Toll-Like Receptors (TLRs) and Innate Immunity


Book Description

Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.




DNA and RNA Modification Enzymes


Book Description

This volume is a timely and comprehensive description of the many facets of DNA and RNA modification-editing processes and to some extent repair mechanisms. Each chapter offers fundamental principles as well as up to date information on recent advances in the field (up to end 2008). They ended by a shortconclusion and future prospect' section and




Quantitative Microbial Risk Assessment


Book Description

Provides the latest QMRA methodologies to determine infection risk cause by either accidental microbial infections or deliberate infections caused by terrorism • Reviews the latest methodologies to quantify at every step of the microbial exposure pathways, from the first release of a pathogen to the actual human infection • Provides techniques on how to gather information, on how each microorganism moves through the environment, how to determine their survival rates on various media, and how people are exposed to the microorganism • Explains how QMRA can be used as a tool to measure the impact of interventions and identify the best policies and practices to protect public health and safety • Includes new information on genetic methods • Techniques use to develop risk models for drinking water, groundwater, recreational water, food and pathogens in the indoor environment




Leading-edge Messenger RNA Research Communications


Book Description

mRNA (messenger RNA) is the mediating template between DNA and proteins. The information from a particular gene is transferred from a strand of DNA by the construction of a complementary strand of RNA through a process known as transcription. Next three nucleotide segments of RNA, called tRNA (transfer RNA), which are attached to specific amino acids, match up with the template strand of mRNA to order the amino acids correctly. These amino acids are then bonded together to form a protein. This process, called translation occurs in the ribosome, which is composed of proteins and the third kind of RNA, rRNA (ribosomal RNA). This important book presents research from around the globe on this very active field of scientific investigation.




Drug Synergism and Dose-Effect Data Analysis


Book Description

Not since this author's bestselling Manual of Pharmacologic Calculation has there been an available reference for drug data analysis. Incorporating the most relevant parts of that work, Drug Synergism and Dose-Effect Data Analysis focuses on drug combinations and all the quantitative analyses needed to analyze drug combination dose-effect data and to design experiments with two or more compounds. The book contains the statistical methods, the theory, and the computation algorithms needed to analyze single and combination drug data. Numerous examples accompany a presentation that illustrates the calculations and experimental design considerations for modern drug analysis.




RNA Infrastructure and Networks


Book Description

RNAs form complexes with proteins and other RNAs. The RNA‐infrastructure represents the spatiotemporal interaction of these proteins and RNAs in a cell‐wide network. RNA Infrastructure and Networks brings together these ideas to illustrate the scope of RNA‐based biology, and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways. This book is but a taste of the wide range of RNA‐based mechanisms that connect in the RNA infrastructure.




Synergistic Selection: How Cooperation Has Shaped Evolution And The Rise Of Humankind


Book Description

'Nothing about the evolution of biological complexity makes sense except in the light of synergy.' Peter Corning's new book is being hailed as a major contribution to what is perhaps the greatest shift in our understanding of evolution since The Origin of Species. It's a tour de force that takes us on a synergy-guided tour of the history of life. As Corning puts it, 'life on Earth has been a synergistic phenomenon from the get go.' Corning also shows how synergy has been a key to human evolution, including the rise of complex modern societies. 'Cooperation may have been the vehicle, but synergy was the driver.' As we now face a tipping point and another major transition in evolution, Corning offers us a synergy-based road-map to the future. 'One of the great take-home lessons from the epic of evolution is that cooperation produces synergy, and synergy is the way forward. The arc of evolution bends toward synergy.'Related Link(s)