Biochemistry: A Very Short Introduction


Book Description

Very Short Introductions: Brilliant, Sharp, Inspiring From the simplest bacteria to humans, all living things are composed of cells of one type or another, all of which have fundamentally the same chemistry. This chemistry must provide mechanisms that allow cells to interact with the external world, a means to power the cell, machinery to carry out varied processes within the cell, a structure within which everything runs, and also governance through a web of interlocking chemical reactions. Biochemistry is the study of those reactions, the molecules that are created, manipulated, and destroyed as a result of them, and the massive macromolecules (such as DNA, cytoskeletons, proteins and carbohydrates) that form the chemical machinery and structures on which these biochemical reactions take place. It didn't take long for an understanding of the chemistry of life to turn into a desire to manipulate it. Drugs and therapies all aim to modify biochemical processes for good or ill: Penicillin, derived from mould, stops bacteria making their cell walls. Aspirin, with its origins in willow bark, inhibits enzymes involved in inflammatory responses. A few nanograms of botulinum toxin (botox), can kill by preventing the release of neurotransmitters from the ends of nerves and so leads to paralysis and death, or give a wrinkle free forehead (if administered in very tiny quantities).This Very Short Introduction discusses the key concepts of biochemistry, as well as the historical figures in the field and the molecules they studied, before considering the current science and innovations in the field, and the interaction between biochemistry, biotechnology, and synthetic biology. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.




A History of Biochemistry


Book Description




Selected Topics in the History of Biochemistry


Book Description

Selected Topics in the History of Biochemistry: Personal Recollections, I presents selected topics in the history of biochemistry based on the authors' personal recollections. These topics range from the isolation of Cori ester and the discovery of sugar nucleotides to the work of Frederick Gowland Hopkins (1861-1947). Ion-coupled membrane processes are also discussed, along with fructose and fructose-2,6-bisphosphateas well as lysosomes and glycogen. Comprised of 12 chapters, this volume begins with the discovery of Cori ester and the concept of phosphorolysis before turning to the discovery of sugar nucleotides and research on ion-coupled membrane processes. The reader is then introduced to studies of fructose, fructose-2,6-bisphosphate, lysosomes, and glycogen; the contributions of Frederick Gowland Hopkins in biochemistry; and a short autobiography of Juda Hirsch Quastel, with emphasis on his research work on the concept of active centers as a possible explanation of enzyme action and his investigation of the effects of malonic acid and substituted malonic acids on bacterial dehydrogenases. The remaining chapters focus on a biochemist's approach to autopharmacology; the early development of modern protein chemistry in Uppsala, Sweden; and the biographies of two Russian scientists, A. N. Bach and Sergei E. Severin. This monograph will be of interest to students, practitioners, and researchers in the field of biochemistry.




Selected Topics in the History of Biochemistry. Personal Recollections. Part III


Book Description

As in Volumes 35 and 36, the chapters in this new volume complement, with personal recollections, the History of Biochemistry that was covered in the Comprehensive Biochemistry Series, Volumes 30-33 by M. Florkin and Volume 34A by P. Laszlo. The biographical and autobiographical chapters will convey to the reader a lively, albeit at times subjective, view of the scientific and social environment in which the authors have worked, resulting in new concepts and theories on the biological sciences.







Biochemistry Collections


Book Description

This book, first published in 1982, offers an examination of the special nature of biochemistry collections. It focuses on the production, control, and use of the literature – diverse in nature, and analysed here by specialist contributors.




Early Adventures in Biochemistry


Book Description

The account in this inaugural volume of the series covers the period 1900 to 1960, but also outlines the principal developments in earlier centuries from which biochemistry emerged. Findings are considered in the light of present knowledge, rather than in a rigid historical framework.




The Oxford Companion to the History of Modern Science


Book Description

Containing 609 encyclopedic articles written by more than 200 prominent scholars, The Oxford Companion to the History of Modern Science presents an unparalleled history of the field invaluable to anyone with an interest in the technology, ideas, discoveries, and learned institutions that have shaped our world over the past five centuries. Focusing on the period from the Renaissance to the early twenty-first century, the articles cover all disciplines (Biology, Alchemy, Behaviorism), historical periods (the Scientific Revolution, World War II, the Cold War), concepts (Hypothesis, Space and Time, Ether), and methodologies and philosophies (Observation and Experiment, Darwinism). Coverage is international, tracing the spread of science from its traditional centers and explaining how the prevailing knowledge of non-Western societies has modified or contributed to the dominant global science as it is currently understood. Revealing the interplay between science and the wider culture, the Companion includes entries on topics such as minority groups, art, religion, and science's practical applications. One hundred biographies of the most iconic historic figures, chosen for their contributions to science and the interest of their lives, are also included. Above all The Oxford Companion to the History of Modern Science is a companion to world history: modern in coverage, generous in breadth, and cosmopolitan in scope. The volume's utility is enhanced by a thematic outline of the entire contents, a thorough system of cross-referencing, and a detailed index that enables the reader to follow a specific line of inquiry along various threads from multiple starting points. Each essay has numerous suggestions for further reading, all of which favor literature that is accessible to the general reader, and a bibliographical essay provides a general overview of the scholarship in the field. Lastly, as a contribution to the visual appeal of the Companion, over 100 black-and-white illustrations and an eight-page color section capture the eye and spark the imagination.




Biochemistry of Metabolism


Book Description

The Biochemistry of Plants: A Comprehensive Treatise, Volume 11: Biochemistry of Metabolism provides information pertinent to the chemical and biochemical aspects of metabolism. This book discusses the control mechanisms of metabolism. Organized into nine chapters, this volume begins with an overview of the history of biochemistry and discusses the developments in the kinetics of regulatory enzymes. This text then examines a theory that explains how subunit interactions modulate the rate of conversion of a substrate into a product. Other chapters consider some relation between cell-wall elongation and cell-wall charge density and explore the subcellular localization of the enzymes of glycolysis. This book discusses as well the regulation of glycolysis and the pentose phosphate pathway. The final chapter deals with the pathways of C1 metabolism that are of prime importance, as the synthesis of several cellular constituents depends directly or indirectly on folate metabolism. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.




Cathedrals of Science


Book Description

In Cathedrals of Science, Patrick Coffey describes how chemistry got its modern footing-how thirteen brilliant men and one woman struggled with the laws of the universe and with each other. They wanted to discover how the world worked, but they also wanted credit for making those discoveries, and their personalities often affected how that credit was assigned. Gilbert Lewis, for example, could be reclusive and resentful, and his enmity with Walther Nernst may have cost him the Nobel Prize; Irving Langmuir, gregarious and charming, "rediscovered" Lewis's theory of the chemical bond and received much of the credit for it. Langmuir's personality smoothed his path to the Nobel Prize over Lewis. Coffey deals with moral and societal issues as well. These same scientists were the first to be seen by their countries as military assets. Fritz Haber, dubbed the "father of chemical warfare," pioneered the use of poison gas in World War I-vividly described-and Glenn Seaborg and Harold Urey were leaders in World War II's Manhattan Project; Urey and Linus Pauling worked for nuclear disarmament after the war. Science was not always fair, and many were excluded. The Nazis pushed Jewish scientists like Haber from their posts in the 1930s. Anti-Semitism was also a force in American chemistry, and few women were allowed in; Pauling, for example, used his influence to cut off the funding and block the publications of his rival, Dorothy Wrinch. Cathedrals of Science paints a colorful portrait of the building of modern chemistry from the late 19th to the mid-20th century.