› › Alopecia Areata Navigating The Complexities Of Genetics Immunology And Personalized Care

Alopecia Areata: Navigating the Complexities of Genetics, Immunology, and Personalized Care

Author : Dr. Spineanu Eugenia

Publisher : Dr. Spineanu Eugenia

Page : 132 pages

File Size : 26,88 MB

Release : 2024-09-30

Category : Medical

ISBN :

Get eBook

Book Description

"Unveiling Alopecia Areata: Navigating the Complexities of Genetics, Immunology, and Personalized Care" is a groundbreaking treatise that delves into the multifaceted realm of alopecia areata, an autoimmune-induced hair loss condition. This comprehensive exploration spans from the foundational definitions and classifications to the cutting-edge frontiers of personalized medicine. The treatise meticulously unravels the historical evolution of knowledge surrounding alopecia areata, tracing its journey from early observations to contemporary research breakthroughs. One of the focal points of the treatise is the intricate interplay between genetics and immunology in the development and progression of alopecia areata. It meticulously examines the genetic factors contributing to susceptibility and hereditary patterns, shedding light on the evolving landscape of genetic research in this field. Furthermore, the exploration extends into the complex immunological cascades involved in the autoimmune attack on hair follicles, emphasizing the role of T cells, cytokines, and immune system dysregulation. A significant highlight of the treatise lies in its in-depth analysis of personalized medicine approaches for alopecia areata. Recognizing the diverse manifestations and treatment responses across individuals, the treatise explores how genetic and immunological insights guide tailored interventions. From predictive biomarkers and treatment optimization to individualized therapeutic combinations, the treatise outlines the exciting possibilities and challenges of navigating a personalized care paradigm.



Cancer Genetics and Psychotherapy

Author : Parvin Mehdipour

Publisher : Springer

Page : 1189 pages

File Size : 14,90 MB

Release : 2017-09-20

Category : Medical

ISBN : 3319645501

Get eBook

Book Description

The aim of this book is to provide the readers with the most comprehensive and latest accounts of research and development in this field by emphasizing on the manner of relation between doctors and cancer patients in direction of improving the patients’ style of life. This book, partly, will deal with psychotherapy by considering cancer patients, benefits, hazards and also social impacts including life style. The social supports as the key and influential paradigms will be challenged as a comparative insight by considering the global unity in order to provide a reasonable model to improve the interaction between cancer and psychological nest. In this book, the real stories of cancer patient will be also provided. The initial insight of sections includes: 1) Brief classifications and key points of clinical and histopatological aspects of each organ. 2) Brief view of genetic alterations in each organ. 3) Therapeutic aspects. 4) Brief classifications and key points of Psychology in cancer. 5) The interactions of clinical aspects with psychological field.



The Difficult Hair Loss Patient

Author : Ralph M. Trüeb

Publisher : Springer

Page : 338 pages

File Size : 46,28 MB

Release : 2015-09-02

Category : Medical

ISBN : 3319197010

Get eBook

Book Description

You could read every textbook available on hair growth and disorders, and still not be able to treat hair loss effectively. In every art, there are many techniques, but few principles. The only way to achieve success is to have a firm foundation of principles to build upon, and the right attitude about how to achieve your goals. This book offers a detailed guide that goes beyond the technical aspects of trichology and evidence based medicine, providing specialists and primary care physicians experienced in the basic management of hair loss with the additional know-how they need to master the ultimate challenge of difficult hair loss patients. First, the prerequisites for successful management of hair loss are reviewed – basically, making a diagnosis and understanding the patient and his or her problem. Then, guidelines on the management of difficult dermatologic conditions and of psychopathological disorders associated with hair loss are provided. Lastly, important aspects of follow-up are covered–specifically the problems of adverse effects, patient non-compliance, and their management–before concluding with exemplary case studies of successful treatment of alopecia and related conditions.



Mapping and Sequencing the Human Genome

Author : National Research Council

Publisher : National Academies Press

Page : 128 pages

File Size : 25,59 MB

Release : 1988-01-01

Category : Science

ISBN : 0309038405

Get eBook

Book Description

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.



Braun-Falco ́s Dermatology

Author : Walter H.C. Burgdorf

Publisher : Springer

Page : 0 pages

File Size : 10,98 MB

Release : 2009

Category : Medical

ISBN : 9783540293163

Get eBook

Book Description

Also the 3rd edition of "Dermatology" covers all the classical and related fields of dermatology, providing a wealth of information on diagnostic methods, clinical features, pathophysiology, and differential diagnosis. About 950 excellent photos and diagrams help the reader become acquainted with the immense variety of dermatological diseases. The contents of all chapters have been updated. New chapters have been included covering numerous subjects, e.g. dermatopathology, sonography, disorders of chromosomal instability and defective DNA repair, aging skin, sport dermatology, aesthetic therapy. The book is a must for every doctor confronted with dermatological problems.



The Mosaic of Autoimmunity

Author : Yehuda Shoenfeld

Publisher : Elsevier Science Limited

Page : 523 pages

File Size : 37,27 MB

Release : 1989

Category : Medical

ISBN : 9780444811844

Get eBook

Book Description

This book comprehensively sets out the common aetiopathogenetic mechanisms shared by many, apparently diverse, diseases of the immune system. Unlike most other texts it does not emphasise the differences between autoimmune diseases, but establishes their many common links including hormonal effects, dietary and immunogenetic influences, complement deficiencies and environmental factors. Special attention is given to the effects of ageing and the relationship with malignancies. The scope of the book is very broad so as to cover the integration of the many diverse components which interact to cause autoimmunity, and it contains many 1988 and 1989 references and over 100 figures and tables, offering an attractive, up-to-date guide to modern concepts. It will greatly assist immunologists wishing to enter the field of autoimmunity, and will serve as an invaluable reference work for those already working in it.



Immunopharmacogenomics

Author : Yusuke Nakamura

Publisher : Springer

Page : 162 pages

File Size : 49,1 MB

Release : 2015-09-18

Category : Medical

ISBN : 4431557261

Get eBook

Book Description

This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge.



Never Be Sick Again

Author : Raymond Francis

Publisher : Simon and Schuster

Page : 476 pages

File Size : 12,16 MB

Release : 2010-01-01

Category : Health & Fitness

ISBN : 0757396283

Get eBook

Book Description

One day Raymond Francis, a chemist and a graduate of MIT, found himself in a hospital, battling for his life. The diagnosis: acute chemical hepatitis, chronic fatigue, multiple chemical sensitivities, and several autoimmune syndromes, causing him to suffer fatigue, dizziness, impaired memory, heart palpitations, diarrhea, numbness, seizures and numerous other ailments. Knowing death was imminent unless he took action, Francis decided to research solutions for his disease himself. His findings and eventual recovery led him to conclude that almost all disease can be both prevented and reversed. In Never Be Sick Again, Francis presents a seminal work based on these findings — a revolutionary theory of health and disease: there is only one disease (malfunctioning cells), only two causes of disease (deficiency and toxicity), and six pathways to health and disease (nutrition, toxins, psychological, physical, genetic, and medical). This remarkable book answers the questions: What is health? What is disease? Why do people get sick? How can disease be prevented? How can it be reversed? It will teach readers, in one easy lesson, an entirely new way to look at health and disease — an approach that is easy to understand, yet so powerful that they may, indeed, never have to be sick again. Providing a basic understanding of health and disease, this book takes the mystery out of disease. It provides readers, no matter what their present physical condition, a holistic approach to living that will empower them to get well — and stay well.



Jubb, Kennedy & Palmer's Pathology of Domestic Animals: Volume 1

Author : Grant Maxie

Publisher : Elsevier Health Sciences

Page : 1250 pages

File Size : 25,49 MB

Release : 2015-08-16

Category : Medical

ISBN : 070206842X

Get eBook

Book Description

With an emphasis on the disease conditions of dogs, cats, horses, swine, cattle and small ruminants, Jubb, Kennedy, and Palmer's Pathology of Domestic Animals, 6th Edition continues its long tradition of being the most comprehensive reference book on common domestic mammal pathology. Using a body systems approach, veterinary pathology experts provide overviews of general system characteristics, reactions to insult, and disease conditions that are broken down by type of infectious or toxic insult affecting the anatomical subdivisions of each body system. The sixth edition now boasts a new full-color design, including more than 2,000 high-resolution images of normal and abnormal organs, tissues, and cells. Updated content also includes evolved coverage of disease agents such as the Schmallenberg virus, porcine epidemic diarrhea virus, and the porcine deltacoronavirus; plus new information on molecular-based testing, including polymerase chain reaction (PCR) and in-situ hybridization, keep you abreast of the latest diagnostic capabilities. - Updated content includes new and evolving pathogens and diagnostic techniques. - Updated bibliographies give readers new entry points into the rapidly expanding literature on each subject. - NEW! High-resolution color images clearly depict the diagnostic features of hundreds of conditions. - NEW! Introduction to the Diagnostic Process chapter illustrates the whole animal perspective and details the approaches to systemic, multi-system, and polymicrobial disease. - NEW! Coverage of camelids is now included in the reference's widened scope of species. - NEW! Team of 30+ expert contributors offers the latest perspective on the continuum of issues in veterinary pathology. - NEW! Expanded resources on the companion website include a variety of helpful tools such as full reference lists with entries linked to abstracts in Pub Med and bonus web-only figures. - NEW! Full-color design improves the accessibility of the text.



Personalized Medicine in Oncology

Author : Ari VanderWalde

Publisher :

Page : 174 pages

File Size : 33,14 MB

Release : 2022

Category :

ISBN : 9783036528205

Get eBook

Book Description

Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests.The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first “site-agnostic” drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic “signatures” that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.



Recent Books