A Life of Ernest Starling


Book Description

Ernest Starling (1866-1927) was pre-eminent in the golden age of British Physiology. His name is usually associated with his "Law of the Heart,” but his discovery of secretin (the first hormone whose mode of action was explained) and his work on capillaries were more important contributions. He coined the word 'hormone' one hundred years ago. His analysis of capillary function demonstrated that equal and opposite forces move across the capillary wall--an outward (hydrostatic) force and an inward (osmotic) force derived from plasma proteins.




A Biographical History of Endocrinology


Book Description

Establishing endocrinology as a distinct medical specialty was no easy task. This engaging volume chronicles the journey through the stories of the men -and occasional women--who shaped the specialty through the ages. In 108 brief chapters, A Biographical History of Endocrinology illuminates the progress of endocrinology from Hippocrates to the modern day. The author highlights important leaders and their contributions to the field, including these early pioneers: Kos and Alexandria, and the first human anatomy Bartolomeo Eustachi and the adrenal gland Richard Lower and the pituitary gland Thomas Addison and adrenal insufficiency Franz Leydig and testosterone secreting cells Wiliam Stewart Halsted and surgery of the thyroid gland John J. Abel and isolation of hormones Hakaru Hashimoto and his disease Covering all the watershed moments in the history of the profession, the book identifies key figures whose contributions remain relevant today. Their fascinating stories of experiments and studies, advocacy and adversity, and exploring unknown territory will inspire the next generation of endocrinologists and satisfy every clinician who ever wondered "how did we get here?" This comprehensive yet concise biographical history of endocrinology will benefit not only practicing and prospective endocrinologists, but also other medical specialists and medical historians.




Essential Equations for Anaesthesia


Book Description

Covers all of the equations that candidates need to understand and be able to apply when sitting postgraduate anaesthetic examinations.




Unlikely Animals


Book Description

“This tragicomic novel is heartfelt, touching, and delightfully quirky. You’ll fall in love with the offbeat cast of characters (both living and dead) and find yourself rooting for them right through the last page.”—Good Housekeeping (Book Club pick) A lost young woman returns to small-town New Hampshire under the strangest of circumstances in this one-of-a-kind novel of life, death, and whatever comes after from the acclaimed author of Rabbit Cake. ONE OF THE BEST BOOKS OF THE YEAR: The Washington Post, Book Riot • Longlisted for the Joyce Carol Oates Prize It was a source of entertainment at Maple Street Cemetery. Both funny and sad, the kind of story we like best. Natural-born healer Emma Starling once had big plans for her life, but she’s lost her way. A medical school dropout, she’s come back to small-town Everton, New Hampshire, to care for her father, who is dying from a mysterious brain disease. Clive Starling has been hallucinating small animals, as well as having visions of the ghost of a long-dead naturalist, Ernest Harold Baynes, once known for letting wild animals live in his house. This ghost has been giving Clive some ideas on how to spend his final days. Emma arrives home knowing she must face her dad’s illness, her mom’s judgment, and her younger brother’s recent stint in rehab, but she’s unprepared to find that her former best friend from high school is missing, with no one bothering to look for her. The police say they don’t spend much time looking for drug addicts. Emma’s dad is the only one convinced the young woman might still be alive, and Emma is hopeful he could be right. Someone should look for her, at least. Emma isn’t really trying to be a hero, but somehow she and her father bring about just the kind of miracle the town needs. Set against the backdrop of a small town in the throes of a very real opioid crisis, Unlikely Animals is a tragicomic novel about familial expectations, imperfect friendships, and the possibility of resurrecting that which had been thought irrevocably lost.




Fluid Physiology


Book Description

This book is essential reading for medical or veterinary practitioners who need to understand the new fluid physiology and to apply it to the safe care of patients. The Starling principle is one of medicine’s most important concepts and originates from Ernest Starling’s laboratory research 120 years ago. However, inappropriate fluid therapy is now recognised as harming and even killing thousands of patients every year. In 2004, a landmark study was published which confirmed the hypotheses put forward by Sheldon Weinbaum and Charles Michel, among other physiologists, that, in most tissues and in most situations, capillaries filter fluid to the interstitium, but do not reabsorb it. This book draws together for the first time the evolving science of the steady-state Starling principle and the clinical evidence that reveals its applicability to safer patient care. It is a thorough re-appraisal of the basics of fluid therapy. The mantra of colloid boluses for plasma volume resuscitation and colloid-free isotonic salt solution for extracellular fluid volume does not explain observations from blinded clinical trials, and the expectation of benefit for resuscitation with colloids, particularly in respect of oedema, has not materialised. Now that there is consensus that colloid volume therapy should not be used in critically-ill patients, there is a pressing need for a new paradigm for fluid therapy. This book proposes an improved paradigm that takes into consideration the Starling principle, which has been neglected by clinicians and revised by physiologists in recent years. It retires the view of colloids as preferred plasma substitutes, and focuses instead on the central volume of distribution of an infused fluid, its rate of distribution to a peripheral volume, and its rate of excretion. In short, it emphasises volume kinetics.




Respiratory Physiology


Book Description

Present-day respiratory physiology stems largely from the explosion of ideas which took place during and after World War II. A number of the major players are still active, but the opportunity to prepare a personal history of this branch of medicine will soon be lost. In a sense then, this book offers an exceptional, even unique, opportunity. We are offered a first-hand chronicle of the advancements made in respiratory physiology in the course of this century by one of the principal figures in the field. The volume covers every aspect of the evolution of this important area of knowledge: morphology, gas exchange and blood flow, mechanics, control of ventillation, and comparative physiology. Some of the chapters are personal accounts of the development of respiratory physiology as observed by the author. It is hoped that what is lost in objectivity by this approach is more than made up by the captivating insights provided by the author into the process of scientific research and discovery.




The Cult of Youth


Book Description

The first account of anti-ageing and rejuvenation in modern Britain, exploring hormones, diet, electrotherapy, exercise and skin care.







Nathan Zuntz


Book Description

This book focuses on the life and work of Nathan Zuntz (1847-1920), a German physiologist, who made significant contributions to high altitude physiology and aviation medicine. He achieved fame for his invention of the Zuntz-Geppert respiratory apparatus in 1886 and the first treadmill (Laufband) in 1889. He also invented an X-ray apparatus to observe cardiac changes during exercise and constructed a climate chamber to study exercise under varying and sometimes extreme climates. - Focuses on Zuntz's contribution to high altitude physiology and aviation medicine




Narcocapitalism


Book Description

What do the invention of anaesthetics in the middle of the nineteenth century, the Nazis' use of cocaine, and the development of Prozac have in common? The answer is that they're all products of the same logic that defines our contemporary era: 'the age of anaesthesia'. Laurent de Sutter shows how large aspects of our lives are now characterised by the management of our emotions through drugs, ranging from the everyday use of sleeping pills to hard narcotics. Chemistry has become so much a part of us that we can’t even see how much it has changed us. In this era, being a subject doesn't simply mean being subjected to powers that decide our lives: it means that our very emotions have been outsourced to chemical stimulation. Yet we don't understand why the drugs that we take are unable to free us from fatigue and depression, and from the absence of desire that now characterizes our psychopolitical condition. We have forgotten what it means to be excited because our only excitement has become drug-induced. We have to abandon the narcotic stimulation that we’ve come to rely on and find a way back to the collective excitement that is narcocapitalism’s greatest fear.