A Guide to Numerical Modelling in Systems Biology


Book Description

This book is intended for students of computational systems biology with only a limited background in mathematics. Typical books on systems biology merely mention algorithmic approaches, but without offering a deeper understanding. On the other hand, mathematical books are typically unreadable for computational biologists. The authors of the present book have worked hard to fill this gap. The result is not a book on systems biology, but on computational methods in systems biology. This book originated from courses taught by the authors at Freie Universität Berlin. The guiding idea of the courses was to convey those mathematical insights that are indispensable for systems biology, teaching the necessary mathematical prerequisites by means of many illustrative examples and without any theorems. The three chapters cover the mathematical modelling of biochemical and physiological processes, numerical simulation of the dynamics of biological networks and identification of model parameters by means of comparisons with real data. Throughout the text, the strengths and weaknesses of numerical algorithms with respect to various systems biological issues are discussed. Web addresses for downloading the corresponding software are also included.




Geometric Modelling, Numerical Simulation, and Optimization:


Book Description

This edited volume addresses the importance of mathematics for industry and society by presenting highlights from contract research at the Department of Applied Mathematics at SINTEF, the largest independent research organization in Scandinavia. Examples range from computer-aided geometric design, via general purpose computing on graphics cards, to reservoir simulation for enhanced oil recovery. Contributions are written in a tutorial style.




Applied Groundwater Modeling


Book Description

This second edition is extensively revised throughout with expanded discussion of modeling fundamentals and coverage of advances in model calibration and uncertainty analysis that are revolutionizing the science of groundwater modeling. The text is intended for undergraduate and graduate level courses in applied groundwater modeling and as a comprehensive reference for environmental consultants and scientists/engineers in industry and governmental agencies. - Explains how to formulate a conceptual model of a groundwater system and translate it into a numerical model - Demonstrates how modeling concepts, including boundary conditions, are implemented in two groundwater flow codes-- MODFLOW (for finite differences) and FEFLOW (for finite elements) - Discusses particle tracking methods and codes for flowpath analysis and advective transport of contaminants - Summarizes parameter estimation and uncertainty analysis approaches using the code PEST to illustrate how concepts are implemented - Discusses modeling ethics and preparation of the modeling report - Includes Boxes that amplify and supplement topics covered in the text - Each chapter presents lists of common modeling errors and problem sets that illustrate concepts




Introduction to Numerical Geodynamic Modelling


Book Description

This user-friendly reference for students and researchers presents the basic mathematical theory, before introducing modelling of key geodynamic processes.




Modeling in Engineering Using Innovative Numerical Methods for Solids and Fluids


Book Description

The book examines innovative numerical methods for computational solid and fluid mechanics that can be used to model complex problems in engineering. It also presents innovative and promising simulation methods, including the fundamentals of these methods, as well as advanced topics and complex applications. Further, the book explores how numerical simulations can significantly reduce the number of time-consuming and expensive experiments required, and can support engineering decisions by providing data that would be very difficult, if not impossible, to obtain experimentally. It also includes chapters covering topics such as particle methods addressing particle-based materials and numerical methods that are based on discrete element formulations; fictitious domain methods; phase field models; computational fluid dynamics based on modern finite volume schemes; hybridizable discontinuous Galerkin methods; and non-intrusive coupling methods for structural models.




Advanced Numerical Simulation Methods


Book Description

This entertaining introduction to advanced numerical modeling aims to lead the reader on a journey towards theholy grail of numerical simulation, i.e. one without the requirement of mesh generation, that takes data directly from CAD programs. This hands-on book emphasizes implementation and examples of programming in a higher level language are given. Written for users of simulation software, so they can understand the benefits of this new technology and demand progress from a somewhat conservative industry. Written for software developers, so they can see that this is a technology with a big future and written for researchers, in the hope that it will attract more people to work in this field.




Innovative Numerical Modelling in Geomechanics


Book Description

Since the 1990s five books onApplications of Computational Mechanics in Geotechnical Engineering have been published. Innovative Numerical Modelling in Geomechanics is the 6th and final book in this series, and contains papers written by leading experts on computational mechanics. The book treats highly relevant topics in the field of geotechnic




Numerical Techniques for Global Atmospheric Models


Book Description

This book surveys recent developments in numerical techniques for global atmospheric models. It is based upon a collection of lectures prepared by leading experts in the field. The chapters reveal the multitude of steps that determine the global atmospheric model design. They encompass the choice of the equation set, computational grids on the sphere, horizontal and vertical discretizations, time integration methods, filtering and diffusion mechanisms, conservation properties, tracer transport, and considerations for designing models for massively parallel computers. A reader interested in applied numerical methods but also the many facets of atmospheric modeling should find this book of particular relevance.




Numerical Methods for Nonlinear Engineering Models


Book Description

There are many books on the use of numerical methods for solving engineering problems and for modeling of engineering artifacts. In addition there are many styles of such presentations ranging from books with a major emphasis on theory to books with an emphasis on applications. The purpose of this book is hopefully to present a somewhat different approach to the use of numerical methods for - gineering applications. Engineering models are in general nonlinear models where the response of some appropriate engineering variable depends in a nonlinear manner on the - plication of some independent parameter. It is certainly true that for many types of engineering models it is sufficient to approximate the real physical world by some linear model. However, when engineering environments are pushed to - treme conditions, nonlinear effects are always encountered. It is also such - treme conditions that are of major importance in determining the reliability or failure limits of engineering systems. Hence it is essential than engineers have a toolbox of modeling techniques that can be used to model nonlinear engineering systems. Such a set of basic numerical methods is the topic of this book. For each subject area treated, nonlinear models are incorporated into the discussion from the very beginning and linear models are simply treated as special cases of more general nonlinear models. This is a basic and fundamental difference in this book from most books on numerical methods.