Advances in Antiparasitic Therapies and Drug Delivery


Book Description

Higee Chemical Reaction Engineering systematically discusses the fundamentals, principles and methods of molecular mixing and reaction process intensification. The book demonstrates in detail the implementation approach, process and effectiveness of Higee chemical reaction engineering through novel industrial case studies that help industrial technicians to select reaction intensification technology route more scientifically. The book covers the innovation and development process of Higee chemical reaction engineering, hydrodynamics behavior in Higee reactors, equipment design principles and methods, multiphase reaction of liquid-liquid, gas-liquid, gas-solid, gas-liquid-solid and reactive crystallization process intensification principles and effectiveness. It also prospects the future development direction and hot application fields of Higee chemical reaction process intensification. Higee Chemical Reaction Engineering is a systematic summary of several national award and key projects, such as the State Technological Innovation Award, State Science and Technology Advancement Award, National Natural Science Foundation of China, National key R&D Program of China, National ''863'' Program of China, National ''973'' Program of China and also some international cooperation. - Handles high gravity process intensification technology - Covers theoretical innovation in multiphase reaction intensified by high gravity - Presents engineering application cases in chemical engineering, materials science, ocean engineering, and environmental engineering - Provides systematic understanding of high gravity process intensification through theories and industrial applications




Drug Delivery Systems: Advanced Technologies Potentially Applicable in Personalised Treatment


Book Description

This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM). It focuses on the theme of “Drug delivery systems: advanced technologies potentially applicable in personalised treatments”. The critical topics involving the development and preparation of effective drug delivery systems, such as: polymers available, self-assembly, nanotechnology, pharmaceutical formulations, three dimensional structures, molecular modeling, tailor-made solutions and technological tendencies, are carefully discussed. The understanding of these areas constitutes a paramount route to establish personalised and effective solutions for specific diseases and individuals.




Nanoengineered Biomaterials for Advanced Drug Delivery


Book Description

Nanoengineered Biomaterials for Advanced Drug Delivery explores the latest advances in the applications of nanoengineered biomaterials in drug delivery systems. The book covers a wide range of biomaterials and nanotechnology techniques that have been used for the delivery of different biological molecules and drugs in the human body. It is an important resource for biomaterials scientists and engineers working in biomedicine and those wanting to learn more on how nanoengineered biomaterials are being used to enhance drug delivery for a variety of diseases. Nanoengineered biomaterials have enhanced properties that make them more effective than conventional biomaterials as both drug delivery agents, and in the creation of new drug delivery systems. As nanoengineering becomes more cost-effective, nanoengineered biomaterials have become more widely used within biomedicine. - Offers an informed overview on how nanoengineering biomaterials enhance their properties for drug delivery applications - Discusses the major applications of nanoengineered biomaterials for drug delivery - Outlines the major challenges for successfully implementing nanoengineered biomaterials into existing drug delivery systems




Nanopharmaceutical Advanced Delivery Systems


Book Description

The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.




Small Animal Clinical Pharmacology


Book Description

Small Animal Clinical Pharmacology is a practical, clinically-oriented pharmacology text designed to provide the veterinary student and practitioner with all the relevant information needed when designing drug treatment regimens for pets in small animal veterinary practice. Comprehensively updated and revised, the second edition of this core text covers essential new information on drugs used in the management of a range of presenting conditions including heart disease and cardiac arrhythmias. For the second edition new authors, superb new illustrations and a second colour have all been introduced. With its unique approach combining a thorough understanding of the pharmacological action of drugs with a basic understanding of the relevant physiology and pathophysiology of systems and tissues affected, Small Animal Clinical Pharmacology continues to be an indispensable book for all veterinary students and practitioners. Organised by drug class in a uniform and detailed structure which means it is easy to locate key information on dose rates, routes of administration, drug interactions and special considerations at a glance Key chapters based around treatment of disorders of particular body systems, eg cardiovascular and thyroid disorders Essential introductory chapters covering pharmacokinetics, general pharmacological principles and adverse reactions for a thorough basic grounding in the subject All authors are experienced clinicians and recognised experts in their field who bring a down to earth and practical approach to the text




The Discovery of New Medicines in Academia


Book Description

The Discovery of New Medicines in Academia, Volume 100 highlight examples of discoveries originating in academia that have been successfully translated into promising therapeutics that have advanced into clinical trials. Chapters in this release cover Design and Discovery of Itaconate prodrugs for Alopecia Areata, Hydroxyl-Dendrimer Delivery System for Neurological Disease, Development of allosteric modulators of G protein-coupled receptors for Psychiatric Disease, Targeting the constitutively active ERK1/2 signaling kinase for cancer, mRNA reprogramming of myeloid cells for tumor immunotherapy, Development of novel drugs targeting protein-protein interactions, and much more.Additional sections cover Neuro-steroids and analogs for the treatment of epilepsy, Development of inhibitors of eukaryotic translation, Discovery/development of antiviral, anticancer and/or anti-inflammatory agents, Discovery of novel anti-infective agents, Targeting proliferating cell nuclear antigen (PCNA) for cancer, and Implementation and Evolution of Quantitative Systems Pharmacology to Patient Digital Twins and Biomimetic Twins. - Provides recent examples of successful academic drug discovery projects in multiple disease areas, including oncology, immunology, neurology, and infectious diseases - Presents diverse examples, including small molecule, biologic, and nanomedicine-based therapeutics - Discusses innovative artificial intelligence platforms utilized in academic drug discovery efforts




Guidelines for the Treatment of Malaria


Book Description

"The purpose of this document is to provide comprehensible, global, evidence-based guidelines to help formulate policies and protocols for the treatment of malaria. Information is presented on the treatment of uncomplicated malaria, including disease in special groups (young children, pregnant women, people who are HIV positive, travellers from non-malaria endemic regions) and in complex emergency situations and severe malaria."--Publisher's description.




Encapsulation of Active Molecules and Their Delivery System


Book Description

Encapsulation of Active Molecules and Their Delivery System covers the key methods of preparation of encapsulation, as well as release mechanisms and their applications in food, biotechnology, metal protection, drug delivery, and micronutrients delivery in agriculture. The book also provides real-life examples of applications in food and other industries. Sections encompasses (i) Synthesis and characterization methods of micro- and nanocarriers as the delivery systems, (ii) Up-to-date encapsulation techniques in the areas of pharmaceuticals, nutraceuticals and corrosion, (iii) The release methods of the encapsulated materials, and (iv) Industry perspectives, including scale up of the processes. - Focuses on encapsulation processes in chemical and materials engineering and biotechnology - Provides a relevant resource for the pharmaceutical and food industries - Presents wide coverage on the entrapment of molecules that scales-up to industrial sized needs




Advanced Nanomaterials for Point of Care Diagnosis and Therapy


Book Description

Advanced Nanomaterials for Point of Care Diagnosis and Therapy provides an overview of technological and emerging novel trends in how point-of-care diagnostic devices are designed, miniaturized built, and delivered at different healthcare set ups. It describes the significant technological advances in fundamental diagnostic components and recent advances in fully integrated devices designed for specific clinical use. The book covers state-of-the-art fabrication of advances materials with broad spectrum therapeutic applications. It includes drug delivery, biosensing, bioimaging and targeting, and outlines the development of inexpensive, effective and portable in vitro diagnostics tools for any purpose that can be used onsite. Sections also discuss drug delivery, biosensing, bioimaging and targeting and various metal, metal oxide and non-metal-based nanomaterials that are developed, surface modified, and are being explored for diagnosis, targeting, drug delivery, drug release and imaging. The book concludes with current needs and future challenges in the field. Outlines the needs and challenges of point-of-care diagnostics Describes the fundamentals of application of nanomaterials as interesting building blocks for biosensing Overviews the different detection methods offered by using nanomaterials Explains the advantages and drawbacks of nanomaterial-based sensing strategies Describes the opportunities offered by technology as a cost-efficient biosensing platform




Saving Lives, Buying Time


Book Description

For more than 50 years, low-cost antimalarial drugs silently saved millions of lives and cured billions of debilitating infections. Today, however, these drugs no longer work against the deadliest form of malaria that exists throughout the world. Malaria deaths in sub-Saharan Africaâ€"currently just over one million per yearâ€"are rising because of increased resistance to the old, inexpensive drugs. Although effective new drugs called "artemisinins" are available, they are unaffordable for the majority of the affected population, even at a cost of one dollar per course. Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance examines the history of malaria treatments, provides an overview of the current drug crisis, and offers recommendations on maximizing access to and effectiveness of antimalarial drugs. The book finds that most people in endemic countries will not have access to currently effective combination treatments, which should include an artemisinin, without financing from the global community. Without funding for effective treatment, malaria mortality could double over the next 10 to 20 years and transmission will intensify.




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