Advanced Brain Neuroimaging Topics in Health and Disease


Book Description

The brain is the most complex computational device we know, consisting of highly interacting and redundant networks of areas, supporting specific brain functions. The rules by which these areas organize themselves to perform specific computations have only now started to be uncovered. Advances in non-invasive neuroimaging technologies have revolutionized our understanding of the functional anatomy of cortical circuits in health and disease states, which is the focus of this book. The first section of this book focuses on methodological issues, such as combining functional MRI technology with other brain imaging modalities. The second section examines the application of brain neuroimaging to understand cognitive, visual, auditory, motor and decision-making networks, as well as neurological diseases. The use of non-invasive neuroimaging technologies will continue to stimulate an exponential growth in understanding basic brain processes, largely as a result of sustained advances in neuroimaging methods and applications.




Imaging of the Human Brain in Health and Disease


Book Description

Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. - A focused introduction to imaging healthy and diseased brains - Focuses on the primary neurotransmitter release - Includes sigma, acetylcholine, opioid, and dopamine receptors - Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease







Advanced MR Neuroimaging


Book Description

Over the last decade, some of the greatest achievements in the field of neuroimaging have been related to remarkable advances in magnetic resonance techniques, including diffusion, perfusion, magnetic resonance spectroscopy, and functional MRI. Such techniques have provided valuable insights into tissue microstructure, microvasculature, metabolism and brain connectivity. Previously available mostly in research environments, these techniques are now becoming part of everyday clinical practice in a plethora of clinical MR systems. Nevertheless, despite growing interest and wider acceptance, there remains a lack of a comprehensive body of knowledge on the subject, exploring the intrinsic complexity and physical difficulty of the techniques. This book focuses on the basic principles and theories of diffusion, perfusion, magnetic resonance spectroscopy, and functional MRI. It also explores their clinical applications and places emphasis on the associated artifacts and pitfalls with a comprehensive and didactic approach. This book aims to bridge the gap between research applications and clinical practice. It will serve as an educational manual for neuroimaging researchers and radiologists, neurologists, neurosurgeons, and physicists with an interest in advanced MR techniques. It will also be a useful reference text for experienced clinical scientists who wish to optimize their multi-parametric imaging approach.




Diseases of the Brain, Head and Neck, Spine 2020–2023


Book Description

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.




Neuropsychology


Book Description

Compiled reviews of the recent literature are a long established tradition in the laboratory and clinical sciences, and bring to their professions a useful and timely summary of the advances that have been made in the field. Neuropsychology has matured as a science and profession to support a like effort to summarize, across domains, the direction and momentum in the field. The authors are authorities in the subjects they review and provide for the investigator, practitioner and student an overview of the important developments in neuropsychology that cannot be realized from perusal of the journals alone. Interest in the reviews are likely to go beyond the discipline of neuropsychology, and will extend to all with an interest in science of brain-behavior relationships, in the study of disease and injury as they affect brain function, and in the rehabilitation of the individual who has suffered insult to brain. Chapters cover the pragmatic application of tests and test findings to improve our understanding of the behavior of individuals who present with neurocognitive disorders. Where there is interest in efficiently acquiring a sound perspective of the important advances and the future direction of neuropsychology, Neuropsychology: A Review of Science and Practice will provide the means for so doing as no other publication can offer.




Physical Aspects of Organs and Imaging


Book Description

Medical Physics covers the applied branch of physics concerned with the application of concepts and methods of physics to diagnostics and therapeutics of human diseases. The first part, Physical and Physiological Aspects of the Body, covers those body systems that have a strong physical component, such as body mechanics, energy household, action potential, signal transmission in neurons, respiratory and circulatory system as well as visual and sound perception. The second part of this volume, Imaging Modalities without Ionizing Radiation, introduces sonography, endoscopy, and magnetic resonance imaging. The second volume complements the imaging modalities with the use of ionizing radiation: x-ray radiography, scintigraphy, SPECT, and PET. This first part is followed by chapters on radiation treatment of tumors, in particular x-ray radiotherapy, proton and neutron radiation therapy, and brachytherapy. The last part treats aspects of diagnostics and therapeutics beyond radiology, including laser applications, multifunctional nanoparticles and prosthetics. This first volume - connects the basic principles of physics with the functionality of the body and with physical methods used for diagnostics and therapeutics. - covers the first part of the entire field, including the physics of the body and imaging methods without the use of ionizing radiation. - provides an introduction for Bachelor students to the main concepts of Medical Physics during their first semesters guiding them to further specialized and advanced literature. - contains many questions & answers related to the content of each chapter. - is also available as a set together with Volume 2. Contents Part A: Physical and physiological aspects of the body Brief overview of body parts and functions Body mechanics and muscles Elastomechanics: bones and fractures Energy household of the body Resting potential and action potential Signal transmission in neurons Electrophysical aspects of the heart The circulatory system The respiratory system Kidneys Basic mechanism of vision Sound and sound perception Part B: Imaging modalities without ionizing radiation Sonography Endoscopy Magnetic resonance imaging Questions & answers




Physical Aspects of Diagnostics


Book Description

The updated edition of the second of three volumes on Medical Physics presents modern physical methods for medical diagnostics. It provides a solid background on imaging techniques that use non-ionizing probes (ultrasound, endoscopy including CLE and OCT, MRI) and imaging techniques that use ionizing radiation (X-ray radiography, CT, SPECT, PET). Radiation sources, interactions of radiation with matter and radiation protection for x-rays, -rays, protons and neutrons are presented. Some of these topics are also relevant to the therapeutic applications presented in Volume 3. NEW: highlighted boxes emphasize specifi c topics; math boxes explain more advanced mathematical issues; each chapter concludes with a summary of the key concepts, questions, a self-assessment of the acquired competence and exercises. The appendix provides answers to questions and solutions to exercises.




The Neuroscience of Normal and Pathological Development


Book Description

Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. It also examines pharmacological and non-pharmacological interventions of development-related conditions. Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet is a comprehensive reference on the genetic and behavioral features associated with proper and abnormal development. This book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the physiological, behavioral, molecular, and cellular features of neurodevelopment. It also examines in vitro and in vivo modelling of development with stem cells and model systems.Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience Of Development: - Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of development - Features sections on diagnosis and biomarkers - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Focuses on neurodevelopmental disorders and environmental factors that influence neural development - Includes more than 500 illustrations and tables Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and Diet: - Provides the most comprehensive coverage of the broad range of topics related to the neuroscience of development - Features sections on the genetics of developmental conditions and accompanying behavior - Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding - Focuses on neurodevelopmental disorders and environmental factors that influence neural development - Includes more than 500 illustrations and tables




The Oxford Handbook of Functional Brain Imaging in Neuropsychology and Cognitive Neurosciences


Book Description

The Oxford Handbook of Functional Brain Imaging in Neuropsychology and Cognitive Neurosciences describes in a readily accessible manner the several functional neuroimaging methods and critically appraises their applications that today account for a large part of the contemporary cognitive neuroscience and neuropsychology literature. The complexity and the novelty of these methods often cloud appreciation of the methods' contributions and future promise. The Handbook begins with an overview of the basic concepts of functional brain imaging common to all methods, and proceeds with a description of each of them, namely magnetoencephalography (MEG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), diffusion tensor imaging (DTI), and transcranial magnetic stimulation (TMS). Its second part covers the various research applications of functional neuroimaging on issues like the function of the default mode network; the possibility and the utility of imaging of consciousness; the search for mnemonic traces of concepts; human will and decision-making; motor cognition; language; the mechanisms of affective states and pain; the presurgical mapping of the brain; and others. As such, the volume reviews the methods and their contributions to current research and comments on the degree to which they have enhanced our understanding of the relation between neurophysiological activity and sensory, motor, and cognitive functions. Moreover, it carefully considers realistic contributions of functional neuroimaging to future endeavors in cognitive neuroscience, medicine, and neuropsychology.




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