Advances in Integrative Medicine for Neurodegenerative Diseases: From Basic Research to Clinical Practice


Book Description

Neurodegenerative diseases (NDs) are disorders characterized by progressive loss of neurons and may finally lead to severe impairments even death. NDs are age-dependent disorders, growing evidence suggests that nearly all aged brains exhibit characteristic changes that are associated with neurodegeneration. As the global rapidly aging population, the prevalence of NDs is which have become the most dreaded disease of aged people. Studies report that the expenses of these older patients with NDs exceed the total medical expenses of patients with cancer and cardiovascular diseases.




Integrative Neurology


Book Description

"Neurology is a quantitively small corner of medicine that, increasingly, occupies a position of outsized importance and distinction in both the practice of medicine and in the health and well-being of society. The Decade of the Brain came into public awareness in 1990 as an initiative of president George W. Bush involving the NIH and NIMH "to enhance public awareness of the benefits to be derived from brain research"(1). In the intervening 20 years since 1999, we have seen significant increases in understanding the myriad of neurological diseases that confront society"--




The Benefits of Natural Products for Neurodegenerative Diseases


Book Description

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.




Integrative approach to Parkinson’s disease


Book Description

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.




Neurodegenerative Diseases—Advances in Research and Treatment: 2013 Edition


Book Description

Neurodegenerative Diseases—Advances in Research and Treatment: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Tauopathies. The editors have built Neurodegenerative Diseases—Advances in Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Tauopathies in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Neurodegenerative Diseases—Advances in Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.




Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future


Book Description

This book will compile a collection of chapters dedicated to varied aspects of PPPM in neuropsychiatric and neurodegenerative diseases. Among the topics to be covered are: Recent advances in ALS research News about Clinical aspects and advanced therapy approaches in personalized treatment of ALS Schizophrenia: New treatments and clinical aspects Predictive, Preventive and Personalised Medicine in aging macular degeneration Advances in Multiple Sclerosis Pharmacogenetics, Tailoring Treatment Efficacy, Safety and Regimen Selection Multiple sclerosis related biomarkers: perspectives for clinical application Preventive clinical trials in brain aging: new trends & the need of guidelines MCI_ clinical guidelines in early diagnosis of dementia Alzheimer's disease: diagnostics, prognostics and the road to prevention Biomarkers for early diagnosis of Parkinson's and Alzheimer's diseases Synucleinopathies, tauopathies, TDP-43 proteinopathies and amyloidosis PSP, MSA and other parkinsonisms




Basic Science Methods for Clinical Researchers


Book Description

Basic Science Methods for Clinical Researchers addresses the specific challenges faced by clinicians without a conventional science background. The aim of the book is to introduce the reader to core experimental methods commonly used to answer questions in basic science research and to outline their relative strengths and limitations in generating conclusive data. This book will be a vital companion for clinicians undertaking laboratory-based science. It will support clinicians in the pursuit of their academic interests and in making an original contribution to their chosen field. In doing so, it will facilitate the development of tomorrow's clinician scientists and future leaders in discovery science. - Serves as a helpful guide for clinical researchers who lack a conventional science background - Organized around research themes pertaining to key biological molecules, from genes, to proteins, cells, and model organisms - Features protocols, techniques for troubleshooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data - Appendices provide resources for practical research methodology, including legal frameworks for using stem cells and animals in the laboratory, ethical considerations, and good laboratory practice (GLP)




Handbook of Innovations in Central Nervous System Regenerative Medicine


Book Description

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. - Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance - Discusses the limitations of present therapies used in the clinics - Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies - Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path




HEALTH & SCIENCE 2024: Basic Medical Sciences -CENTRAL NERVOUS SYSTEM-


Book Description

CONTENTS ACTION POTENTIAL IN THE CENTRAL NERVOUS SYSTEM - Enes AKYUZ GENETIC ASPECTS IN NEURODEGENERATIVE DISEASES: UNDERSTANDING THE MOLECULAR LANDSCAPE - Hani H. S. ALSAADONI USING THE HUMAN GENE MUTATION DATABASE IN NEURODEGENERATIVE DISEASE - Duygu SARI AK NEUROLOGICAL DISEASE AND AXONAL TRANSPORT - Gamze YEŞİLAY NEUROTRANSMITTERS IN NEURODEGENERATIVE DISORDERS AND THE CENTRAL NERVOUS SYSTEM - Merve BEKER, Mustafa Caglar BEKER IMMUNE REGULATION IN NEUROIMMUNOLOGY - Sevgi KALKANLI TAS, Duygu KIRKIK GUT-BRAIN AXIS: THE EFFECT OF GUT MICROBIOTA ON CENTRAL NERVOUS SYSTEM FUNCTION - Ayşe Selma ÇİZMECİ THE ROLE OF MICROBIOTA IMBALANCE IN CENTRAL NERVOUS SYSTEM DISORDERS - Halil KURT, Kübra CAN KURT DEVELOPMENT AND HISTOLOGY OF BRAIN STEM NUCLEI - Kübra ŞEVGİN HISTOLOGY AND EMBRYOLOGY OF CEREBELLAR NUCLEI - Zeliha YETİM DEVELOPMENT OF SPINAL CORD AND MALFORMATIONS - Salime Pelin ERGUVEN NEUROANATOMY OF THE CORPUS STRIATUM - Burak KARIP AMYGDALA’S NEUROANATOMICAL CHARACTERISTICS IN RELATION TO NEURODEGENERATIVE DISEASE - Papatya KELEŞ, Cansu KİBAR NEUROANATOMY OF THE SUBSTANTIA NIGRA - Mete BÜYÜKERTAN, Özge COŞKUN NEUROANATOMY, LIMBIC SYSTEM - Umut Serkan SÖZTANACI, Doruk IŞIK FORMATIO RETICULARIS AND NEUROANATOMY - Nurullah YÜCEL, Tayfun AYGÜN NEUROANATOMY OF THE TEMPORAL LOBE - Fatma OK ENDOCRINE FUNCTIONS OF THE CENTRAL NERVOUS SYSTE - Pınar ÇAKAN HIPPOCAMPAL NEOCORTICAL INTERACTIONS IN MEMORY FORMATION - Seymanur YILMAZ TASCI TREATMENT STRATEGIES BASED ON MICRORNAS IN NEURODEGENERATIVE DISEASES - Merve KABASAKAL ILTER LARGE BRAIN NETWORKS: OVERVIEW AND NEW FINDINGS - Aynur FEYZIOGLU, Ozan AKBAS INTERACTIONS BETWEEN RENAL METABOLIC DISORDERS AND THE CENTRAL NERVOUS SYSTEM - Serap YADİGAR, Banu ŞAHİN YILDIZ CENTRAL NERVOUS SYSTEM AND CARDIAC ELECTRICAL REMODELLING IN NEURODEGENERATIVE DISORDERS - Mustafa YILDIZ, Idil BUGDAY MICROGLIA AND ASTROCYTES' INVOLVEMENT IN NEUROINFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES - Gulam HEKIMOGLU




Anti-aging Drugs


Book Description

Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.