futility; Bayesian designs that incorporate historical data; adaptive sample size re-estimation; adaptive randomization to allocate subjects to more effective treatments; and population enrichment designs. Methods are illustrated using clinical trials from diverse therapeutic areas, including dermatology, endocrinology, infectious disease, neurology, oncology, and rheumatology. Individual chapters are authored by renowned contributors, experts, and key opinion leaders from the pharmaceutical/medical device industry or academia. Numerous real-world examples and sample SAS code enable users to readily apply novel clinical trial design and analysis methodologies in practice.
