Lighthousekeeping


Book Description

An orphaned girl is held spellbound by the tales of a lighthouse keeper on the Scottish coast, in a novel by the Costa Award-winning author of The Passion. After her mother is literally swept away by the savage winds off the Atlantic coast of Salts, Scotland, never to be seen again, the orphaned Silver is feeling particularly unmoored. Taken in by the mysterious keeper of a lighthouse on Cape Wrath, Silver finds an anchor in Mr. Pew—blind, as old and legendary as a unicorn, and a yarn spinner of persuasive power. The tale he has to tell Silver is that of a nineteenth-century clergyman named Babel Dark, whose life was divided between a loving light and a mask of deceit. Peopled with such luminaries as Charles Darwin and Robert Louis Stevenson, Mr. Pew’s story within a story within a story soon unfolds like a map. It’s one that Silver must follow if she’s to be led through her own darkness, and to find her own meaning in life, in this novel by a winner of the Costa, Lambda, and E.M. Forster Awards, the author of Oranges are Not the Only Fruit; Why Be Happy When You Could Be Normal? and other acclaimed works. “In her sea-soaked and hypnotic eighth novel, Winterson turns the tale of an orphaned young girl and a blind old man into a fable about love and the power of storytelling…Atmospheric and elusive, Winterson's high-modernist excursion is an inspired meditation on myth and language.”—The New Yorker




Limbic-predominant Age-related TDP-43 Encephalopathy


Book Description

Book 9 focuses on a new dementia type, LATE, mistaken as Alzheimer's disease until now.LATE stands for Limbic-predominant age-related TDP-43 encephalopathy, the protein buildup responsible for this dementia. This book is organic, like the series, meaning we never consider our books as finished. Science evolves, which is why our books go through continuous updates. Since LATE is a new dementia classification, we expect continuous further information to emerge. Watch Amazon alerts for potential digital updates. We provide free digital copies on all paperback purchases, so everybody receives free updates.




The Secret Keeper


Book Description

A cloth bag containing ten copies of the title.




Daddy Love


Book Description

From the author of Bellefleur: A “psychologically incisive” glimpse into the mind of a deranged predator and the boy he abducts to be his son (Booklist). Robbie Whitcomb is five years old when he’s taken from his mother in a mall parking lot. In her attempt to chase the kidnapper, she’s left badly injured and permanently disfigured. Such are the methods of the man who calls himself Daddy Love—a man known to the rest of the world as charismatic preacher Chester Cash. For the next six years, Robbie is to be Daddy’s son. That means doing whatever Daddy says—and giving him whatever he wants. Soon Robbie learns to accept his new name, Gideon. He also learns that he is not the first of Daddy Love’s sons. And that each of the others, after reaching a certain age, was never seen again. As Robbie’s mother recovers from her wounds, her life and marriage are a daily struggle. But as years go by, she maintains a flicker of hope that her son is still alive. Meanwhile, Robbie approaches the “bittersweet age” with no illusions about his fate. But somewhere within this tortured child lies a spark of rebellion. And he knows all too well what survival requires. “After all these years, Joyce Carol Oates can still give me the creeps.” —Marilyn Stasio, The New York Times Book Review “A lean and disturbing tale that reverberates after its ending.” —The Columbus Dispatch “Oates makes us squirm as she forces us to see some of the action through Love’s twisted and warped perspective.” —Kirkus Reviews “This unsettling tale showcases Oates’s masterful storytelling.” —Publishers Weekly




Neuroacanthocytosis Syndromes


Book Description

Neuroacanthocytosis Syndromes is the first comprehensive review of a field that has not yet received the attention it deserves. Affecting the brain as well as the circulating red cells, these multi-system disorders in the past had often been mistaken for Huntington's disease. Recent breakthroughs have now identified the molecular basis of several of these. This volume grew out of the first international scientific meeting ever devoted to neuroacanthocytosis and provides in-depth information about the state of the art. Its thirty chapters were written by the leading authorities in the field to cover the clinical as well as the basic science perspective, including not only molecular genetics but also experimental pharmacology and cell membrane biology, among others. The book vehemently poses the question of how the membrane deformation of circulating red blood cells relates to degeneration of nerve cells in the brain, the basal ganglia, in particular. It provides a wealth of data that will help to solve an intriguing puzzle and ease the suffering of those affected by one of the neuroacanthocytosis syndromes.




EBOOK: A Sociology of Mental Health and Illness


Book Description

How do we understand mental health problems in their social context? A former BMA Medical Book of the Year award winner, this book provides a sociological analysis of major areas of mental health and illness. The book considers contemporary and historical aspects of sociology, social psychiatry, policy and therapeutic law to help students develop an in-depth and critical approach to this complex subject.New developments for the fifth edition include: Brand new chapter on prisons, criminal justice and mental health Expanded coverage of stigma, class and social networks Updated material on the Mental Capacity Act, Mental Health Act and the Deprivation of Liberty A classic in its field, this well established textbook offers a rich and well-crafted overview of mental health and illness unrivalled by competitors and is essential reading for students and professionals studying a range of medical sociology and health-related courses. It is also highly suitable for trainee mental health workers in the fields of social work, nursing, clinical psychology and psychiatry. "Rogers and Pilgrim go from strength to strength! This fifth edition of their classic text is not only a sociology but also a psychology, a philosophy, a history and a polity. It combines rigorous scholarship with radical argument to produce incisive perspectives on the major contemporary questions concerning mental health and illness. The authors admirably balance judicious presentation of the range of available understandings with clear articulation of their own positions on key issues. This book is essential reading for everyone involved in mental health work." Christopher Dowrick, Professor of Primary Medical Care, University of Liverpool, UK "Pilgrim and Rogers have for the last twenty years given us the key text in the sociology of mental health and illness. Each edition has captured the multi-layered and ever changing landscape of theory and practice around psychiatry and mental health, providing an essential tool for teachers and researchers, and much loved by students for the dexterity in combining scope and accessibility. This latest volume, with its focus on community mental health, user movements criminal justice and the need for inter-agency working, alongside the more classical sociological critiques around social theories and social inequalities, demonstrates more than ever that sociological perspectives are crucial in the understanding and explanation of mental and emotional healthcare and practice, hence its audience extends across the related disciplines to everyone who is involved in this highly controversial and socially relevant arena." Gillian Bendelow, School of Law Politics and Sociology, University of Sussex, UK "From the classic bedrock studies to contemporary sociological perspectives on the current controversy over which scientific organizations will define diagnosis, Rogers and Pilgrim provide a comprehensive, readable and elegant overview of how social factors shape the onset and response to mental health and mental illness. Their sociological vision embraces historical, professional and socio-cultural context and processes as they shape the lives of those in the community and those who provide care; the organizations mandated to deliver services and those that have ended up becoming unsuitable substitutes; and the successful and unsuccessful efforts to improve the lives through science, challenge and law." Bernice Pescosolido, Distinguished Professor of Sociology, Indiana University, USA




The Summer House


Book Description

THE STUNNING NOVEL, PERFECT FOR A SUMMER HOLIDAY, FROM THE NUMBER ONE BESTSELLING AUTHOR A life-changing secret. An unforgettable summer. Arriving at the familiar old stone church nestled in the beautiful countryside of Hampshire, Antoinette prepares to say goodbye to her husband; the man she has loved for as long as she can remember. Little does she know, the arrival of the beautiful and mysterious Phaedra will make her question everything about the man she shared her life with. Phaedra loved George too, and couldn’t bear to stay away from his funeral. But Phaedra is hiding a deeply buried secret. One that will change the lives of Antoinette and her family forever, and one that she can no longer keep hidden . . . Bestselling author Santa Montefiore delivers a captivating novel about love, family and secrets that will stay with you long after you’ve finished reading. A beautiful summer read for fans of Lucinda Riley, Victoria Hislop and Joanna Trollope. ***PRAISE FOR SANTA MONTEFIORE*** ‘Nobody does epic romance like Santa Montefiore’ JOJO MOYES ‘An enchanting read overflowing with deliciously poignant moments’ DINAH JEFFERIES on Songs of Love and War ‘Santa Montefiore hits the spot for my like few other writers’ SARRA MANNING ‘One of our personal favourites’ THE TIMES on The Last Secret of the Deverills ‘Accomplished and poetic’ Daily Mail ‘Santa Montefiore is a marvel’ Sunday Express




Genetic Steroid Disorders


Book Description

Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It is designed to assist these specialists in the diagnosis and treatment of steroid disorders. This revision includes a new chapter on "Gonadotropins, Obesity and Bone" and new research on non-invasive prenatal diagnosis with cell-free DNA. Chapters are thoroughly updated covering steroid disorders, the genetic bases for the disorder and case presentations, This definitive reference belongs in every medical library! - Presents a comprehensive, translational look at all aspects of genetic steroid disorders in one reference work - Provides a common language for endocrinologists, geneticists, molecular pathologists, and genetic counselors to discuss and diagnose genetic steroid disorders Saves clinicians and researchers time in quickly accessing the very latest details on genetic tests and diagnoses as opposed to searching through thousands of journal articles - Highlights significant discoveries with clinical relevance, presenting insight into which medications to use based on the genetic makeup of a patient - Teaches the best strategies and most effective use of genetic information in the patient counseling setting




Thyroid Autoimmunity


Book Description

In 1956, three groups independently reported evidence that some thyroid disease appearing spontaneously in humans or experimentally induced in animals are related to autoimmune processes. The interval between these landmark discoveries and the present has witnessed a remarkable and continuing growth of both knowledge and concepts concerning the mechanisms of immune regulation, the pathogenesis of autoimmune thyroid diseases, and their clinical and laboratory manifestations. More importantly knowledge of thyroid autoimmunity has, in many respects, comprised the vanguard of an ever increasing appreciation and understanding of autoimmune diseases in general. On November 24-26 1986, an International Symposium on Thyroid Autoimmunity was held in Pisa. Its purpose was to commemorate the birth of thyroid autoimmunity as a scientific discipline, to summarize current knowledge and concepts in this area, and where possible, to anticipate areas of opportunity for the future - hence the theme of the Symposium, Memories and Perspectives. To open the meeting, the Magnifico Rettore (Chancellor) of the University of Pisa granted special Awards to Dr. Deborah Doniach, Dr. Ivan Roitt, and Dr. Noel R. Rose, who published the first fundamental studies in the field of thyroid autoimmunity, and to Dr. Duncan G. Adams, whose discovery of the long-acting thyroid stimulator (LATS) opened the door to our current understanding of the pathogenesis of Graves' disease. During the meeting thirty plenary lectures were presented.




Mechanisms of Insulin Action


Book Description

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.