Skeletal Growth and Development


Book Description

This important book enables physicians to take full advantage of recent scientific progress to develop new, more effective treatment options. Orthopaedic surgeons, cell and molecular biologists, and bioengineers define current clinical issues and knowledge.




Basic Science Methods for Clinical Researchers


Book Description

Basic Science Methods for Clinical Researchers addresses the specific challenges faced by clinicians without a conventional science background. The aim of the book is to introduce the reader to core experimental methods commonly used to answer questions in basic science research and to outline their relative strengths and limitations in generating conclusive data. This book will be a vital companion for clinicians undertaking laboratory-based science. It will support clinicians in the pursuit of their academic interests and in making an original contribution to their chosen field. In doing so, it will facilitate the development of tomorrow's clinician scientists and future leaders in discovery science. - Serves as a helpful guide for clinical researchers who lack a conventional science background - Organized around research themes pertaining to key biological molecules, from genes, to proteins, cells, and model organisms - Features protocols, techniques for troubleshooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data - Appendices provide resources for practical research methodology, including legal frameworks for using stem cells and animals in the laboratory, ethical considerations, and good laboratory practice (GLP)




The Eye


Book Description

The Eye: Basic Sciences in Practice provides highly accessible, concise coverage of all the essential basic science required by today's ophthalmologists and optometrists in training. It is also essential reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area. This new fourth edition has now been fully revised and updated in line with current curricula, key research developments and clinical best practice. It succinctly incorporates the massive strides being made by genetics and functional genomics based on the Human Genome Project, the new understanding of how the microbiome affects all aspects of immunology, the remarkable progress in imaging technology now applied to anatomy and neurophysiology, as well as exciting new molecular and other diagnostic methodologies now being used in microbiology and pathology. All this and more collectively brings a wealth of new knowledge to students and practitioners in the fields of ophthalmology and visual science. For the first time, this (print) edition also now comes with bonus access to the complete, fully searchable electronic text - including carefully selected additional information and new video content to further explain and expand on key concepts - making The Eye a more flexible, comprehensive and engaging learning package than ever before. The only all-embracing textbook of basic science suitable for trainee ophthalmologists, optometrists and vision scientists - other books concentrate on the individual areas such as anatomy. Attractive page design with clear, colour diagrams and text boxes make this a much more accessible book to learn from than many postgraduate textbooks. Presents in a readable form an account of all the basic sciences necessary for an understanding of the eye - anatomy, embryology, genetics, biochemistry, physiology, pharmacology, immunology, microbiology and infection and pathology. More on molecular pathology. Thorough updating of the sections on pathology, immunology, pharmacology and immunology. Revision of all other chapters. More colour illustrations Comes with complete electronic version




Basic Sciences for Dental Students


Book Description

The ‘all-in-one’ solution to mastering basic sciences in preclinical dentistry Basic Sciences for Dental Students is a cutting edge textbook specifically designed to support the needs of early years undergraduate dental students. Written by leaders in dental education and active oral and dental researchers involved with student assessment, the text explains the basic science that underpins the dental curriculum in undergraduate dental courses worldwide. Specifically related to dentistry and future clinical practice, chapters cover all of the introductory subjects that students need to know – biomolecules, cell biology, tissues of the body, cardiovascular, circulatory and pulmonary systems, the nervous system, immunology, oral microbiology, pathology, head and neck anatomy, tooth development, craniofacial development, saliva, and dental materials. Key features: Provides the basic science that underpins the early years of a dental curriculum Specifically tailored towards dentistry and future clinical practice Written by leaders in dental education and active oral and dental researchers Includes learning objectives and clinical relevance boxes throughout Self-assessment questions and downloadable figures are hosted on a companion website Basic Sciences for Dental Students is an indispensable resource for undergraduate dental students, especially those in the early years of their studies. It is also a useful revision tool for postgraduate MJDF and MFDS examinations and overseas candidates sitting their OREs.




Basic Sciences and Development


Book Description

First published in 1998. In the Third World, development-orientated research in the basic sciences have received a negligible share of available resources from domestic and foreign sources. This book addresses the growing concerns regarding the policies guiding support to development research in recipient countries.




Science and Technology and the Future Development of Societies


Book Description

In June 2006, seventeen scientists and educators selected by the National Academies, the Academy of Sciences of Iran, and the Académie des Sciences of France held a workshop at the estate of the Fondation des Treilles in Toutour, France, to discuss issues concerning the role of science in the development of modern societies. Science and Technology and the Future Development of Societies includes the presentations made at the workshop and summarizes the discussions that followed the presentations. Topics of the workshop included science and society issues, the role of science and engineering in development; obstacles and opportunities in the application of science and technology to development; scientific thinking of decision makers; management and utilization of scientific knowledge; and science, society, and education. This book also provides useful background for the further development of interactions of Western scientists and educators with Iranian specialists.




Positron Emission Tomography


Book Description

Essential for students, science and medical graduates who want to understand the basic science of Positron Emission Tomography (PET), this book describes the physics, chemistry, technology and overview of the clinical uses behind the science of PET and the imaging techniques it uses. In recent years, PET has moved from high-end research imaging tool used by the highly specialized to an essential component of clinical evaluation in the clinic, especially in cancer management. Previously being the realm of scientists, this book explains PET instrumentation, radiochemistry, PET data acquisition and image formation, integration of structural and functional images, radiation dosimetry and protection, and applications in dedicated areas such as drug development, oncology, and gene expression imaging. The technologist, the science, engineering or chemistry graduate seeking further detailed information about PET, or the medical advanced trainee wishing to gain insight into the basic science of PET will find this book invaluable. This book is primarily repackaged content from the Basic Science section of the 'big' Valk book on PET. It contains new, completely revised and unchanged chapters covering the "basic sciences" section of the main book - total 18 chapters: 2 new (chapters 1, 16) 8 completely revised (chapters 4, 5, 8, 13, 14, 15, 17, 18) 3 minor corrections (chapters 2, 6, 11) 5 unchanged (chapters 3, 7, 9, 10, 12)




Basic Principles of Drug Discovery and Development


Book Description

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, which requires a multidisciplinary team approach with input from medicinal chemists, biologists, pharmacologists, drug metabolism experts, toxicologists, clinicians, and a host of experts from numerous additional fields. Enabling technologies such as high throughput screening, structure-based drug design, molecular modeling, pharmaceutical profiling, and translational medicine are critical to the successful development of marketable therapeutics. Given the wide range of disciplines and techniques that are required for cutting edge drug discovery and development, a scientist must master their own fields as well as have a fundamental understanding of their collaborator's fields. This book bridges the knowledge gaps that invariably lead to communication issues in a new scientist's early career, providing a fundamental understanding of the various techniques and disciplines required for the multifaceted endeavor of drug research and development. It provides students, new industrial scientists, and academics with a basic understanding of the drug discovery and development process. The fully updated text provides an excellent overview of the process and includes chapters on important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles of in vivo pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. - Provides a clear explanation of how the pharmaceutical industry works, as well as the complete drug discovery and development process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual property - Includes a new chapter on the discovery and development of biologics (antibodies proteins, antibody/receptor complexes, antibody drug conjugates), a growing and important area of the pharmaceutical industry landscape - Features a new section on formulations, including a discussion of IV formulations suitable for human clinical trials, as well as the application of nanotechnology and the use of transdermal patch technology for drug delivery - Updated chapter with new case studies includes additional modern examples of drug discovery through high through-put screening, fragment-based drug design, and computational chemistry




A Framework for K-12 Science Education


Book Description

Science, engineering, and technology permeate nearly every facet of modern life and hold the key to solving many of humanity's most pressing current and future challenges. The United States' position in the global economy is declining, in part because U.S. workers lack fundamental knowledge in these fields. To address the critical issues of U.S. competitiveness and to better prepare the workforce, A Framework for K-12 Science Education proposes a new approach to K-12 science education that will capture students' interest and provide them with the necessary foundational knowledge in the field. A Framework for K-12 Science Education outlines a broad set of expectations for students in science and engineering in grades K-12. These expectations will inform the development of new standards for K-12 science education and, subsequently, revisions to curriculum, instruction, assessment, and professional development for educators. This book identifies three dimensions that convey the core ideas and practices around which science and engineering education in these grades should be built. These three dimensions are: crosscutting concepts that unify the study of science through their common application across science and engineering; scientific and engineering practices; and disciplinary core ideas in the physical sciences, life sciences, and earth and space sciences and for engineering, technology, and the applications of science. The overarching goal is for all high school graduates to have sufficient knowledge of science and engineering to engage in public discussions on science-related issues, be careful consumers of scientific and technical information, and enter the careers of their choice. A Framework for K-12 Science Education is the first step in a process that can inform state-level decisions and achieve a research-grounded basis for improving science instruction and learning across the country. The book will guide standards developers, teachers, curriculum designers, assessment developers, state and district science administrators, and educators who teach science in informal environments.




Basic Sciences for Core Medical Training and the MRCP


Book Description

Providing a clear explanation of the relevant medical science behind the individual medical specialties, Basic Science for Core Medical Training and the MRCP, is an indispensable part of a candidate's MRCP preparation. Directly linked to the Royal College exam, the book follows the same systems-based approach as the syllabus for accurate and effective revision. With full coverage of basic science for the medical specialities, the book features material on genetics, cellular, molecular and membrane biology, and biochemistry. Content is presented in an illustrated and easy-to-read format, ensuring that the basic science for each medical specialty is more approachable and accessible. A focus on how the basic sciences aid understanding of clinical practice is reinforced through key tables of differential diagnoses and pharmacology. Ten multiple choice questions at the end of each chapter consolidate learning and enable candidates to test their knowledge. The book also covers common examination errors and areas of misunderstanding to aid learning and help candidates avoid common pitfalls.




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